306 Acute lymphoblastic leukemia in children: 5-year experience of a single national pediatric oncology centre

Kranjčec, Izabela; Jakovljević, Gordana; Bubnjar, Katarina

doi:10.1136/archdischild-2021-europaediatrics.306

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“…Leukemia is the most common cancer in children with rapid progression, and early diagnosis is essential 1. One hypothesis is that leukemia results from mutations caused by exposure to carcinogens, including pesticides, during pregnancy or infancy 2…”

Section: Introductionmentioning

confidence: 99%

“…Leukemia is the most common cancer in children with rapid progression, and early diagnosis is essential. 1 One hypothesis is that leukemia results from mutations caused by exposure to carcinogens, including pesticides, during pregnancy or infancy. 2 Pesticides are a critical group of environmental pollutants with the highest use in agriculture, which are widely employed to protect against diseases and pests.…”

Section: Introductionmentioning

confidence: 99%

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Organochlorine Pesticides, Oxidative Stress Biomarkers, and Leukemia: A Case-Control Study

Rafeeinia

Asadikaram

Karimi-Darabi

et al. 2022

Journal of Investigative Medicine

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Exposure to pesticides has been linked to an elevated risk of leukemia. The present research aimed to evaluate the relationship between organochlorine (OC) pesticides and biomarkers of oxidative stress in patients with leukemia. This work was conducted on 109 patients with leukemia and 109 healthy controls. The serum concentrations of seven derivatives of OCs including alpha-hexachlorocyclohexane (HCH), beta-HCH, gamma-HCH, 2,4-dichlorodiphenyltrichloroethane (DDT), 4,4-DDT, 2,4-dichlorodiphenyldichloroethylene (DDE), and 4,4-DDE along with acetylcholinesterase (AChE), glutathione peroxidase (GPx), superoxide dismutase (SOD), paraoxonase-1 (PON1), and catalase (CAT) activities as well as total antioxidant capacity (TAC), nitric oxide (NO), protein carbonyl (PC), and malondialdehyde (MDA) levels were measured in all the subjects. Levels of OCs were remarkably higher in patients with leukemia compared with the controls (p<0.05). In addition, levels of SOD, AChE, GPx, PON1, and TAC were remarkably lower in patients with leukemia compared with controls (p<0.05). In contrast, MDA, NO, and PC concentrations were higher in patients with leukemia than in the controls (p<0.05). Moreover, the serum level of 4,4-DDE was negatively associated with GPx activity (p=0.038). Our findings suggest that OCs may play a role in the development of leukemia by disrupting the oxidant/antioxidant balance.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%