314 Vitamin D supply for Children and Adolescents with cancer in the South of Russia

Abstract

children with sickle cell disease. The secondary aim is to analyse whether there is an association in children with sickle cell disease between health-related quality of life and 1) patient's age, 2) disease severity, and 3) caregiver's sociodemographic characteristics.A retrospective cross-sectional evaluation of TNO-AZL Preschool Children Quality of Life questionnaire (TAPQOL, 0-1 year) and Pediatric Quality of Life Inventory™ (PedsQL™, 2-7 years) data was conducted in children aged 0-7 years, living in the Netherlands. Study participants included caregivers of children with sickle cell disease referred for clinical follow-up at the sickle cell comprehensive care centres at Amsterdam UMC and Erasmus MC Rotterdam between April 2012 and October 2020. Clinical data were obtained from medical records record abstraction. Comparisons were made with previously published normative data on health-related quality of life in the general paediatric population, living in the Netherlands.The study enrolled 136 caregivers of 136 children. On domains where significant differences existed between children with sickle cell disease and the general paediatric population, children with sickle cell disease scored lower with the most extensive impairment in children aged 5-7 years.Multiple regression models showed a significant negative association between age and health-related quality of life. No association was found between health-related quality of life and disease severity or health-related quality of life and sociodemographic characteristics.This study has demonstrated that health-related quality of life declines with age in very young children with sickle cell disease, with an extensive impaired health-related quality of life from 5 years of age when compared to the general paediatric population. This underlines the importance of the identification of high-risk patients with significantly impaired healthrelated quality of life as early in life as possible, to apply appropriate interventions for quality of life improvement. Future research should focus on factors influencing healthrelated quality of life in children with sickle cell disease.