–308G&gt;A and –1031T&gt;C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery disease

Ghazouani, Lakhdar; Khalifa, Sonia-Ben-Hadj; Abboud, Nesrine; Addad, Faouzi; Khalfallah, A; Nsiri, Brahim; Mediouni, Mounira; Almawi, Wassim Y.; Mahjoub, Touhami

doi:10.1515/cclm.2009.287

Cited by 18 publications

(7 citation statements)

References 30 publications

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“…Distribution of allele frequency of TNF-α -1031 (T/C) was similar to those reported in a Chinese population at 18.2% (p>0.05) [10]. Conversely, there was significant difference between our population with Korean and Tunisian population at 7.6% and 16.4% respectively (p<0.05) [9], [11]. This suggest the distribution of allelic frequency of TNF-α -1031 (T/C) varies across population due to inter-ethnic differences.…”

Section: Discussionsupporting

confidence: 86%

The Relevance of Genetic Polymorphism of CYP1A1, ICAM-1, TNF-α and INSR Genes in Women with Polycystic Ovary Syndrome (PCOS)

Hazwanie¹,

Gan²,

Nalliah³

2015

JOMB

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Polycystic Ovarian Syndrome (PCOS) is a complex endocrine disorder commonly seen in about 6.5-8% of women of reproductive age. Polygenic trait is common in PCOS and various factors related to the androgenic pathways and the metabolic syndrome have been studied including genes encoding inflammatory cytokines. In this respect we aimed to study the involvement of polymorphisms of four genes; cytochrome P450 1A1 (CYP1A1), intercellular adhesion of molecule (ICAM-1), tumour necrosis factor alpha (TNF-α) and insulin receptor gene (INSR). Twelve women fulfilling the criteria of PCOS and 145 controls were recruited. In this study, TNF-α-1031 (T/C) (rs1799964) is found to be significantly higher in PCOS group compared to healthy controls (OR = 5.044; CI: 2.139-11.899; p-value < 0.05). This suggests TNF-α-1031 (T/C) appears to be a potential candidate as a molecular marker in determining PCOS risk. This study also found a strong association between PCOS and obesity (BMI>25); obesity is a major risk factor of PCOS. Studies of association enables clinicians to have a better understanding of the genetic factors for PCOS especially in a multi-ethnic population such as Malaysia, where robust data addressing PCOS are still lacking.  Index Terms-polycystic ovarian syndrome (PCOS), polymorphism, single nucleotide polymorphisms (SNPs)

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Section: Discussionsupporting

confidence: 86%

The Relevance of Genetic Polymorphism of CYP1A1, ICAM-1, TNF-α and INSR Genes in Women with Polycystic Ovary Syndrome (PCOS)

Hazwanie¹,

Gan²,

Nalliah³

2015

JOMB

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“…The TNF- α –1031C allele frequency was 23.55% in control individuals versus 25.48% in patients with CHD ( P = 0.46), indicating that the −1031C allele is not a risk factor of CHD in our population. This is in accordance with the results of Ghazouani et al who have demonstrated no link between the TNF- α −1031T>C promoter polymorphism and coronary artery disease (CAD) in a Tunisian population [22]. Oda et al have reported that the TNF- α −1031C allele acts as a protective factor in atherosclerotic severity [23].…”

Section: Discussionsupporting

confidence: 90%

Tumor Necrosis Factor‐Alpha Gene Promoter Region Polymorphism and the Risk of Coronary Heart Disease

Asifa

Liaquat

Murtaza

et al. 2013

The Scientific World Journal

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Background. Tumor necrosis factor-alpha (TNF-α) gene polymorphisms have been implicated in the manifestation of atherosclerosis. Controversy exists regarding the link between the cytokine's variant genotype and CHD among different ethnic groups. There have been fewer studies on the TNF-α gene −1031T>C and −863C>A polymorphisms in relation to CHD. Therefore, the current study was designed to investigate the association of the TNF-α gene −1031T>C and −863C>A polymorphisms with CHD in a Pakistani population. Methods. Patients with CHD (n = 310) and healthy individuals (n = 310) were enrolled in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results. A significant difference was observed in the −863C>A polymorphism between patients with CHD and control subjects (P < 0.0001). CHD risk was positively associated with the variant allele −863A (P < 0.0001) in the study subjects. There was no significant link between the −1031T>C polymorphism and CHD risk in the study population. Haplotypes A-T and A-C of the TNF-alpha gene loci at −863 and −1031 showed higher frequency in the patient group compared with controls (P < 0.05). Conclusion. The TNF-α −863C>A gene polymorphism was associated with the pathogenesis of CHD while the −1031T>C polymorphism did not show any link with the disease in a Pakistani population.

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“…[11][12][13][14][15] There is emerging evidence that of an association of TNF-α-308 polymorphism, a G/A transition at -308-bp position, which may alter promoter activity, with TNFα expression in vitro, as well as plasma concentrations. 16 An increased serum concentration of TNFα is an independent predictor of cardiovascular disease 17 and is a marker for recurrent coronary events following a previous acute myocardial infarction. 18 This polymorphism is associated with several conditions, [19][20][21] including infection, asthma, 20 autoimmune disease, 21,22 , and immune-mediated diseases, such as rheumatoid arthritis.…”

Section: Introductionmentioning

confidence: 99%

“…21 However, the data are inconsistent. 16,27,28 Ghazouani et al 16 have reported that the TNF-α 308 (G/A) SNP was not associated with CAD in Tunisian patients. A further study also showed the lack of association of TNF-α 308G/A polymorphism and risk of coronary artery disease and myocardial infarction.…”

mentioning

confidence: 99%

Association of tumor necrosis factor‐α ‐308 G/A gene polymorphism with coronary artery diseases: An evidence‐based study

Kazemi

Jamialahmadi

Avan

et al. 2017

Clinical Laboratory Analysis

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Background Coronary artery disease (CAD) is the leading cause of death worldwide and remains a major health problem, providing the rationale for identification of molecular markers for detection of individuals at high risk of developing CAD. Tumor necrosis factor‐α (TNF‐α) plays a crucial role in the pathogenesis of CAD. We have therefore explored the association of TNF‐α 308 (G/A) gene polymorphism in 903 individuals with/without CAD. Methods TNF‐α 308 gene polymorphism was analyzed in 903 subjects of whom 222 were healthy controls. Among the 681 patients who were investigated angiographically, 468 had ≧50% stenosis and 213 patients had <50% stenosis. Biochemical profiles (eg, triglycerides, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, fasting blood glucose, and CRP) were evaluated. Associations between TNF‐α genotypes with biochemical and anthropometric characteristics were determined. Results The frequencies of TNF‐α‐AA or AG genotypes were significantly lower in patients classified as CAD patients with ≥ or <50% obstruction in at least one coronary artery, compared to the control group. We observed that CAD patients with ≥50% stenosis and with AA genotype were associated with higher risk of CAD with OR of 3.56 (95%CI: 1.02‐12.41; P=.046) using multivariate analysis. Moreover, we found that TNF‐α‐308‐AA genotype was associated with blood pressure and CRP level in CAD patients, compared to the wild type‐genotype. Conclusion Our data showed an association of TNF‐α‐308G/A polymorphism with CAD patients with ≥50% obstruction, supporting the need for further investigations on the role of TNF‐α‐308G/A polymorphism with hypertension.

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–308G>A and –1031T>C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery disease

Cited by 18 publications

References 30 publications

The Relevance of Genetic Polymorphism of CYP1A1, ICAM-1, TNF-α and INSR Genes in Women with Polycystic Ovary Syndrome (PCOS)

The Relevance of Genetic Polymorphism of CYP1A1, ICAM-1, TNF-α and INSR Genes in Women with Polycystic Ovary Syndrome (PCOS)

Tumor Necrosis Factor‐Alpha Gene Promoter Region Polymorphism and the Risk of Coronary Heart Disease

Association of tumor necrosis factor‐α ‐308 G/A gene polymorphism with coronary artery diseases: An evidence‐based study

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