[31] Nitric oxide donor generation from reactions of peroxynitrite

Cr, White; Patel, Rakesh P.; Darley‐Usmar, Victor

doi:10.1016/s0076-6879(99)01093-9

Cited by 12 publications

(8 citation statements)

References 33 publications

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“…These results indicate that PN induces a cGMP-dependent vasodilator response in the hindlimb vascular bed of the cat and are consistent with the hypothesis that PN interacts rapidly with constituents in plasma or tissue to form a compound with ·NO donor-like properties. 45 These results are in agreement with studies in which PN was shown to increase cGMP levels in isolated arteries. 46,47 The results of studies in the cat are consistent with previous studies in the literature showing that PN has vasodilator properties in isolated arteries, the rat isolated perfused heart and in in vivo experiments in the anaesthetized rat.…”

Section: Biologysupporting

confidence: 91%

“…obs., 2006). These results indicate that PN induces a cGMP‐dependent vasodilator response in the hindlimb vascular bed of the cat and are consistent with the hypothesis that PN interacts rapidly with constituents in plasma or tissue to form a compound with ·NO donor‐like properties 45 . These results are in agreement with studies in which PN was shown to increase cGMP levels in isolated arteries 46,47 .…”

Section: Biologysupporting

confidence: 90%

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Cardiovascular Effects of Peroxynitrite

Uppu

Nossaman

Greco³

et al. 2007

Clin Exp Pharma Physio

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SUMMARY1. Peroxynitrite (PN) is formed in biological systems from the reaction of nitric oxide (·NO) with superoxide ( ·) and both exist as free radicals. By itself, PN is not a free radical, but it can generate nitrogen dioxide (·NO 2 ) and carbonate radical ( ·) upon reaction with CO 2 . 2. The reaction of CO 2 constitutes a major pathway for the disposition of PN produced in vivo and this is based on the rapid reaction of PN anion with CO 2 and the availability of CO 2 in both intra-and extracellular fluids. The free radicals ·NO 2 and ·, in combination with ·NO, generated from nitric oxide synthase, can bring about oxidation of critical biological targets resulting in tissue injury. However, the reactions of ·NO 2 , · and ·NO with carbohydrates, protein and non-protein thiols, phenols, indoles and uric acid could result in the formation of a number of nitration and nitrosation products in the vasculature. These products serve as long-acting ·NO donors and, therefore, contribute to vasorelaxant properties, protective effects on the heart, inhibition of leucocyte-endothelial cell interactions and reduction of reperfusion injury.3. Herein, we review the chemistry of PN, the observations that the effects of PN could be mediated by formation of an ·NO donor-like substance and review the physiological and beneficial effects of PN.

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Section: Biologysupporting

confidence: 91%

Section: Biologysupporting

confidence: 90%

Cardiovascular Effects of Peroxynitrite

Uppu

Nossaman

Greco³

et al. 2007

Clin Exp Pharma Physio

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“…Fig. 1) were proposed [47,51,52], such as those involving nitric oxide (18) and superoxide anion or Piloty's acid anion and molecular oxygen:…”

Section: Peroxynitrite and Peroxynitrous Acidmentioning

confidence: 99%

Chemical Effects of Air Plasma Species on Aqueous Solutes in Direct and Delayed Exposure Modes: Discharge, Post-discharge and Plasma Activated Water

Brisset

Pawłat

2015

Plasma Chem Plasma Process

167

121

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The chemical interaction between non-thermal plasma species and aqueous solutions is considered in the case of discharges in humid air burning over aqueous solutions with emphasis on the oxidizing and acidic effects resulting from formed peroxynitrite ONOO -and derived species, such as transient nitrite and stable HNO 3 . The oxidizing properties are mainly attributed to the systems ONOOONOOH tentatively splits into reactive species, e.g., nitronium NO ? and nitrosonium NO 2 ? cations. NO ? which also results from both ionization of Á NO and the presence of HNO 2 in acidic medium, is involved in the amine diazotation/nitrosation degradation processes. NO 2 ? requires a sensibly higher energy than NO ? to form and is considered with the nitration and the degradation of aromatic molecules. Such chemical properties are especially important for organic waste degradation and bacterial inactivation. The kinetic aspect is also considered as an immediate consequence of exposing an aqueous container to the discharge. The relevant chemical effects in the liquid result from direct and delayed exposure conditions. The so called delayed conditions involve both post-discharge (after switching off the discharge) and plasma activated water. An electrochemical model is proposed with special interest devoted to the chemical mechanism of bacterial inactivation under direct or delayed plasma conditions.

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“…Reactive oxygen and nitrogen species are produced in vivo and may act synergistically to form nitrating agents that modify proteins as well as other biomolecules such as thiols, aldehydes, and lipids. 13,14 Specifically, tyrosine residues or free tyrosine can be modified by peroxynitrite, a compound generated by the reaction of superoxide anion and nitric oxide to generate 3-nitrotyrosine (3-NT). Anti-3-NT polyclonal antibodies revealed immunoreactive 3-NT in hallmark lesions of neurodegenerative diseases such as neurofibrillary tangles (NFTs) in AD 4,5,15 and Lewy bodies in Parkinson's disease (PD).…”

mentioning

confidence: 99%

Nitration of Tau Protein Is Linked to Neurodegeneration in Tauopathies

Horiguchi

Uryu

Giasson

et al. 2003

The American Journal of Pathology

180

118

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Oxidative and nitrative injury is implicated in the pathogenesis of Alzheimer's disease (AD) and Down syndrome (DS), but no direct evidence links this type of injury to the formation of neurofibrillary tau lesions. To address this, we generated a monoclonal antibody (mAb), n847, which recognizes nitrated tau and ␣-synuclein. n847 detected nitrated tau in the insoluble fraction of AD, corticobasal degeneration (CBD), and Pick's disease (PiD) brains by Western blots. Immunohistochemistry (IHC) showed that n847 labeled neurons in the hippocampus and neocortex of AD and DS brains. Double-label immunofluorescence with n847 and an anti-tau antibody revealed partial co-localization of tau and n847 positive tangles, while n847 immmunofluorescence and Thioflavin-S double-staining showed that a subset of n847-labeled neurons were Thioflavin-S-positive. In addition, immuno-electron microscopy revealed that taupositive filaments in tangle-bearing neurons were also labeled by n847 and IHC of other tauopathies showed that some of glial and neuronal tau pathologies in CBD, progressive supranuclear palsy, PiD, and frontotemporal dementia with parkinsonism linked to chromosome 17 also were n847-positive. Finally, nitrated and Thioflavin-S-positive tau aggregates were generated in a oligodendrocytic cell line after treatment with peroxynitrite. Taken together, these findings imply that nitrative injury is directly linked to the formation of filamentous tau inclusions. (Am J

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[31] Nitric oxide donor generation from reactions of peroxynitrite

Cited by 12 publications

References 33 publications

Cardiovascular Effects of Peroxynitrite

Cardiovascular Effects of Peroxynitrite

Chemical Effects of Air Plasma Species on Aqueous Solutes in Direct and Delayed Exposure Modes: Discharge, Post-discharge and Plasma Activated Water

Nitration of Tau Protein Is Linked to Neurodegeneration in Tauopathies

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