30th Annual Meeting of the International Society of Blood Purification (ISBP)

Staffolani, Emiliano; Nicolais, Rebeca; Villahermosa, Simone Manca di; Galli, Diego; Postorino, Massimiliano; Daniele, Nicola Di; Tessitore, Nicola; Santoro, Antonio; Panzetta, Giovanni; Wizemann, V.; Pérez‐García, Rafael; Ara, Jorge Martínez; Perrone, B; Mantovani, William; Poli, A.; Cantaluppi, V.; Gai, M.; Canneyt, Koen Van; Eloot, Sunny; Vanholder, Raymond; Segers, Patrick; Verdonck, Pascal; Biesen, Wim Van; Polak−Jonkisz, Dorota; Purzyc, Leszek; Cortell, Stanley; Gong, Dehua; Daxi, Ji; Zhu, Dawei; Xu, Bin; Liu, Zhihong; Jones, James; Leonard, Edward F.; Sandhu, Gagangeet; Winkel, Gary; Levin, Nathan W.; Kurultak, İlhan; Öztürk, Ramazan; Kızılgöz, Volkan; Çeri, Mevlüt; Kinalp, Can; Evrenkaya, T.Rıfkı; Schiffl, Helmut; Baldwin, Ian; Fealy, Nigel; Carty, Paula; Boyle, Martin; Kim, Inbyung; Bellomo, Rinaldo; Gonçalves, Simone; Lago, Eduardo Andreazza Dal; Moraes, Thyago Proença de; Kloster, Sandra Contador; Boros, Gustavo André Boeing; Colombo, Monica; Raboni, Lenisa; Olandoski, Márcia; Fernandes, Natália; Filho, José C. Divino; Pécoits-Filho, Roberto; Rodrigues, Silvia; Batista, Giuseppe B.; Ingberman, Max; Nakao, Lia S.; Sjöberg, Bertil; Qureshi, Abdul Rashid; Anderstam, Björn; Alvestrand, Anders; Bárány, Peter; Schmidt, Julius J.; Hafer, Carsten; Clajus, Christian; Hadem, Johannes; Beutel, Gernot; Schmidt, Bernhard M.W.; Kielstein, Jan T.; Gil, Hyo‐Wook; Seok, Su-Jin; Hong, Jungrak; Jeong, Mihye; Hong, Sae‐Yong; Bolasco, Piergiorgio; Contu, A.; Meloni, P; Vacca, Dorio; Murtas, Stefano; Ponce, Pedro; Marcelli, Daniele; Guerreiro, António; Grassmann, Aileen; Gonçalves, Carlos Alberto; Scatizzi, Laura; Bayh, Inga; Stopper, Andrea; Ricardo-da-Silva, Jorge M.; Lee, Kyungsoo; Mun, Cho Hay; Min, Byoung Goo; Aniort, Julien; Petitclerc, Thierry; Créput, Caroline; Chua, Horng-Ruey; Ho, Lisa M.; Collins, Allison; Allsep, Helen; Mengensatzproduktion, Satz; Basel, Druck Reinhardt Druck

doi:10.1159/000345376

Cited by 1 publication

(1 citation statement)

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“…After screening the title and abstract, we excluded 177 articles per our study selection criteria earlier. Full texts of the remaining 27 articles were reviewed; 16 articles were excluded for the following reasons: four were review articles [25][26][27][28], four applied a different intervention [29][30][31][32], seven did not include patients with UP [15,[33][34][35][36][37][38], and one was a retrospective study [39]. Finally, 11 RCTs were included in the meta-analysis (Figure 1) [24,[40][41][42][43][44][45][46][47][48][49].…”

Section: Study Characteristicsmentioning

confidence: 99%

Effects of Uremic Clearance Granules in Uremic Pruritus: A Meta-Analysis

Wang

Chuo

et al. 2021

Toxins

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Uremic pruritus is common among patients with advanced or end-stage renal disease, with an incidence of >40% among patients on dialysis. Uremic clearance granules (UCGs) are effective in managing uremic pruritus and delay the progression of chronic kidney disease. We conducted a systematic review and a meta-analysis to evaluate the efficacy of UCG in patients with uremic pruritus. Several electronic databases were searched systematically from their inceptions until 19 July 2021. Randomized control trials evaluating the efficacy of UCG in patients with uremic pruritus were selected. Eleven trials including 894 participants were published between 2011 and 2021. Patients administered UCGs had a significantly decreased visual analog scale score (mean difference [MD], −2.02; 95% confidence interval [CI], −2.17 to −1.88), serum levels of hsCRP (MD, −2.07 mg/dL; 95% CI, −2.89 to −1.25; p < 0.00001), TNF-α (MD, −15.23 mg/L; 95% CI, −20.00 to −10.47; p < 0.00001]), β2-MG (MD, −10.18 mg/L; 95% CI, −15.43 to −4.93; p < 0.00001), and IL-6 (MD, −6.13 mg/L; 95% CI, −7.42 to −4.84; p < 0.00001). In addition, UCGs significantly reduced serum levels of creatinine, BUN, PTH, iPTH, phosphorus, and the overall effectiveness rate. UCGs could be an attractive complementary therapy for patients with uremic pruritus.

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