Shape Memory and Osteogenesis Capabilities of the Electrospun Poly(3-Hydroxybutyrate-<i>co</i>-3-Hydroxyvalerate) Modified Poly(<scp>l</scp>-Lactide) Fibrous Mats

Wang, Xianliu; Yan, Hongyuan; Shen, Yanbing; Tang, Han; Yi, Baolian; Qin, Chunping; Zhang, Yanzhong

doi:10.1089/ten.tea.2020.0086

Cited by 21 publications

(17 citation statements)

References 48 publications

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“…The obtained results from differentiation section showed that the degree of bone differentiation of ADSCs on C‐PLLA/PHB nanofibrous scaffold significantly improved compared to the control group. Although there is no similar article examining the differentiation potential of MSCs when cultured on PLLA/PHB nanofibers, improvement of MSCs osteogenic differentiation potential when cultured on PLLA/PHBV was previously reported by Wang et al 34 Their results obtained by ALP activity, calcium content, and bone‐related gene expression evaluations demonstrated that PLLA/PHBV (7:3) has great potential to use in bone tissue repair and regeneration compared to the PLLA nanofibrous scaffold. But our results, in addition to confirming osteoconductive capacity of PLLA/PHB nanofibrous scaffold, demonstrated that if the PLLA and PHB polymers are not premixed, and they are poured into two separate syringes, they can present a better osteoconductivity property.…”

Section: Discussionmentioning

confidence: 89%

Different osteoconductivity of PLLA/PHB composite nanofibers prepared by one‐ and two‐nozzle electrospinning

Sabouri

Rezaie²,

Enderami

et al. 2021

Polymers for Advanced Techs

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Electrospinning is a method that has a high potential for use in tissue engineering due to its simplicity, cheapness, versatility, and high applicability for preparing of composite nanofibrous scaffolds. In this study, nanofibrous scaffolds were made of poly‐l‐lactic acid (PLLA) and Polyhydroxybutyrate (PHB) polymers by electrospinning single‐nozzle (combined polymers: C‐PLLA/PHB) and two‐nozzle (separated polymers: S‐PLLA/PHB). Constructed scaffolds were characterized using SEM, in vitro degradation, cell attachment, protein adsorption, and nontoxicity assays. Then, scaffolds osteoconductive capacity was investigated by culturing adipose‐derived stem cells (ADSCs) and by evaluating common osteogenic markers. Obtained results displayed that fibers diameter, scaffold degradation, and biocompatibility of S‐PLLA/PHB nanofibrous scaffold were increased compared to the C‐PLLA/PHB nanofibers. In addition, significantly increased alkaline phosphatase (ALP) activity, calcium content, and osteogenic‐related gene expression were also observed in the ADSCs cultured on S‐PLLA/PHB nanofibrous scaffold compared to the cultured cells on C‐PLLA/PHB nanofibrous scaffold. Overall, this study shows that using two‐nozzle electrospinning to constructing PLLA/PHB nanofibrous scaffold can improve its osteoconductive capacity, and also its combination with ADSCs can be a promising candidate to use in bone tissue engineering.

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Section: Discussionmentioning

confidence: 89%

Different osteoconductivity of PLLA/PHB composite nanofibers prepared by one‐ and two‐nozzle electrospinning

Sabouri

Rezaie²,

Enderami

et al. 2021

Polymers for Advanced Techs

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“…Moreover, polylactide polymers possess an SME if properly programmed. To reach suitable characteristics in terms of toughness and T g , polylactides were combined and/or blended with other materials [81]. On-command on/off switching of cell polarized motility and alignment [82] Poly(lactide-cotrimethylene carbonate) Schwann cells (SCs)…”

Section: Bone Regenerationmentioning

confidence: 99%

Shape-Memory Polymers Hallmarks and Their Biomedical Applications in the Form of Nanofibers

Pisani

Modena

Dorati

et al. 2022

IJMS

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Shape-Memory Polymers (SMPs) are considered a kind of smart material able to modify size, shape, stiffness and strain in response to different external (heat, electric and magnetic field, water or light) stimuli including the physiologic ones such as pH, body temperature and ions concentration. The ability of SMPs is to memorize their original shape before triggered exposure and after deformation, in the absence of the stimulus, and to recover their original shape without any help. SMPs nanofibers (SMPNs) have been increasingly investigated for biomedical applications due to nanofiber’s favorable properties such as high surface area per volume unit, high porosity, small diameter, low density, desirable fiber orientation and nanoarchitecture mimicking native Extra Cellular Matrix (ECM). This review focuses on the main properties of SMPs, their classification and shape-memory effects. Moreover, advantages in the use of SMPNs and different biomedical application fields are reported and discussed.

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“…A device made of such materials can be manufactured as a small, easy-to-implant element that will undergo specific changes in the patient’s body once it has been implanted due to the temperature changes in the surrounding environment [ 139 ]. The presented family of “smart” materials, including polyesters, have proven to have interesting applications, including as biodegradable medical sutures, scaffolds that become elastic, or stents that will expand once implanted [ 140 , 141 ].…”

Section: Tissue Engineeringmentioning

confidence: 99%

Special Features of Polyester-Based Materials for Medical Applications

Darie-Niță¹,

Râpă

Frąckowiak

2022

Polymers

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This article presents current possibilities of using polyester-based materials in hard and soft tissue engineering, wound dressings, surgical implants, vascular reconstructive surgery, ophthalmology, and other medical applications. The review summarizes the recent literature on the key features of processing methods and potential suitable combinations of polyester-based materials with improved physicochemical and biological properties that meet the specific requirements for selected medical fields. The polyester materials used in multiresistant infection prevention, including during the COVID-19 pandemic, as well as aspects covering environmental concerns, current risks and limitations, and potential future directions are also addressed. Depending on the different features of polyester types, as well as their specific medical applications, it can be generally estimated that 25–50% polyesters are used in the medical field, while an increase of at least 20% has been achieved since the COVID-19 pandemic started. The remaining percentage is provided by other types of natural or synthetic polymers; i.e., 25% polyolefins in personal protection equipment (PPE).

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Shape Memory and Osteogenesis Capabilities of the Electrospun Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) Modified Poly(l-Lactide) Fibrous Mats

Cited by 21 publications

References 48 publications

Different osteoconductivity of PLLA/PHB composite nanofibers prepared by one‐ and two‐nozzle electrospinning

Different osteoconductivity of PLLA/PHB composite nanofibers prepared by one‐ and two‐nozzle electrospinning

Shape-Memory Polymers Hallmarks and Their Biomedical Applications in the Form of Nanofibers

Special Features of Polyester-Based Materials for Medical Applications

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