31P-nuclear magnetic resonance evidence of abnormal skeletal muscle metabolism in patients with chronic lung disease and congestive heart failure

Tada, Hiroko; Kato, Hitoshi; Misawa, Takuo; Sasaki, Fumihiko; Hayashi, Shin-ichiro; Takahashi, Hitomi; Kutsumi, Yasunori; Ishizaki, Takeshi; Nakai, Toshiko; Miyabo, S

doi:10.1183/09031936.93.05020163

Cited by 54 publications

(7 citation statements)

References 19 publications

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“…Indeed, 31 P MRS established relatively early on that the PCr recovery rate of skeletal muscle decreases with age 19,74,75 as sarcopenia develops. Secondary sarcopenia is also associated with decreased PCr recovery rates, as, for example, revealed in patients with dialysis-dependent chronic kidney disease, 76 chronic lung disease, 77 thyroid disorders, 78 and heart failure. 77 These (patho)physiological observations are corroborated by studies on human skeletal muscle biopsies that also demonstrate an age-dependent decline in the rate of PCr recovery after exercise.…”

Section: Mitochondrial Bioenergeticsmentioning

confidence: 95%

Mitochondrial involvement in sarcopenia

Affourtit,

Carré

2024

Acta Physiologica

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Sarcopenia lowers the quality‐of‐life for millions of people across the world, as accelerated loss of skeletal muscle mass and function contributes to both age‐ and disease‐related frailty. Physical activity remains the only proven therapy for sarcopenia to date, but alternatives are much sought after to manage this progressive muscle disorder in individuals who are unable to exercise. Mitochondria have been widely implicated in the etiology of sarcopenia and are increasingly suggested as attractive therapeutic targets to help restore the perturbed balance between protein synthesis and breakdown that underpins skeletal muscle atrophy. Reviewing current literature, we note that mitochondrial bioenergetic changes in sarcopenia are generally interpreted as intrinsic dysfunction that renders muscle cells incapable of making sufficient ATP to fuel protein synthesis. Based on the reported mitochondrial effects of therapeutic interventions, however, we argue that the observed bioenergetic changes may instead reflect an adaptation to pathologically decreased energy expenditure in sarcopenic muscle. Discrimination between these mechanistic possibilities will be crucial for improving the management of sarcopenia.

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Section: Mitochondrial Bioenergeticsmentioning

confidence: 95%

Mitochondrial involvement in sarcopenia

Affourtit,

Carré

2024

Acta Physiologica

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“…In this issue of the Journal WuYAM et al [1] and TADA et al [2] present two of the first studies of the effe. ct of chronic obstructive pulmonary disease (eOPD) on skeletal muscle metabolism using 31 P-MRS.…”

Section: Application In Energy Metabolismmentioning

confidence: 99%

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confidence: 99%

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Nuclear magnetic resonance spectroscopy: a tool for skeletal muscle metabolic research

Jakobsson¹,

Jorfeldt²

1992

Eur Respir J

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Nuclear magnetic resonance spectroscopy provides non-invasive and non-destructive access to the chemistry of human tissue in situ. Two studies presented in this issue of the Journal [1,2] apply this new technique on skeletal muscle metabolism in patients with chronic lung disease.In the 1940s, E. Purcell and F. Bloch discovered that electromagnetic radio-frequency energy could be used to interact with the magnetic fields of some atomic nuclei. The phenomenon was called nuclear magnetic resonance (NMR). For this discovery, Purcell and Block were awarded the Nobel Prize in 1952. In the 1950s, NMR was developed into NMR spectroscopy, as an instrument for analytical chemistry in vitro. The 1991 Nobel Prize in chemistry was awarded to R.R. Ernst for pioneering further development of the NMR technique, especially high resolution two dimensional spectroscopy.The NMR-principle also proved usable for producing two or three dimensional representations of the proton density in tissue, thereby adding a novel technique for medical imaging called magnetic resonance imaging, (MRI). Later, the principle was also developed for spectroscopy in vivo, magnetic resonance spectroscopy (MRS). MRS in particular requires magnets with large field strength. By development of the super-conducting principle, strong magnets large enough to accommodate the human body have been constructed.

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“…The concomitant decrease in pH would be expected to interfere with the contractile mechanism, thereby contributing to fatigue. Evidence for such an explanation for impaired exercise performance in COPD comes from two recent studies of muscle metabolism, using nuclear magnetic resonance (NMR) spectroscopy, published in a former issue of this journal [41][42][43].…”

Section: Energy Expenditurementioning

confidence: 99%

Weight loss in chronic obstructive pulmonary disease

Muers¹,

Green²

1993

Eur Respir J

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Weight loss occurs in about a third or more disabled patients with chronic obstructive pulmonary disease (COPD), and appears to be a poor prognostic factor. As such, it correlates only weakly with FEV1, transfer factor and other measures of respiratory physiology and is probably, to a certain extent, independent of them. Recent studies of basal metabolic rate (BMR) in COPD using steady-state, non-invasive calorimetry, have shown it to be elevated by 10-20% in up to 40% of such patients. It is likely that this represents true hypermetabolism per kilogram of fat free mass. An elevated BMR cannot be predicted from combinations of detailed lung function tests or arterial gases, as patients with similar physiology have differing BMRs. Thus, although an increased work of breathing is the probable explanation for some of the increase, other factors such as cytokines or possibly drug therapy almost certainly contribute. Muscle loss in weight-losing COPD appears to involve both type I and type II fibres, because of a combination of reduced calorie intake and disuse atrophy. Respiratory muscles share this fibre loss. Review of the controlled studies on nutritional supplementation in COPD suggests that an energy increase of about 30% is needed to achieve substantial weight gain and improve exercise tolerance. Fat-rich supplements have some theoretical advantages. Further work is needed particularly with regard to the determinants of the increased BMR in COPD, and the effect of longer term nutritional supplements on prognosis.

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31P-nuclear magnetic resonance evidence of abnormal skeletal muscle metabolism in patients with chronic lung disease and congestive heart failure

Cited by 54 publications

References 19 publications

Mitochondrial involvement in sarcopenia

Mitochondrial involvement in sarcopenia

Nuclear magnetic resonance spectroscopy: a tool for skeletal muscle metabolic research

Weight loss in chronic obstructive pulmonary disease

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