32-P-09-In vitro and in vivo effect of natural clinoptilolite on malignant tumors

Blazi, M. Poljak; Katic, Masa; Kralj, Marijeta; Žarković, Neven; Marotti, Tatjana; Bošnjak, Berislav; Šverko, Višnja; Balog, Tihomir; Pavelić, Krešimir

doi:10.1016/s0167-2991(01)81883-8

Cited by 4 publications

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“…It possesses a biological activity; it can adsorb glucose (24), improve diarrheic syndrome (23), and act as an immunostimulator (25-28). Our previous studies showed that clinoptilolite could be an adjuvant in cancer therapy because of its anticancer, antimetastatic and immunostimulating properties (27,28,32,33). We assume that these effects are consequences of changes in cell signalling influenced by clinoptilolite.…”

Section: Discussionmentioning

confidence: 99%

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A clinoptilolite effect on cell media and the consequent effects on tumor cells in vitro

Katic¹

2006

Front Biosci

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Clinoptilolite is a nontoxic natural zeolite with properties of an ion-exchanger and adsorbent. Earlier studies showed that clinoptilolite could be an adjuvant in cancer therapy. The aim of this study was to define effects of clinoptilolite in cell media on cell viability and activity of key proteins regulating cell survival, cell division and stress response. The number of viable cells, DNA synthesis and activity of EGF-R, PKB/Akt and NF?B was reduced, while apoptosis was increased in cells that were cultured in medium supplemneted with clinoptilolite. These results might be due to adsorbtion of some serum components such as EGF to clinoptilolite. In treated medium without serum the predominant role of clinoptilolite is that of cation exchange, likely affecting calcium levels and calcium-dependent signalling pathways. These results are in line with other data that confirm enhanced apoptosis in cells incubated in treated medium. Together, data presented here demonstrate that clinoptilolite affects cellular microenvironment through mechanisms that are dependent on adsorptive and ion-exchange characteristics of this material.

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Section: Discussionmentioning

confidence: 99%

“…They activate MAPK, PKC and SAPK (30), transcription factors like AP-1 or ΝFκΒ and proinflammatory cytokines IL-1α, IL-6 and TNF-α (31). Very important results show antitumor effect of clinoptilolite and its potential role as adjuvant in anticancer therapy (27,28,32,33).…”

Section: Introductionmentioning

confidence: 99%

A clinoptilolite effect on cell media and the consequent effects on tumor cells in vitro

Katic¹

2006

Front Biosci

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“…As antitumor active materials, natural Zeolite, particularly clinoptilolite, is proved to possess a potential role as adjuvant chemotherapy applied after initial treatment for cancer, especially to suppress secondary tumor formation [ 53 – 55 ]. Its micronized form is found to interfere with the lipid peroxidation in the liver of cancer-bearing mice leading to a decrease in the tumor size, improvement of the overall health status, and prolonged life span.…”

Section: Introductionmentioning

confidence: 99%

Novel Synthesis Method of Micronized Ti-Zeolite Na-A and Cytotoxic Activity of Its Silver Exchanged Form

Youssef

Hegazy

Abo-Almaged

et al. 2015

Bioinorganic Chemistry and Applications

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The core-shell method is used as a novel synthetic process of micronized Ti-Zeolite Na-A which involves calcination at 700°C of coated Egyptian Kaolin with titanium tetrachloride in acidic medium as the first step. The produced Ti-coated metakaolinite is subjected to microwave irradiation at low temperature of 80°C for 2 h. The prepared micronized Ti-containing Zeolites-A (Ti-Z-A) is characterized by FTIR, XRF, XRD, SEM, and EDS elemental analysis. Ag-exchanged form of Ti-Z-Ag is also prepared and characterized. The Wt% of silver exchanged onto the Ti-Zeolite structure was determined by atomic absorption spectra. The in vitro cytotoxic activity of Ti-Z-Ag against human hepatocellular carcinoma cell line (HePG2), colon cell line carcinoma (HCT116), lung carcinoma cell line (A549), and human Caucasian breast adenocarcinoma (MCF7) is reported. The results were promising and revealed that the exchanged Ag form of micronized Ti-Zeolite-A can be used as novel antitumor drug.

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“…It is recognized, however, that zeolites must be considered only as adjuvants in a possible anticancer therapy. Most research on the use of clinoptilolite in oncology has been carried out in the laboratories of the Division of Molecular Medicine, Ruer Bošković Institute, Zagreb (Croatia) (Poljak-Blaži et al, 2001;Pavelić et al, 2001bPavelić et al, , 2002Ž arković et al, 2003;Katić et al, 2006). The CPT sample used in all the studies was a Slovakian material, finely powdered by tribomechanical micronization.…”

Section: Z E O L I T E S I N a N T I C A N C E R T H E R A P Ymentioning

confidence: 99%

A critical reconsideration of biomedical and veterinary applications of natural zeolites

Colella¹

2011

Clay miner.

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Natural zeolites have traditionally been used as supplements in animal nutrition with positive effects in terms of either faster growth or reduced incidence of diseases and death. The discovery that natural zeolites may act as drugs or coadjutants in pharmaceutical preparations has greatly enlarged the field of their applications in many sectors of biology and medicine, opening unexpected horizons for either basic or applied research. This review updates the state of the art of research in this sector, focusing on clinoptilolite-rich materials, with two main purposes: (1) trying to rationalize this subject, which is extremely variable and heterogeneous, and (2) raising doubts about unsuitable uses of natural zeolites in the light of their known properties and expected behaviour.

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32-P-09-In vitro and in vivo effect of natural clinoptilolite on malignant tumors

Cited by 4 publications

References 0 publications

A clinoptilolite effect on cell media and the consequent effects on tumor cells in vitro

A clinoptilolite effect on cell media and the consequent effects on tumor cells in vitro

Novel Synthesis Method of Micronized Ti-Zeolite Na-A and Cytotoxic Activity of Its Silver Exchanged Form

A critical reconsideration of biomedical and veterinary applications of natural zeolites

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