Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2

Agrón, Elvira; Mares, Julie A.; Clemons, Traci E; Swaroop, Anand; Chew, Emily Y.; Keenan, Tiarnán D L; Areds,

doi:10.1016/j.ophtha.2020.08.018

Cited by 92 publications

(98 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intervention studies with nutritional supplements containing L and Z have shown a decreased risk of progression to severe stages in nonadvanced AMD. 17,[74][75][76] Other studies have shown that supplementation with L, Z, and MZ enhances visual function. 18,21,[77][78][79][80][81][82] In addition, MP has been positively correlated to brain carotenoid levels 83,84 and cognitive function.…”

Section: Discussionmentioning

confidence: 99%

Environmental and Nutritional Determinants of Macular Pigment in a Mexican Population

Green

Moran

Stringham

et al. 2021

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

The carotenoids lutein (L), zeaxanthin (Z), and meso-zeaxanthin deposit at the macula as macular pigment (MP) and provide visual benefits and protection against macular diseases. The present study investigated MP, its nutritional and environmental determinants, and its constituent carotenoids in serum from a Mexican sample, in healthy participants and with metabolic diseases. Additionally, we compared these variables with an Irish sample.METHODS. MP was measured in 215 subjects from a rural community in Mexico with dualwavelength autofluorescence imaging reported as MP optical volume (MPOV). Dietary intake and serum concentrations of L and Z were evaluated. RESULTS.The mean MPOV was 8429 (95% confidence interval, 8060-8797); range. 1171-15,976. The mean L and Z serum concentrations were 0.25 ± 0.15 μmol/L and 0.09 ± 0.04 μmol/L, respectively. The MPOV was positively correlated with L and Z serum concentrations (r = 0.347; P < 0.001 and r = 0.311; P < 0.001, respectively), but not with L + Z dietary estimates. Subjects with daily sunlight exposure of more than 50% were found to have significantly higher MPOV than those with less than 50% (P = 0.005). MPOV and serum concentrations of L and Z were significantly higher in the Mexican sample compared with the Irish sample, but this difference was not reflected in dietary analysis. CONCLUSIONS.These new data from a Mexican sample provide evidence of the multifactorial interactions and environmental determinants of MP such as sunlight exposure and dietary patterns. These findings will be essential for future studies in Mexico for eye health, visual function, and ocular pathology.

show abstract

Section: Discussionmentioning

confidence: 99%

Environmental and Nutritional Determinants of Macular Pigment in a Mexican Population

Green

Moran

Stringham

et al. 2021

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Multiple clinical studies have demonstrated that diet plays a critical role in retinal health and contributes to diseases including age-related macular degeneration, diabetic retinopathy, and primary open angle glaucoma [42][43][44]. For example, recently published data from the AREDS study group reported that higher intake of saturated fatty acids, monounsaturated fatty acids, and oleic acid were associated with significant increased risk of progression to late AMD [45]. Supporting this, our team has previously published data showing that high-fat diet increased lesion size, vascular leakage, and sub-RPE deposits of laser-induced choroidal neovascularization in both wild-type and apolipoprotein Edeficient mice [15].…”

Section: Discussionmentioning

confidence: 99%

High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota

Dao

Xie

Nadeem

et al. 2021

Cells

View full text Add to dashboard Cite

The relationship between retinal disease, diet, and the gut microbiome has shown increasing importance over recent years. In particular, high-fat diets (HFDs) are associated with development and progression of several retinal diseases, including age-related macular degeneration (AMD) and diabetic retinopathy. However, the complex, overlapping interactions between diet, gut microbiome, and retinal homeostasis are poorly understood. Using high-throughput RNA-sequencing (RNA-seq) of whole retinas, we compare the retinal transcriptome from germ-free (GF) mice on a regular diet (ND) and HFD to investigate transcriptomic changes without influence of gut microbiome. After correction of raw data, 53 differentially expressed genes (DEGs) were identified, of which 19 were upregulated and 34 were downregulated in GF-HFD mice. Key genes involved in retinal inflammation, angiogenesis, and RPE function were identified. Enrichment analysis revealed that the top 3 biological processes affected were regulation of blood vessel diameter, inflammatory response, and negative regulation of endopeptidase. Molecular functions altered include endopeptidase inhibitor activity, protease binding, and cysteine-type endopeptidase inhibitor activity. Human and mouse pathway analysis revealed that the complement and coagulation cascades are significantly affected by HFD. This study demonstrates novel data that diet can directly modulate the retinal transcriptome independently of the gut microbiome.

show abstract

“…However, there is a lack of consensus among ophthalmologists and researchers on the interest of nutritional supplements containing antioxidant vitamins, carotenoids, trace elements and/or ω3 PUFAs in ophthalmology. Dry eye disease [14][15][16], myopia complications and progression [72], cataracts [32,73], or sightthreatening diseases such as glaucoma, DR, and AMD [16][17][18][19][20][21]32,[74][75][76][77][78][79], have been important targets of antioxidants and ω3 PUFAs. DHA is an essential structural constituent of cell membranes.…”

Section: Discussionmentioning

confidence: 99%

Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory Effects of DHA-Triglyceride. A Pilot Study

et al. 2021

View full text Add to dashboard Cite

The purpose of this study was to identify circulating biomarkers of recurrent non-infectious anterior uveitis (NIAU), and to address the anti-inflammatory effects of triglyceride containing docosahexaenoic acid (DHA-TG). A prospective multicenter study was conducted in 72 participants distributed into: patients diagnosed with recurrent NIAU in the quiescence stage (uveitis group (UG); n = 36) and healthy controls (control group (CG); n = 36). Each group was randomly assigned to the oral supplementation of one pill/day (+) containing DHA-TG (n = 18) or no-pill condition (−) (n = 17) for three consecutive months. Data from demographics, risk factors, comorbidities, eye complications and therapy were recorded. Blood was collected and processed to determine pro-inflammatory biomarkers by bead-base multiplex assay. Statistical processing with multivariate statistical analysis was performed. The mean age was 50, 12 (10, 31) years. The distribution by gender was 45% males and 55% females. The mean number of uveitis episodes was 5 (2). Higher plasma expression of interleukin (IL)-6 was detected in the UG versus the CG (p = 5 × 10−5). Likewise, significantly higher plasma levels were seen for IL-1β, IL-2, INFγ (p = 10−4), and TNFα (p = 2 × 10−4) in the UG versus the CG. Significantly lower values of the above molecules were found in the +DHA-TG than in the -DHA-TG subgroups, after 3 months of follow-up, TNFα (p = 10−7) and IL-6 (p = 3 × 10−6) being those that most significantly changed. Signatures of circulating inflammatory mediators were obtained in the quiescent stage of recurrent NIAU patients. This 3-month follow-up strongly reinforces that a regular oral administration of DHA-TG reduces the inflammatory load and may potentially supply a prophylaxis-adjunctive mediator for patients at risk of uveitis vision loss.

show abstract

Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2

Cited by 92 publications

References 73 publications

Environmental and Nutritional Determinants of Macular Pigment in a Mexican Population

Environmental and Nutritional Determinants of Macular Pigment in a Mexican Population

High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota

Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory Effects of DHA-Triglyceride. A Pilot Study

Contact Info

Product

Resources

About