322 Involvement of endogenous opioids in the antinociception induced by sweet substance intake

Segato, E.N.; Segato, F.N.; Castro-Souza, C.; Morato, Sílvio; Coimbra, Norberto Cysne

doi:10.1016/s0167-8760(98)90321-x

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“…The present results suggest that chronic intake of sweet substances, such as sucrose, induces clearly significant analgesic effects, and these findings are in accordance with the literature (Bergmann et al 1985, Segato et al 1997, Segato et al 1998, Irusta et al 2001. Interestingly, our data pointed out to a significant antinociceptive effect after intake of sucrose in more concentrated solution (250 g/l) compared to other less concentrated palatable solutions, used in the present work.…”

Section: Discussionsupporting

confidence: 93%

Effect of chronic intake of sweet substance on nociceptive thresholds and feeding behavior of Rattus norvegicus (Rodentia, Muridae)

Segato

Rebouças²,

Freitas

et al. 2005

Nutritional Neuroscience

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The investigation of the influence of sweetened food on feeding behavior targeted to non-sucrose nutrients as well as the sensitivity to painful stimuli in isolated and grouped animals is the aim of the present work. The tail withdrawal latencies in the tail-flick test (a spinal reflex) were measured before and immediately after the treatment with tap water or sucrose (62, 125 or 250 g/l). Our findings suggest that: (a) The analgesic effect of sucrose intake depends on the concentration of sucrose solution and on the time during which the solution is consumed; (b) the most effective concentration of sucrose followed by antinociceptive effect was the one of 250 g/l in both isolated and grouped animals; (c) considering the individually caged rats, the intake of sucrose in the highest concentration (250 g/l) was the smallest as compared with the consumption of sucrose in more diluted solutions (62.5 and 125 g/l), but this higher sweetened solution was followed by antinociception; (d) animals treated with concentrated sucrose solution ate smaller quantities of pellets than animals treated with tap water; (e) tonic intake of highly concentrated sweet substance seems to be crucial for the increase of the nociceptive threshold in our model of sweet substance-induced antinociception.

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Section: Discussionsupporting

confidence: 93%