Sarcopenia is a useful risk stratification tool to prognosticate splenic abscess patients in the emergency department

Hung, Shang-Kai; Kou, Hao-Wei; Hsu, Kuang-Hung; Wu, Chiao‐En; Lee, Chao‐Wei; Goh, Zhong Ning Leonard; Seak, Chen-Ken; Seak, Joanna Chen-Yeen; Liu, Ya-Tung; Seak, Chen-June; investigators, Spot

doi:10.1016/j.jfma.2020.08.039

Cited by 7 publications

(7 citation statements)

References 30 publications

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“…Previous studies have linked the presence of sarcopenia to increased susceptibility to infection, higher risk of complications such as postoperative infection and mortality in patients undergoing surgery ( Kaido et al, 2013 ; Tosteson et al, 2007 ), and poor prognosis in patients with sepsis or respiratory failure ( Hung et al, 2021 ). In a study of 149 elderly ICU patients with injuries, sarcopenia was an independent predictor of mortality ( Moisey et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

“…Body composition, including muscle and fat mass, has been increasingly linked to the clinical course, treatment response, and prognosis of various diseases ( Grillot et al, 2020 ; Hung et al, 2021 ; Kang et al, 2019 ; Kang et al, 2018 ). Sarcopenia, which is characterized by a loss of skeletal muscle mass and strength due to various reasons, was first proposed by Rosenberg (1989) and Chen et al.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, sarcopenia is thought to be closely related to infection because it may lead to an immunosuppressive state in which the body’s ability to fight against infection is weakened ( Kaido et al, 2013 ; Schaible & Kaufmann, 2007 ). The results of a large-scale multi-center study on patients with splenic abscess suggest a strong association between sarcopenia and poor prognosis, specifically hospital mortality, in such patients ( Hung et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess

Liu,

Hao

et al. 2023

PeerJ

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Background Low muscle mass/sarcopenia has been associated with poor prognosis in many diseases, but its clinical significance in pyogenic liver abscess (PLA) remains unclear. The purpose of this study is to investigate the relationship between muscle mass and prognosis of patients with PLA. Methods A total of 154 adult patients with PLA hospitalized at Tongji Hospital (Wuhan, Hubei, China) between October 2011 and June 2021 were included in this retrospective analysis. Muscle-fat related indicators were measured by computed tomography (CT) images at the third lumbar vertebra (L3) level. The data of patients between the sarcopenia group and non-sarcopenia group were compared. Multivariate logistic regression and receiver operating characteristic (ROC) curve analyses were performed. Results The skeletal muscle index (SMI) was independently associated with adverse outcomes (95% CI [0.649–0.954], P = 0.015) of PLA in multivariate logistic regression analysis. This conclusion held true in sex-specific subgroup analysis. ROC analysis indicated that SMI may predict adverse outcomes in both male (area under the ROC curve [AUC], 0.718; cut-off, 52.59; P < 0.001) and female (AUC, 0.714; cut-off, 38.39; P = 0.017) patient populations. Conclusions Sarcopenia serves as an independent risk factor for poor prognosis in PLA and patients with sarcopenia may be more prone to adverse outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess

Liu,

Hao

et al. 2023

PeerJ

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“…Большинство авторов считают пороговым значением SMI, ниже которого состояние мышечной ткани расценивается как саркопения, 52,4 см 2 /м 2 для мужчин и 38,5 см 2 /м 2 для женщин [1,[14][15][16]. Ряд исследователей использует в качестве пороговых значений SMI менее 55,4 см 2 /м 2 для мужчин и менее 38,9 см 2 /м 2 для женщин [17]. Проведенный в 2019 г. метаанализ показал, что наиболее распространенные ключевые значения SMI для определения мышечной массы при обследовании на КТ составляют от 52 до 55 см 2 /м 2 для мужчин и от 39 до 41 см 2 /м 2 для женщин [2] (таблица).…”

Section: кт -инструмент саркометрииunclassified

Role of computed tomography in sarcopenia detection

Sheberova,

Silanteva,

Agababian

et al. 2023

Sib. onkol. ž.

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The study aimed to summarize the available data on the role of computed tomography in sarcopenia detection in cancer patients. Material and Methods. A literature search was conducted in the Medline, Scopus, Pubmed, and Elibrary systems. More than 100 articles published in 2008-2022 were analyzed. We included 45 articles in this review. Results. According to the European Consensus, sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength due to age-related, neurohumoral changes, malnutrition or muscle catabolism. It is difficult to overestimate the importance of sarcopenia, since this syndrome is one of the five main risk factors for morbidity and mortality in people over 65 years of age. Sarcopenia is mainly observed in inflammatory diseases, malignancy or organ failure. According to most researchers, CT is considered the gold standard method to assess muscle mass and quality. It is a reliable method for quantitative analysis, which was shown in a study based on the comparison of quantitative assessment of various muscle groups based on CT with muscle volume measured on cadaveric tissues. The purpose of this literature review was to highlight the importance of computed tomography for the detection of sarcopenia in clinical practice. Based on the results of the literature analysis, sarcopenia is still a challenge for modern oncology. Sarcopenia negatively affects the prognosis of the disease and quality of life of cancer patients. Sarcopenia may develop due to metabolic changes caused by cancer treatment, as a result of which the degradation of muscle protein begins to prevail over its synthesis. Conclusion. Given the high prevalence and prognostic significance of sarcopenia in oncology, the need for its early diagnosis and active treatment becomes obvious. The use of routine CT examinations for the diagnosis of sarcopenia will allow us to search for possible causes and optimize treatment, determine the likelihood of risks and determine the treatment strategy at an early stage, when therapy can be most effective.

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“…This study is part of a series by the Stratification to Prevent Overcrowding Taskforce (SPOT) investigators, a research group dedicated to maximising clinical outcomes right from the ED via rapid and accurate identification of patients requiring urgent intervention, with the secondary objective of alleviating ED overcrowding. We have to date studied several risk stratification tools in intra-abdominal infections [ 31 , 32 , 33 , 34 , 35 , 36 ], snakebites [ 37 ], and now advanced cancer [ 18 ], amongst others [ 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Shock Index Is a Validated Prediction Tool for the Short-Term Survival of Advanced Cancer Patients Presenting to the Emergency Department

Goh

Chen

Cheng

et al. 2022

JPM

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Advanced cancer patients who are not expected to survive past the short term can benefit from early initiation of palliative care in the emergency department (ED). This discussion, however, requires accurate prognostication of their short-term survival. We previously found in our retrospective study that shock index (SI) is an ideal risk stratification tool in predicting the 60-day mortality risk of advanced cancer patients presenting to the ED. This study is a follow-up prospective validation study conducted from January 2019 to April 2021. A total of 410 advanced cancer patients who presented to the ED of a medical centre and could be followed-up feasibly were recruited. Univariate and multivariable logistic regression analyses were performed with receiver operator calibrating (ROC) curve analysis. Non-survivors had significantly lower body temperatures, higher pulse rates, higher respiratory rates, lower blood pressures, and higher SI. Each 0.1 increment of SI increased the odds of 60-day mortality by 1.591. Area under ROC curve was 0.7819. At optimal cut-off of 0.94, SI had 66.10% accuracy. These results were similar to our previous study, thus validating the use of SI in predicting the 60-day mortality of advanced cancer patients presenting to the ED. Identified patients may be offered palliative care.

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Sarcopenia is a useful risk stratification tool to prognosticate splenic abscess patients in the emergency department

Cited by 7 publications

References 30 publications

Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess

Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess

Role of computed tomography in sarcopenia detection

Shock Index Is a Validated Prediction Tool for the Short-Term Survival of Advanced Cancer Patients Presenting to the Emergency Department

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