33/#939 Trends in phase 3 clinical trials in ovarian cancer from 2001–2021

Abstract

germ cell cancers in Native Chinese is nearly 2-fold higher compared to US Asians 0.66 vs. 0.36 per 100,000. In Native Chinese, the incidence is increasing with an average annual percent change (AAPC) at 1.4% (p=0.006) whereas in US Asians there is no change (AAPC=-0.10%, p=0.89). To further evaluate the trends in Native Chinese, we found that the incidence (in 2018) of immature teratomas was nearly 3fold higher compared to dysgerminoma and yolk-sac tumors (0.32 vs. 0.11 vs. 0.10). Moreover, immature teratomas are increasing at 3.46% per year (p<0.001) whereas the dysgerminoma and yolk-sac tumors have remained stable. An intersectional analysis showed Native Chinese at age 10-14 with immature teratoma had the highest annual increase (7.56%, p=0.016). Conclusions Incidences of germ cell tumors have increased in Native Chinese but remained stable in US Asians. The higher incidence and increasing rates of the immature teratoma subtype warrants further studies on potential genetic and environmental factors.