Global mean diffusivity: A radiomarker discriminating good outcome long term after traumatic brain injury

Debarle, C.; Perlbarg, Vincent; Jacquens, Alice; Pélégrini‐Issac, Mélanie; M, Bisch; Prigent, Arnaud; Lesimple, Blandine; Caron, Elsa; Lefort, Muriel; Bayen, É.; Galanaud, Damien; Pradat‐Diehl, Pascale; Puybasset, Louis; Degos, Vincent

doi:10.1016/j.rehab.2020.08.002

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Annals of Physical and Rehabilitation Medicine

2021

DOI: 10.1016/j.rehab.2020.08.002

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Global mean diffusivity: A radiomarker discriminating good outcome long term after traumatic brain injury

C. Debarle¹,

Vincent Perlbarg²,

Alice Jacquens³

et al.

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Cited by 3 publications

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“…Although called mTBI, it could cause various neurological disorders, among which cognitive impairment is a most common one 3,4 . Previous neuroimaging studies have revealed brain structural and functional network changes underlying cognitive impairment after mTBI, especially global white matter damage 5–8 . However, brain waste clearance deficiency may also play an important role in cognitive impairment after mTBI.…”

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confidence: 99%

Associations of MRI‐Derived Glymphatic System Impairment With Global White Matter Damage and Cognitive Impairment in Mild Traumatic Brain Injury: A DTI‐ALPS Study

Yang

Sun

et al. 2023

Magnetic Resonance Imaging

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BackgroundAssessing the glymphatic function using diffusion tensor image analysis along the perivascular space (DTI‐ALPS) may be helpful for mild traumatic brain injury (mTBI) management.PurposeTo assess glymphatic function using DTI‐ALPS and its associations with global white matter damage and cognitive impairment in mTBI.Study TypeProspective.PopulationThirty‐four controls (44.1% female, mean age 49.2 years) and 58 mTBI subjects (43.1% female, mean age 48.7 years), including uncomplicated mTBI (N = 32) and complicated mTBI (N = 26).Field Strength/Sequence3‐T, single‐shot echo‐planar imaging sequence.AssessmentMagnetic resonance imaging (MRI) was done within 1 month since injury. DTI‐ALPS was performed to assess glymphatic function, and peak width of skeletonized mean diffusivity (PSMD) was used to assess global white matter damage. Cognitive tests included Auditory Verbal Learning Test and Digit Span Test (forward and backward).Statistical TestsNeuroimaging findings comparisons were done between mTBI and control groups. Partial correlation and multivariable linear regression assessed the associations between DTI‐ALPS, PSMD, and cognitive impairment. Mediation effects of PSMD on the relationship between DTI‐ALPS and cognitive impairment were explored. P‐value <0.05 was considered statistically significant, except for cognitive correlational analyses with a Bonferroni‐corrected P‐value set at 0.05/3 ≈ 0.017.ResultsmTBI showed lower DTI‐ALPS and higher PSMD, especially in complicated mTBI. DTI‐ALPS was significantly correlated with verbal memory (r = 0.566), attention abilities (r = 0.792), executive function (r = 0.618), and PSMD (r = −0.533). DTI‐ALPS was associated with verbal memory (β = 8.77, 95% confidence interval [CI] 5.00, 12.54), attention abilities (β = 5.67, 95% CI 4.56, 6.97), executive function (β = 2.34, 95% CI 1.49, 3.20), and PSMD (β = −0.79, 95% CI −1.15, −0.43). PSMD mediated 46.29%, 20.46%, and 24.36% of the effects for the relationship between DTI‐ALPS and verbal memory, attention abilities, and executive function.Data ConclusionGlymphatic function may be impaired in mTBI reflected by DTI‐ALPS. Glymphatic dysfunction may cause cognitive impairment related to global white matter damage after mTBI.Level of Evidence2Technical EfficacyStage 2

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Associations of MRI‐Derived Glymphatic System Impairment With Global White Matter Damage and Cognitive Impairment in Mild Traumatic Brain Injury: A DTI‐ALPS Study

Yang

Sun

et al. 2023

Magnetic Resonance Imaging

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Toward a coherent structuration of disorders of consciousness expertise at a country scale: A proposal for France

Naccache

Luauté²,

Silva³

et al. 2022

Revue Neurologique

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MRI volumetry and diffusion tensor imaging for diagnosis and follow-up of late post-traumatic injuries

Jacquens,

Delmotte,

Gourbeix

et al. 2024

Annals of Physical and Rehabilitation Medicine

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Global mean diffusivity: A radiomarker discriminating good outcome long term after traumatic brain injury

Cited by 3 publications

References 39 publications

Associations of MRI‐Derived Glymphatic System Impairment With Global White Matter Damage and Cognitive Impairment in Mild Traumatic Brain Injury: A DTI‐ALPS Study

Associations of MRI‐Derived Glymphatic System Impairment With Global White Matter Damage and Cognitive Impairment in Mild Traumatic Brain Injury: A DTI‐ALPS Study

Toward a coherent structuration of disorders of consciousness expertise at a country scale: A proposal for France

MRI volumetry and diffusion tensor imaging for diagnosis and follow-up of late post-traumatic injuries

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