308 TLR3 Activation Increases the Vulnerability of the Neonatal Brain to Hypoxia-Ischemia

Abstract

Abstracts perfusion was measured using laser Doppler. Local cerebral bloodflow was measured by iodo[ 14 C]antipyrine autoradiography. None of the procedures of serial mechanical interruptions of blood flow applied at reperfusion induced a reduction of infarct volume after 72 hours. In contrast to adult ischemia, a gradual perfusion was found during early re-flow both in the left internal carotid artery and in the cortical penumbra. No hyperemia was detected on autoradiograms. In addition, vasodilation to hypercapnia remained unchanged. Absence of acute hyperemia during early CCA re-flows and absence of increased cerebrovascular reactivity could at least in part explain the inefficiency of ischemic postconditioning in the developing brain.