31P-NMR evaluation of postischemia renal ATP and pH levels after ATP-MgCl2 treatment in rabbits

Purinergic Signaling and Blood Vessels in Health and Disease

“…Adenosine uptake mediates recovery of ATP content in postischemic cultured renal tubular cells (Cadnapaphornchai et al, 1991). Enhanced recovery from acute renal failure in rats by postischemic infusion of ATP-MgCl 2 was described earlier (Osias et al, 1977;Glazier et al, 1978;Siegel et al, 1980;Gaudio et al, 1982;Hirasawa et al, 1983;Sumpio et al, 1984;Wang et al, 1992bWang et al, , 1992dMartin et al, 1992). Renal injury can arise as a consequence of ischemia and reperfusion during renal transplant surgery.…”

“…P1 (adenosine) receptors have been shown to be present on rabbit aortic smooth muscle (Ghai and Mustafa, 1982). In guinea pig aorta, both A 1 and A 2 receptor subtypes were identified (Stoggall and Shaw, 1990), with some evidence for the expression of A 2B receptors (Martin, 1992). A 2 receptors are involved in endothelium-dependent relaxation of rat thoracic aorta (Moritoki et al, 1990;Rose'Meyer and Hope, 1990).…”

The lung and carbon dioxide: implications for permissive and therapeutic hypercapnia

“…Thus, gradual rather than rapid restoration of intracellular pH while cells become re-oxygenated minimises the cellular injury associated with ischaemia-reperfusion. This effect has been labelled the "pH paradox" and was first described for the heart and liver [28][29][30][31][32], but subsequently has also been shown in lung, kidney and brain [33][34][35][36][37][38]. This paradigm led LAFFEY et al [39] to take permissive hypercapnia one step further by deliberately adding CO 2 to the ventilating gas of ischaemic lungs in vivo.…”

Efficacy of recombinant human Hb by31P-NMR during isovolemic total exchange transfusion

“…31 P-NMR spectroscopy is a sensitive, noninvasive probe of oxygen transport to, and the bioenergetic status of, cells, tissues, and organs (1, 2, 6, 7, 9, 12-16, 19, 20) that measures the amounts of compounds [phosphocreatine (PCr), P i , and nucleotide triphosphates (mainly ATP)] involved in oxidative energy metabolism in tissues. For example, P i is the low-energy degradation product of phosphorus metabolism that accumulates during hypoxia or ischemia (2,6,12,13,19).…”