Isolation and characterization of the major centipede allergen Sco m 5 from Scolopendra subspinipes mutilans

The present review article explains venoms from various centipede species with their biomedical and pharmacological properties. Centipede venom is a natural source of bioactive proteins, peptides and other small molecules. These use venoms as defense arsenals to paralyze prey. This review paper sketch out important physiological effects like platelet aggregation, anticoagulant, phospholipase A2 and trypsin inhibiting activity. Centipede venom toxins selectively bind Kv2.1 channel and block them. Centipede venom disrupts cardiovascular, respiratory, muscular and nervous systems by targeting the broadly distributed KCNQ channels. It also signifies toxin-voltage-gated integrations and its inhibition. These peptides can be used for developing drugs for treatments as well as bio-insecticides for insect control.

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Antihepatoma peptide, scolopentide, derived from the centipede scolopendra subspinipes mutilans

Hu¹,

Liu²,

Zhang³

et al. 2023

World J Gastroenterol

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Isolation and characterization of the major centipede allergen Sco m 5 from Scolopendra subspinipes mutilans

Cited by 3 publications

References 31 publications

A systematic review of allergen cross-reactivity: Translating basic concepts into clinical relevance

A systematic review of allergen cross-reactivity: Translating basic concepts into clinical relevance

Centipede Venom Toxins and Its Biomedical and Pharmacological Properties

Antihepatoma peptide, scolopentide, derived from the centipede scolopendra subspinipes mutilans

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