Frontal lobe growth is impaired in fetuses with congenital heart disease

Paladini, D.; Finarelli, A.; Donarini, G.; Parodi, Stefano; Lombardo, Valentina; Tuo, Giulia; Birnbaum, R.

doi:10.1002/uog.22127

Cited by 9 publications

(18 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, reduced frontal lobe growth was more obvious than HC. Impaired frontal lobe development is also noted in fetuses with congenital heart defect [ 12 ] and Down syndrome [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…FAPD and OFD were measured retrospectively on the trans-ventricle view by one operator (Fig. 1 ) [ 12 ]. We assumed that the posterior margin of the cavum septum pellucidum (CSP) represents the boundary between the frontal lobe region and the remaining brain regions.…”

Section: Methodsmentioning

confidence: 99%

“…However, the limited convenience of three-dimensional ultrasonography has impeded its clinical applications. The frontal antero-posterior diameter (FAPD)/occipito-frontal diameter (OFD) ratio has been recently used to evaluate frontal lobe development in fetuses with congenital heart disease [ 12 ]. FAPD was measured from the inner line of the frontal bone to the posterior edge of the CSP along the fetal brain midline, which represents the frontal lobe of the fetal cerebrum.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Frontal lobe development in fetuses with growth restriction by using ultrasound: a case–control study

Ruan

Zheng

et al. 2022

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

Background Fetal growth restriction (FGR) occurs in up to 10% of pregnancies and is a leading cause of perinatal mortality and neonatal morbidity. Three-dimensional ultrasonography of intracranial structure volume revealed significant differences between fetuses with FGR and appropriate for gestational age (AGA) fetuses. We aimed to compare the frontal lobe development between fetuses with FGR and appropriately grown fetuses and evaluate the impact of fetal circulatory redistribution (FCR) on frontal lobe development in fetuses with FGR. Methods We performed a case–control study at our institution from August 2020 to April 2021. The frontal antero-posterior diameter (FAPD) and occipito-frontal diameter (OFD) were measured on the trans-ventricle view and we calculated the Z-scores for FAPD and OFD standardized for gestational age (GA) and transverse cerebellar diameter (TCD) by performing a standard regression analysis followed by weighted regression of absolute residual values in appropriately grown fetuses. We calculated the FAPD/OFD ratio as 100 × FAPD/OFD and FAPD/HC (head circumference) as 100 × FAPD/HC. To compare intracranial parameters, we randomly selected a control group of appropriately grown fetuses matched with the FGR group at the time of ultrasonography. We performed between-group comparisons of the FAPD Z-score, OFD Z-score, FAPD/OFD ratio and FAPD/HC. Similarly, we compared intracranial parameters between fetuses with FGR with and without FCR. Results FAPD/OFD ratio was curvilinear related to all the independent variables (GA, BPD, FL, and TCD). Compared with appropriately grown fetuses, fetuses with FGR showed a significantly lower FAPD/OFD ratio, FAPD Z-score, and FAPD/HC. There was no significant difference in the FAPD Z-score, FAPD/OFD ratio, and FAPD/HC between FGR fetuses with and without FCR. Conclusions The FAPD/OFD ratio varied during pregnancy, with a mild reduction before and a mild increase after about 33 gestational weeks. Fetuses with FGR showed reduced frontal lobe growth; moreover, fetal frontal lobe development disorders were not significantly different in fetuses with FCR. Trial registration Date: 09–27-2017; Number: [2017]239.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Frontal lobe development in fetuses with growth restriction by using ultrasound: a case–control study

Ruan

Zheng

et al. 2022

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

“…Thus, impairment of fetal frontal lobe in the intrauterine period may lead to future behavioral and functional problems 13 Fetal frontal lobe development may be affected by obstetric complications like fetal growth restriction and fetal congenital heart diseases. 14,15 However, the knowledge related to the effect of maternal diabetes on fetal frontal lobe development is not sufficient.…”

mentioning

confidence: 99%

The impact of gestational diabetes on the development of fetal frontal lobe: A case–control study from a tertiary center

Sahin,

Tanacan,

Serbetci

et al. 2023

J of Clinical Ultrasound

View full text Add to dashboard Cite

PurposeTo determine the effects of gestational diabetes mellitus (GDM) on fetal frontal lobe development.MethodsThis study was conducted prospectively between May 2023 and August 2023 in Ankara City Hospital perinatology clinic. Maternal age, maternal body mass index (BMI), gestational week (GW), biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), femur length (FL), estimated fetal weight (EFW), frontal antero‐posterior diameter (FAPD), occipito‐frontal diameter (OFD), FAPD/OFD ratio, and FAPD/HC ratio, were compared between GDM (n = 40) and low risk controls (n = 56).ResultsThe mean maternal age was found higher in the GDM group compared to control group (p = 0.002). Maternal BMI was significantly higher in the GDM group than the control group (p = 0.01). Abdominal circumference (AC) was significantly higher in the GDM group compared to control group (p = 0.04). EFW was significantly higher in the GDM group compared to control group (p = 0.04). FAPD/OFD ratio was found to be higher in the GDM group than in the control group (p = 0.001). Among GDM patients, no statistically significant difference was found in the ultrasound measurements between the groups receiving insulin treatment and those without treatment. According to the correlation analysis results a moderate, positive, and statistically significant correlation was present between FAPD/OFD and GDM. In perinatal outcomes, the rate of neonatal intensive care unit admission was significantly higher in the GDM group.DiscussionFetal frontal lobe development seems to be affected by GDM.

show abstract

“…Hence, our report included only cases with large choroid plexus cysts and did not include any cases of ganglionic eminence cavitation, as hypothesized by Prof. Malinger who might have hesitated before making such assumptions, considering the credit that should be given to any researcher, especially one deeply involved in the assessment of the fetal brain, as in this case [2][3][4][5] .…”

mentioning

confidence: 99%