Common Signal Transduction Molecules Activated by Bacterial Entry into a Host Cell and by Reactive Oxygen Species

Bonavita, Raffaella; Laukkanen, Mikko O.

doi:10.1089/ars.2019.7968

Cited by 2 publications

(2 citation statements)

References 198 publications

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“…ROS has been a key factor in destroying bacterial cell walls. Due to the local interaction of ZnO NPs, the membrane permeability increases, as well as the absorption of dissolved toxic Zn+, which leads to the weakening of mitochondrial function, the release of genes expressing oxidative stress, leading to cell growth inhibition and death (Bonavita & Laukkanen, 2021).…”

Section: Application Of Zno Nmts In Bacteria and Its Mechanismmentioning

confidence: 99%

Biological mechanism of ZnO nanomaterials

et al. 2023

J of Applied Toxicology

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Modern nanotechnology has made zinc oxide nanomaterials (ZnO NMts) multifunctional, stable, and low cost, enabling them to be widely used in commercial and biomedical fields. With its wide application, the risk of human direct contact and their release into the environment also increases. This review aims to summarize the toxicity studies of ZnO NMts in vivo, including neurotoxicity, inhalation toxicity, and reproductive toxicity. The antibacterial and antiviral mechanisms of ZnO NMts in vitro and the toxicity to eukaryotic cells were summarized. The summary found that it was mainly related to reactive oxygen species (ROS) produced by oxidative stress. It also discusses the potential harm to body and the favorable prospects of the widespread use of antibacterial and antiviral in the future medical field. The review also emphasizes that the dosage and use method of ZnO NMts will be the focus of future biomedical research.

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Section: Application Of Zno Nmts In Bacteria and Its Mechanismmentioning

confidence: 99%

Biological mechanism of ZnO nanomaterials

et al. 2023

J of Applied Toxicology

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“…These ROS can influence various cell fate decisions and signal transduction pathways, for example, through reversible oxidation and reduction of amino acids (Holmström and Finkel 2014). At the low physiological levels in the nanomolar range, these ROS are key signalling agents involved in metabolic regulation, activating numerous growth-supporting pathways (Bonavita and Laukkanen 2021; Sies 2017; Thannickal and Fanburg 2000). Applying sublethal levels of H 2 O 2 to Pseudomonas putida reconfigures intracellular metabolism by redirecting periplasmic glucose processing to cytoplasmic oxidation and significantly increasing NADPH-forming fluxes to energize the glutathione system and decrease H 2 O 2 (Nikel et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

L-norepinephrine induces ROS formation but alters microbial community composition by altering cellular metabolism

Bains

Dahal

Manna

et al. 2022

Preprint

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Catecholamines, such as L-norepinephrine (L-NE), are naturally present in the human gut and are discharged into the sewage. The bioactivity of L-NE can significantly alter the speciation and function of the microbial community by stimulating bacterial growth and producing H2O2. The accompanying changes in intracellular metabolism could significantly impact biological wastewater treatment processes, but they have remained unexplored. We investigate the alterations by L-NE and two other Catecholamines (Dopamine, and L-Dopa) to microbial consortia sourced from a dairy farm settling pond (FS) and the activated sludge of a municipal wastewater treatment plant (MS). We contrast the effect of the catecholamines on these mixed microbial communities with dextrose, a readily degradable substrate, and elevated levels of intracellular H2O2 through high dissolved oxygen (HDO) perturbations and exogenous applications of paraquat (PQ) and hydrogen peroxide (H2O2). The microbial community composition in different catecholamines was similar to the Dextrose treatment. However, there were significant changes in the PQ and H2O2 supplemented systems. In addition, the functional potential of the microbial communities with catecholamines and Dextrose were similar and provided insight into metabolic shifts from the control systems. While exogenous H2O2 increased the abundance of Rhodocyclaceae, Flavobacteriaceae and Chitinophagaceae and others, L-NE paralleled dextrose by increasing Pseudomonadaceae, Moraxellaceae, and Sphingobacteriaceae in the microbial consortia. A number of protein functions related to oxidoreductase, peroxidase, and catalase activities, ATP and FAD/FADH2 binding, nitrate reductase, and glutamate-ammonia ligase activity were differentially expressed by L-NE over dextrose, but many of the ROS-scavenging functions were overexpressed in the exogenous H2O2 treatment over L-NE. A proteome-constrained flux balance analysis showed that in comparison to dextrose, L-NE increased the fluxes of gluconeogenesis, glycolysis, oxidative stress metabolism, and glutamate metabolism. L-NE increases stress tolerance and microbial growth by upregulating the activities of oxidative stress mitigating enzymes (catalase and thioredoxin) and nitrogen assimilation activities (glutamine formation).

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Common Signal Transduction Molecules Activated by Bacterial Entry into a Host Cell and by Reactive Oxygen Species

Cited by 2 publications

References 198 publications

Biological mechanism of ZnO nanomaterials

Biological mechanism of ZnO nanomaterials

L-norepinephrine induces ROS formation but alters microbial community composition by altering cellular metabolism

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