Role of mitochondria in the differential action of sodium deoxycholate and ursodeoxycholic acid on rat duodenum

Pérez, Adriana; Rivoira, M.A.; Rodríguez, Victoria Eli; Marchionatti, Ana Maria Estivalete; Talamoni, Nori Tolosa de

doi:10.1139/cjpp-2019-0561

Cited by 2 publications

(1 citation statement)

References 52 publications

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“…Bile acids with amphiphilicity modulated the activity of the electron transfer chain, membrane permeability, and biological synthesis to improve mitochondrial functions. UDCA therapy was revealed to improve hepatocyte mitochondrial function in rodent models ( Chen et al, 2019 ; Pérez et al, 2021 ). Despite preclinical research studies, clinical evidence that UDCA depends on the mitochondria to treat NAFLD was still lacking.…”

Section: Possible Mechanisms Of Udca In Nafldmentioning

confidence: 99%

Understanding the role of ursodeoxycholic acid and gut microbiome in non-alcoholic fatty liver disease: current evidence and perspectives

Mao,

Lin,

Zhang

et al. 2024

Front. Pharmacol.

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Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, resulting in a huge medical burden worldwide. Accumulating evidence suggests that the gut microbiome and bile acids play pivotal roles during the development of NAFLD. Patients with NAFLD exhibit unique signatures of the intestinal microbiome marked by the priority of Gram-negative bacteria, decreased ratio of Firmicutes/Bacteroidetes (F/B), and increased Prevotella and Lachnospiraceae. The intestinal microbiota is involved in the metabolism of bile acids. Ursodeoxycholic acid (UDCA) is a key determinant in maintaining the dynamic communication between the host and gut microbiota. It generally shows surprising therapeutic potential in NAFLD with several mechanisms, such as improving cellular autophagy, apoptosis, and mitochondrial functions. This action is based on its direct or indirect effect, targeting the farnesoid X receptor (FXR) and various other nuclear receptors. This review aims to discuss the current studies on the involvement of the microbiome–UDCA interface in NAFLD therapy and provide prospective insights into future preventative and therapeutic approaches for NAFLD.

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Section: Possible Mechanisms Of Udca In Nafldmentioning

confidence: 99%

Understanding the role of ursodeoxycholic acid and gut microbiome in non-alcoholic fatty liver disease: current evidence and perspectives

Mao,

Lin,

Zhang

et al. 2024

Front. Pharmacol.

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Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction

Pérez

Mukdsi

Valdez

et al. 2023

Can. J. Physiol. Pharmacol.

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We have studied the effects of naringin (NAR), a flavonoid from citric fruits, on morphology, ultrastructure and function of the kidney in streptozotocin (STZ)-induced diabetic rats. Two groups of animals were used: 1) control rats, and 2) STZ rats (60 mg STZ/kg b.w.). At 3 days after induction, one group of STZ-treated rats received 40 mg NAR/kg b.w. daily. NAR blocked completely alterations in the biochemical renal markers in STZ rats except the increase in serum urea that was partially avoided by the flavonoid. NAR ameliorated the kidney morphological lesions from STZ rats. STZ treatment induced round and smaller mitochondria, which was avoided by NAR. Citrate synthase, isocitrate and malate dehydrogenases, enzyme activities of the Krebs cycle, were decreased in STZ rats. NAR abolished this decrease in the latter proteins. NAR also prevented a decrease in the ATP synthase activity of the mitochondria from renal cortex by about 49% in STZ rats, returning the enzyme activity to control values. The nephroprotection caused by NAR is mediated through counteraction of oxidative stress in mitochondria of proximal tubules. NAR might be a therapeutic strategy to reduce the complication of diabetic nephropathy in type 1 diabetic patients.

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Role of mitochondria in the differential action of sodium deoxycholate and ursodeoxycholic acid on rat duodenum

Cited by 2 publications

References 52 publications

Understanding the role of ursodeoxycholic acid and gut microbiome in non-alcoholic fatty liver disease: current evidence and perspectives

Understanding the role of ursodeoxycholic acid and gut microbiome in non-alcoholic fatty liver disease: current evidence and perspectives

Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction

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