(322) Sleep mediates the relationship between central sensitization and clinical pain

Burton, Elizabeth C.; Campbell, C. M.; Robinson, Marc; Bounds, S.; Buenaver, L.; Smith, Michael T.

doi:10.1016/j.jpain.2016.01.229

Cited by 6 publications

(3 citation statements)

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“…Central sensitisation can be moderated or triggered by psychological or behavioural aspects 5,22,36,78,103 via shared neural circuitries and interconnected neuro-immune pathways 78 . Both psychological (e.g., depression) and behavioural (e.g., poor sleep) stressors have been associated with measures of central sensitisation 1,14,16,85,104 , and frequently occur together in chronic pain conditions including chronic LBP 29,52,81,123 . Whether or not the coexistence of sensitisation, psychological and/or behavioural features in the early phase of acute LBP is related to poor outcome has not been tested.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Are Signs of Central Sensitization in Acute Low Back Pain a Precursor to Poor Outcome?

Klyne

Moseley

Sterling

et al. 2019

The Journal of Pain

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights  Central sensitisation presents in some but not all individuals with acute back pain  Presence of central sensitisation early does not necessarily precede poor outcome  Early sensitisation precedes poor outcome when combined with psychological factors

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Section: Accepted Manuscriptmentioning

confidence: 99%

Are Signs of Central Sensitization in Acute Low Back Pain a Precursor to Poor Outcome?

Klyne

Moseley

Sterling

et al. 2019

The Journal of Pain

View full text Add to dashboard Cite

show abstract

“…32 Pain sensations can become distorted as a result, meaning the receptor thresholds are decreased, or more sensitive to, noxious stimuli. 33 Distortions of pain resulting from central sensitization clearly affect the individual pain experience through pain hypersensitivity, hyperalgesia, aftersensations, and allodynia. 32 Both concepts canlead to avoidance behaviors and fear, resulting in further physical and mental deconditioning.…”

Section: Genetic Vulnerabilitiesmentioning

confidence: 99%

The Biopsychosocial Model of the Assessment, Prevention, and Treatment of Chronic Pain

Bevers

Watts

Kishino³

et al. 2016

US Neurology

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The biopsychosocial model has been demonstrated to be the most heuristic approach to chronic pain assessment, prevention, and treatment. Currently, this model also provides the best foundation for tailoring the most comprehensive pain management program for each specific patient. Chronic pain patients have an increased risk for developing deficits in physical functioning, emotional reactivity, and cognition. Interdisciplinary treatment, based on the biopsychosocial model, is vital to address these multifaceted issues facing chronic pain sufferers. These interdisciplinary pain management strategies have progressed with advancements in science and technology in an attempt to provide the best possible outcomes for pain patients. However, while research has made enormous advances, there are still some clinical research gaps to be addressed. This article will begin with a historical overview of pain management in order to demonstrate the evolution in theory from ancient practices to the modern biopsychosocial model. Additionally, functional restoration and other early interdisciplinary intervention programs will be highlighted for their importance and effectiveness in chronic pain management, assessment, and prevention.

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“…Sleep quality influences pain and central sensitization, and poor sleep adversely affects both domains. 41 Sleep deprivation promotes hyperalgesia and anxiety. 42 …”

Section: Potential Associated Factors and Pathophysiologymentioning

confidence: 99%

Provoked vestibulodynia: current perspectives

Henzell¹,

Berzins²,

Langford³

2017

IJWH

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Provoked vestibulodynia (PVD) refers to vulvar pain of at least 3 months duration, localized to the vestibule, provoked by touch and sexual activity and occurring in the absence of a clear identifiable cause. The clinical spectrum ranges from mild with distressing discomfort through to severe and disabling pain. Current understanding is that PVD is one of many chronic pain conditions characterized by sensitization of peripheral and central nociceptive pathways, with pain arising due to dysfunctional neuronal activity in the absence of painful stimuli. Pathophysiology is not well understood but is likely a complex interplay of environmental, genetic, psychological and immune factors. Care is multidisciplinary and follows general principles of chronic pain management with the addition of specific therapy tailored to address pelvic floor overactivity, and sexual and relationship difficulties. More recently, the therapeutic use of placebo is gaining traction in chronic pain research and is a very promising adjunctive therapy. The majority of women with PVD are managed outside of tertiary clinic settings, and care depends on availability and affordability of specialized services; however, much can be done by the primary health provider. PVD is common, and highly treatable, especially with early intervention, but unfortunately, many clinicians are unaware of this condition, and the biggest hurdle for women accessing treatment is obtaining a diagnosis. With treatment, most women can expect significant improvement, often with fairly simple interventions, although some women will benefit from referral to specialized centers. The aims of this article are twofold: firstly, to summarize current literature concerning PVD pathophysiology and management; secondly, to provide a framework for clinicians unfamiliar with vulvar medicine to understand and manage PVD.

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(322) Sleep mediates the relationship between central sensitization and clinical pain

Cited by 6 publications

References 0 publications

Are Signs of Central Sensitization in Acute Low Back Pain a Precursor to Poor Outcome?

Are Signs of Central Sensitization in Acute Low Back Pain a Precursor to Poor Outcome?

The Biopsychosocial Model of the Assessment, Prevention, and Treatment of Chronic Pain

Provoked vestibulodynia: current perspectives

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