2019
DOI: 10.1016/j.jid.2019.03.400
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324 A potential role of galectin-7 as a stabilizer for IL-4/IL-13-induced barrier disruption in atopic dermatitis

Abstract: An epidemiological study found that higher frequencies of carbonylated proteins (CPs) in corneocytes are closely correlated with the loss of skin hydration. On the other hand, a high frequency of CPs in reconstructed human epidermal equivalents (RHEEs) exposed to low humidity at their surface was also observed according to the generation of reactive oxygen species. Although those results elucidated the relationship between skin hydration and protein oxidation in the stratum corneum, it did not identify whether… Show more

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