Maternal antenatal stress and mental and behavioral disorders in their children

Tuovinen, Soile; Lahti‐Pulkkinen, Marius; Girchenko, Polina; Heinonen, Kati; Lahti, Jari; Reynolds, Rebecca M.; Hämäläinen, Esa; Villa, Pia; Kajantie, Eero; Laivuori, Hannele; Räikkönen, Katri

doi:10.1016/j.jad.2020.09.063

Cited by 33 publications

(15 citation statements)

References 47 publications

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“…However, also other mechanisms than maternal nutrition may have contributed to our findings. Convincing evidence shows that maternal obesity is associated with increased depressive and symptoms during pregnancy 40 and that maternal depressive and anxiety symptoms during pregnancy are associated with increased psychopathology risk in the offspring 41 , 42 . Increased psychological distress during pregnancy in obese women, contributing to offspring psychopathology risk via prenatal programming or genetic or shared environmental pathways 43 may thus explain the associations between maternal BMI and offspring mental disorders.…”

Section: Discussionmentioning

confidence: 99%

Maternal body mass index in pregnancy and mental disorders in adult offspring: a record linkage study in Aberdeen, Scotland

Lahti‐Pulkkinen

Räikkönen

Bhattacharya

et al. 2021

Sci Rep

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Maternal obesity in pregnancy predicts offspring psychopathology risk in childhood but it remains unclear whether maternal obesity or underweight associate with adult offspring mental disorders. We examined longitudinally whether maternal body mass index (BMI) in pregnancy predicted mental disorders in her offspring and whether the associations differed by offspring birth year among 68,571 mother–child dyads of Aberdeen Maternity and Neonatal Databank, Scotland. The offspring were born 1950–1999. Maternal BMI was measured at a mean 15.7 gestational weeks and classified into underweight, normal weight, overweight, moderate obesity and severe obesity. Mental disorders were identified from nationwide registers carrying diagnoses of all hospitalizations and deaths in Scotland in 1996–2017. We found that maternal BMI in pregnancy was associated with offspring mental disorders in a time-dependent manner: In offspring born 1950–1974, maternal underweight predicted an increased hazard of mental disorders [Hazard Ratio (HR) = 1.74; 95% Confidence Interval (CI) = 1.01–3.00)]. In offspring born 1975–1999, maternal severe obesity predicted increased hazards of any mental (HR 1.60; 95% CI 1.08–2.38) substance use (HR 1.91; 95% CI 1.03–3.57) and schizophrenia spectrum (HR 2.80; 95% CI 1.40–5.63) disorders. Our findings of time-specific associations between maternal prenatal BMI and adult offspring mental disorders may carry important public health implications by underlining possible lifelong effects of maternal BMI on offspring psychopathology.

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Section: Discussionmentioning

confidence: 99%

Maternal body mass index in pregnancy and mental disorders in adult offspring: a record linkage study in Aberdeen, Scotland

Lahti‐Pulkkinen

Räikkönen

Bhattacharya

et al. 2021

Sci Rep

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“…Apart from the implicated association with preterm birth, maternal PPD has been also linked with the child’s higher risk for mental and behavioral disorders 14 , 15 , which suggests that PPD may be on a pathway between preterm birth and mental and behavioral disorders in children. One previous study has reported that maternal major depressive disorder (MDD) diagnosis between childbirth and child’s assessment in early childhood mediated the association between lower gestational age and child’s risk for anxiety disorders 16 .…”

Section: Introductionmentioning

confidence: 99%

Maternal postpartum depressive symptoms partially mediate the association between preterm birth and mental and behavioral disorders in children

Girchenko

Robinson

Rantalainen

et al. 2022

Sci Rep

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Preterm birth has been linked with postpartum depressive (PPD) disorders and high symptom levels, but evidence remains conflicting and limited in quality. It remains unclear whether PPD symptoms of mothers with preterm babies were already elevated before childbirth, and whether PPD symptoms mediate/aggravate the effect of preterm birth on child mental disorders. We examined whether preterm birth associated with maternal PPD symptoms, depressive symptoms trajectories from antenatal to postpartum stage, and whether PPD symptoms mediated/aggravated associations between preterm birth and child mental disorders. Mothers of preterm (n = 125) and term-born (n = 3033) children of the Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction study reported depressive symptoms four times within 8 weeks before and twice within 12 months after childbirth. Child mental and behavioral disorder diagnoses until age 8.4–12.8 years came from medical register. Preterm birth associated with higher PPD symptoms (mean difference = 0.19 SD, 95% CI 0.01, 0.37, p = 0.04), and higher odds (odds ratio = 2.23, 95% CI 1.22, 4.09, p = 0.009) of the mother to belong to a group that had consistently high depressive symptoms levels trajectory from antenatal to postpartum stage. PPD symptoms partially mediated and aggravated the association between preterm birth and child mental disorders. Preterm birth, maternal PPD symptoms and child mental disorders are associated, calling for timely prevention interventions.

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“…In the few studies reporting longitudinal depressive symptom trajectories across pregnancy, samples have been of heterogeneous BMI and include post-partum time points 11 , 12 or suggest the potential role of but do not include biological markers. 13 , 14 There is a need for a comprehensive description of the associations between maternal depression, obesity and fetal exposures in which depression is assessed longitudinally throughout pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal phenotyping of maternal antenatal depression in obese pregnant women supports multiple-hit hypothesis for fetal brain development, a secondary analysis of the UPBEAT study

et al. 2022

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Maternal antenatal stress and mental and behavioral disorders in their children

Cited by 33 publications

References 47 publications

Maternal body mass index in pregnancy and mental disorders in adult offspring: a record linkage study in Aberdeen, Scotland

Maternal body mass index in pregnancy and mental disorders in adult offspring: a record linkage study in Aberdeen, Scotland

Maternal postpartum depressive symptoms partially mediate the association between preterm birth and mental and behavioral disorders in children

Longitudinal phenotyping of maternal antenatal depression in obese pregnant women supports multiple-hit hypothesis for fetal brain development, a secondary analysis of the UPBEAT study

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