“…In seven studies, anxiety was induced by the administration of a drug or toxin: these included lipopolysaccharide (LPS) (n = 2), streptozotocin (n = 2), corticosterone, kainate and arsenic (n = 1 each) [45,48,50,51,[54][55][56]. In two studies, anxiety was induced by subjecting animals to acute restraint [49,53]. In the remaining seven studies, no method of symptom provocation was used; instead, anxiety-like behaviours were compared across treated and control animals during the performance of specific experimental tasks, such as the open-field test, the elevated plus maze test, the light-dark box test, and the marble burying test [42-44, 46, 47, 53, 57].…”