Differences in pulmonary and extra-pulmonary characteristics in severely versus non-severely fatigued recipients of allogeneic hematopoietic stem cell transplantation: a cross-sectional, comparative study

Barğı, Gülşah; Boşnak-Güçlü, Meral; Sucak, Ayhan

doi:10.1080/10245332.2018.1526441

Cited by 7 publications

(6 citation statements)

References 43 publications

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“…7 Ayrıca, Quadriceps femoris kas kuvvetinin yorgunluk ile yakın ilişkili olduğu tespit edilmiştir. 7,24 Bununla paralel olarak, çalışmamızda da daha yüksek yorgunluğa sahip bireylerde daha çok fonksiyonel kayıpların olduğu söylenebilir. Buradan yola çıkarak özellikle allojenik HKHN uygulanan bireylerin yorgunluk, Quadriceps femoris kas kuvveti ve fonksiyonel performans açısında daha fazla etkilenmiş olduğu dolayısıyla daha fazla destekleyici tedavilere ihtiyacı olduğu düşünülmüştür.…”

Section: Discussionunclassified

Investigation of muscle strength, pain, fatigue, and physical activity levels by transplant type in individuals undergoing hematopoietic stem cell transplantation

Kabak

UYSAL

Aladağ

et al. 2021

Journal of Exercise Therapy and Rehabilitation

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Amaç: Çalışmamızın amacı, hematopoietik kök hücre nakli (HKHN) tedavisi uygulanan bireylerde nakil tipine göre kas kuvveti, ağrı, yorgunluk ve fiziksel aktivite düzeyini araştırmaktı. Yöntem: Çalışmamıza HKHN ile tedavi olmuş ve en az 3 ay geçmiş toplam 61 birey dahil edildi. Ağrı ve yorgunluk düzeyi Vizuel Analog Skalası ile değerlendirildi. Katılımcıların kavrama kuvveti ve periferal kas kuvveti skorları dinamometre ile ölçüldü. 30saniye Otur-Kalk Testi fonksiyonel performansı değerlendirmede kullanıldı. Uluslararası Fiziksel Aktivite Anketi, fiziksel aktivite düzeyini ölçmede kullanıldı. Bulgular: Bireyler nakil tipine göre otolog (n=30) ve allojenik (n=31) olarak iki gruba ayrıldı. Katılımcıların tanısı dışında gruplar arasında demografik ve medikal karakteristikler açısından anlamlı bir fark yoktu (p˃0,05). Gruplar arasında kaydedilen sonuç ölçümleri karşılaştırıldığında; allojenik HKHN uygulanan bireylerin otolog HKHN uygulanan bireylere göre anlamlı ölçüde daha yüksek yorgunluğu var iken (p=0,027); Quadriceps femoris kas kuvveti (p=0,042) ve 30-saniye Otur-Kalk Testi sonuçları (p=0,006) anlamlı ölçüde daha düşüktü. Gruplar arasında diğer kaydedilen sonuç ölçümleri açısından anlamlı bir farklılık yoktu (p˃0,05). Sonuç: Allojenik HKHN uygulanan bireyler otolog HKHN uygulanan bireylere göre daha fazla fiziksel problemlere sahiptir. Fizyoterapistler, nakil tipinin hastanın fonksiyonel defisitlerini artırabileceğinin farkında olup egzersiz programlarını nakil tipine göre ayarlayarak kişilerin en erken seviyede toparlanmalarına destek olmalıdırlar. Anahtar Kelimeler: kök hücre nakli, Kas kuvveti, Fiziksel aktivite, Ağrı, Yorgunluk.Investigation of muscle strength, pain, fatigue, and physical activity levels by transplant type in individuals undergoing hematopoietic stem cell transplantationPurpose: The aim of the present study was to investigate muscle strength, pain, fatigue, and physical activity level in terms of transplantation type in individuals undergoing hematopoietic stem cell transplantation (HSCT). Methods: A total of 61 indiviuals treated with HSCT at least 3 months ago were included in this study. Pain and fatigue level was assessed by using the Visual Analogue Scale. Grip strength and peripheral muscle strength of the participants were assessed by using dynamometer. The 30-second Sit to Stand Test was used to assess functional performance. The International Physical Activity Questionnaire was used to measure physical activity level. Results: Individuals were assigned to two groups as autologous (n=30) and allogeneic (n=31) according to the transplantation type. There was no significant difference in terms of demographic and medical characteristics except for diagnosis participants between the groups (p˃0.05). When compared the recorded outcomes between the groups; patients treated with allogenic HSCT had significantly higher fatigue level (p=0.027), while significanly lower quadriceps femoris muscle strength (p=0.042) and the 30-second Sit to Stand test score (p=0.006) than patients treated with au...

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Section: Discussionunclassified

Investigation of muscle strength, pain, fatigue, and physical activity levels by transplant type in individuals undergoing hematopoietic stem cell transplantation

Kabak

UYSAL

Aladağ

et al. 2021

Journal of Exercise Therapy and Rehabilitation

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“…The use of post-HSCT corticosteroids has been shown to be a risk factor for severe fatigue and deterioration of QOL. 21 In addition, severe fatigue may be associated with poorer survival.…”

Section: Fatiguementioning

confidence: 99%

Inpatient Rehabilitation of Hematopoietic Stem Cell Transplant Patients

Fu,

Morishita

2024

Am J Phys Med Rehabil

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Hematopoietic stem cell transplants play an important role in the treatment of cancer, particularly hematologic malignancies. These patients can encounter functional impairments unique to hematopoietic stem cell transplant, including deconditioning, cancer-related fatigue, steroid myopathy, graft versus host disease, and capillary leak syndrome. Medical fragility and increased risk of infection may make rehabilitation challenging on the acute care and postacute care settings. Patients admitted to acute inpatient rehabilitation experience a high rate of transfer to the primary acute service and high rate of mortality after transfer back. Physical medicine and rehabilitation physicians can use a number of strategies to mitigate these patients’ risk of medical complications including evidence-based predictive models to assist with postacute rehabilitation triage, physiatry-led consult-based rehabilitation, and oncology hospitalist comanagement on inpatient rehabilitation.

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“…This transfer usually occurs around day +25 (ranging between 19 and 35 days) after the transplantation. These “early” patients suffer from the same side effects and discomforts as other cancer patients soon after therapy ( Table 2 ), such as fatigue [ 19 ], nausea, vomiting, neurocognitive deficits [ 20 , 21 ], and perhaps diarrhoea. Additional specific problems after alloHCT are discussed below.…”

Section: Acute Rehabilitation As An Inpatientmentioning

confidence: 99%

Rehabilitation after Allogeneic Haematopoietic Stem Cell Transplantation: A Special Challenge

Bertz

2021

Cancers

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The general population is getting older and suffer more haematological malignancies despite being physically fit. These malignancies are mainly only curable via an alloHCT, and they are now carried out more frequently. Patients benefit from intensive rehabilitation earlier and may need it repeatedly in cases of severe side effects (e.g., graft-versus-host disease). They can suffer many problems that other cancer patients do not experience, such as severe infections, continued immunosuppression, nutritional restrictions, acute or chronic GvHD, or organ impairments (e.g., lung, eyes). They may also encounter various associated psychological problems, e.g., feeling like a chimera. Rehabilitation centres willing to care for patients after alloHCT should have an experienced multidisciplinary team and should work in close co-operation with the primary transplant centre.

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Differences in pulmonary and extra-pulmonary characteristics in severely versus non-severely fatigued recipients of allogeneic hematopoietic stem cell transplantation: a cross-sectional, comparative study

Cited by 7 publications

References 43 publications

Investigation of muscle strength, pain, fatigue, and physical activity levels by transplant type in individuals undergoing hematopoietic stem cell transplantation

Investigation of muscle strength, pain, fatigue, and physical activity levels by transplant type in individuals undergoing hematopoietic stem cell transplantation

Inpatient Rehabilitation of Hematopoietic Stem Cell Transplant Patients

Rehabilitation after Allogeneic Haematopoietic Stem Cell Transplantation: A Special Challenge

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