Effect of Photobiomodulation (Diode 810 nm) on Long-Standing Neurosensory Alterations of the Inferior Alveolar Nerve: A Case Series Study

Elafifi, Haitham Abdelkarim; Carrero, Montserrat Acevedo; Parada-Avendaño, Isabel; España-Tost, Antonio Jesús; Arnabat-Domínguez, Josep

doi:10.1089/photob.2019.4780

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…PRISMA guidelines screening ( Supplementary Figure S1 ) resulted in 16 articles ( Table 2 and Table 3 ) [ 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ] suitable for the review, covering a total of 459 patients. Two were case reports, one was a retrospective study of clinical cases: one was a prospective study, six were case series studies and six were RCT (five double-blind and one triple-blind).…”

Section: Results Of Articles Screeningmentioning

confidence: 99%

Mitochondrial Bioenergetic, Photobiomodulation and Trigeminal Branches Nerve Damage, What’s the Connection? A Review

Ravera

Colombo

Pasquale

et al. 2021

IJMS

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Background: Injury of the trigeminal nerve in oral and maxillofacial surgery can occur. Schwann cell mitochondria are regulators in the development, maintenance and regeneration of peripheral nerve axons. Evidence shows that after the nerve injury, mitochondrial bioenergetic dysfunction occurs and is associated with pain, neuropathy and nerve regeneration deficit. A challenge for research is to individuate new therapies able to normalise mitochondrial and energetic metabolism to aid nerve recovery after damage. Photobiomodulation therapy can be an interesting candidate, because it is a technique involving cell manipulation through the photonic energy of a non-ionising light source (visible and NIR light), which produces a nonthermal therapeutic effect on the stressed tissue. Methods: The review was based on the following questions: (1) Can photo-biomodulation by red and NIR light affect mitochondrial bioenergetics? (2) Can photobiomodulation support damage to the trigeminal nerve branches? (preclinical and clinical studies), and, if yes, (3) What is the best photobiomodulatory therapy for the recovery of the trigeminal nerve branches? The papers were searched using the PubMed, Scopus and Cochrane databases. This review followed the ARRIVE-2.0, PRISMA and Cochrane RoB-2 guidelines. Results and conclusions: The reliability of photobiomodulatory event strongly bases on biological and physical-chemical evidence. Its principal player is the mitochondrion, whether its cytochromes are directly involved as a photoacceptor or indirectly through a vibrational and energetic variation of bound water: water as the photoacceptor. The 808-nm and 100 J/cm2 (0.07 W; 2.5 W/cm2; pulsed 50 Hz; 27 J per point; 80 s) on rats and 800-nm and 0.2 W/cm2 (0.2 W; 12 J/cm2; 12 J per point; 60 s, CW) on humans resulted as trustworthy therapies, which could be supported by extensive studies.

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Section: Results Of Articles Screeningmentioning

confidence: 99%

Mitochondrial Bioenergetic, Photobiomodulation and Trigeminal Branches Nerve Damage, What’s the Connection? A Review

Ravera

Colombo

Pasquale

et al. 2021

IJMS

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“…As the medical community strives to unravel the potential of photobiomodulation, questions abound regarding the outcomes that it yields in terms of the recovery of nervous function. Preliminary findings hint at the tantalizing prospect of accelerated nerve regeneration, potentially offering a new ray of hope for patients grappling with nerve injuries in the oral district [20][21][22]. By examining the documented results, insights emerge into the extent of neural recovery, improvements in sensory and motor functions, and the overall quality of life enhancements experienced by individuals subjected to this innovative treatment paradigm.…”

Section: Discussionmentioning

confidence: 99%

“…By examining the documented results, insights emerge into the extent of neural recovery, improvements in sensory and motor functions, and the overall quality of life enhancements experienced by individuals subjected to this innovative treatment paradigm. As research continues to illuminate the intricate mechanisms underlying photobiomodulation, a clearer picture emerges of its transformative potential in revitalizing nerve function and ushering in a new era of oral nerve injury rehabilitation [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Nerve Injury and Photobiomodulation, a Promising Opportunity: A Scoping Review on Laser Assisted Protocols for Lesions in the Oral Region

et al. 2023

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The currently available therapeutic options for restoring function and sensitivity in long-term nervous injuries pose challenges. Microsurgery interventions for direct nerve repair often lead to serious complications and limited success. Non-surgical methods, although somewhat effective, have limited benefits. These methods involve drug administration, such as with analgesics or corticosteroids. Photobiomodulation therapy (PBMT) has emerged as a promising approach based on clinical and laboratory studies. PBMT stimulates the migration and proliferation of neuronal fiber cellular aggregates, as reported in the literature. Experimental studies on animal models with peripheral nerve compression injuries have shown that PBMT can enhance the functionality of damaged nerves, preserving their activity and preventing scar tissue formation. The mechanism of action depends on the wavelength, which can positively or negatively affect photo acceptor resonances, influencing their conformation and activities. These findings suggest that photobiomodulation may accelerate and improve nerve regeneration. This review explores various methodologies used in photobiomodulation for regenerating nerve sensitivity after surgical trauma involving nerve structures, in the oral and peri-oral region. Research was conducted to evaluate which laser-assisted therapeutic protocols are used to improve the recovery of nervous sensitivity, using the JBI methodology for scoping reviews and following the PRISMA methodology.

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“…In the included studies, the etiologies of IAN damage were mostly sagittal split ramus osteotomy, only two studies for wisdom tooth extraction and two for mandibular fractures. Lesions due to impacted third molars extraction were mostly excluded because they were not RCTs or could not isolated from data mixed with lingual injuries [16,17,[40][41][42][43]. In addition, Qi W et al's article was the only one that used medicine therapy as a control (mecobalamin) instead of placebo.…”

Section: Plos Onementioning

confidence: 99%

The effectiveness of photobiomodulation therapy on inferior alveolar nerve injury: A systematic review and META-analysis

Yang

Chen

et al. 2023

PLoS ONE

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Objective The aim of this META-analysis was to evaluate the efficacy of photobiomodulation (PBM) therapy in the treatment of inferior alveolar nerve (IAN) injury due to orthognathic surgeries, extraction of impacted third molars and mandibular fractures. Methods and materials A electric search was conducted by a combination of manual search and four electric databases including Pubmed, Embase, Cochrane library and Web of Science, with no limitation on language and publication date. Gray literature was searched in ClinicalTrials.gov and googlescholar. All retrieved articles were imported into ENDNOTE software (version X9) and screened by two independent reviewers. All analysis was performed using the REVMAN software (version 5.3) Results Finally, 15 randomized controlled trials met the inclusion criteria for qualitative analysis and 14 for META-analysis from 219 articles. The results showed that PBM therapy had no effect on nerve injury in a short period of time (0-48h, 14 days), but had significant effect over 30 days. However, the effect of photobiomodulation therapy on thermal discrimination was still controversial, most authors supported no significant improvement. By calculating the effective rate of PBM, it was found that there was no significant difference in the onset time of treatment, whether within or over 6 months. Conclusions The results of this META-analysis show that PBM therapy is effective in the treatment of IAN injures no matter it begins early or later. However, due to the limited number of well-designed RCTs and small number of patients in each study, it would be necessary to conduct randomized controlled trials with large sample size, long follow-up time and more standardized treatment and evaluation methods in the future to provide more accurate and clinically meaningful results.

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Effect of Photobiomodulation (Diode 810 nm) on Long-Standing Neurosensory Alterations of the Inferior Alveolar Nerve: A Case Series Study

Cited by 6 publications

References 24 publications

Mitochondrial Bioenergetic, Photobiomodulation and Trigeminal Branches Nerve Damage, What’s the Connection? A Review

Mitochondrial Bioenergetic, Photobiomodulation and Trigeminal Branches Nerve Damage, What’s the Connection? A Review

Nerve Injury and Photobiomodulation, a Promising Opportunity: A Scoping Review on Laser Assisted Protocols for Lesions in the Oral Region

The effectiveness of photobiomodulation therapy on inferior alveolar nerve injury: A systematic review and META-analysis

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