Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study

Krátký, Jan; Ježková, J; Kosák, Mikuláš; Vítková, Hana; Bartáková, Jana; Mráz, Miloš; Lukas, Jindrich; Límanová, Z; Jiskra, Jan

doi:10.1155/2018/9793850

Cited by 16 publications

(15 citation statements)

References 23 publications

(24 reference statements)

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“…This result was in line with the study of Heikkila et al (9) and Anil et al (17) However, the study of Krátký al. (19) showed that HT was found to be higher in papillary cancer compared to benign thyroid nodule. However, a study conducted by Jankovic et al (16) in population-based FNA studies did not find a statistically significant correlation between HT and PTC.…”

Section: Discussionmentioning

confidence: 99%

Hashimoto’s thyroiditis is not a risk factor for thyroid cancer

Eshraghi

Mousavi

2018

Universa Medicina

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Background Thyroid carcinoma is the most common endocrine malignancy. Chronic inflammation can be involved in tumorigenesis. It is estimated that more than 20% of all tumors are caused by persistent inflammatory conditions. The objective of the present study was to compare the inflammatory factor level of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and thyroiditis between benign and malignant thyroid nodules. Methods A cross-sectional study was conducted involving 94 patients (47 patients with benign tumors as controls and 47 patients with malignant tumors as cases). ESR and CRP were measured and analyzed. Mean ESR and CRP in both groups was compared using independent t-test. The chi-square test was used to assess the risk of cancer in patients with Hashimoto’s thyroidits and with significance level at p<0.05. Results The mean age of the patients in the benign group was 42.28 ± 13.43 years and in the malignant group 42.20 ± 16.32 (20-85) years, which was not significantly different (p=0.350). Independent t-test results were not significantly different between mean ESR and CRP in both groups (p=0.800 and p=0.993 respectively). Hashimoto’s thyroiditis was not a risk factor for thyroid cancer (OR=1.58; 95% CI:0.63-4.01). Conclusion This study demonstrated that Hashimoto’s thyroiditis was not a risk factor for thyroid cancer. Factors such as ESR and CRP are acute phase reactants and their levels increase in cases of acute inflammation, but may not increase significantly in chronic inflammatory conditions and malignancies.

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Section: Discussionmentioning

confidence: 99%

Hashimoto’s thyroiditis is not a risk factor for thyroid cancer

Eshraghi

Mousavi

2018

Universa Medicina

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“…Positive antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-Tg) antibodies were associated with TC (anti-TPO 44% in TC vs. 27% in controls, p=0.005, anti-TG 35% in TC group vs. 21% in controls, p=0.018), and the TC group had significantly higher TSH (median 1.88 mIU/L vs. 1.21 mIU/L, p<0.001). Using multiple logistic regression, positive anti-TPO was identified as an independent risk factor (OR 2.21, p=0.018), while spontaneously suppressed TSH<0.5 mIU/L was a protective factor (OR 0.3, p=0.01) against TC [32].…”

Section: Discussionmentioning

confidence: 99%

Papillary thyroid carcinoma in children with Hashimoto’s thyroiditis – a review of the literature between 2000 and 2020

Sur

Gaga

Lazăr

et al. 2020

Journal of Pediatric Endocrinology and Metabolism

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ObjectivesThyroid cancer is the most common pediatric endocrine neoplasm representing 3% of all malignancies in children. Hashimoto’s thyroiditis (HT) is also a common disorder in the pediatric age range. Patients with HT frequently develop enlarged thyroid with nodules. We aimed to provide a literature review on the frequency of papillary thyroid carcinoma (PTC) in patients with HT.ContentA literature search of the PubMed database between 2000 and 2020 was performed, using the relevant keywords “papillary thyroid carcinoma,” “Hashimoto’s thyroiditis” and “children”. We followed the PRISMA statement guidelines during the preparation of this review. Six studies (n=2,065 patients with HT) were retained for the final analysis. The follow-up of the patients with HT was from 2 to 10 years. PTC was diagnosed in 0.67–7.87% of the HT patients included in these studies. In patients with HT and nodules, the percentage of PTC varied between 5.13 and 35%. The overall occurrence of PTC in patients with HT was 3.07%.Summary and OutlookThe number of patients developing thyroid nodules in relation to HT was increased. The development of PTC in children with HT appeared to be higher than in the normal population.

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“…Thirdly, equivocal-favorable versus unfavorable-is the impact of HT on the prognosis of concurrent PTC [39][40][41][42][43][44][45][46][47][48]. Finally, the translation of the serum concentrations of thyroid autoantibodies [49-56] and thyroid-stimulating hormone (TSH) [55, [57][58][59][60][61][62][63] into predictive and prognostic PTC biomarkers incites a perpetual conflict.…”

Section: Rationality In the Investigation Of The Interrelationship Ofmentioning

confidence: 99%

“…In particular, the positivity of TPOAbs [49,52,53], TgAbs [51,53,110], as well as TPOAbs coexistent with TgAbs [52], has been shown to harbor a predictive value. Moreover, the positivity of TPOAbs [52,57] and TgAbs [50-53, 110] has been designated as an independent predictive factor for thyroid malignancy in nodular goiter. Interestingly, the coexistence of TgAbs and TPOAbs is associated with a PTC risk greater than that connected with isolated positivity of either TgAbs or TPOAbs [52].…”

Section: Thyroid Autoantibodies In the Context Of Ht Coexistent With mentioning

confidence: 99%

Papillary Thyroid Carcinoma Intertwined with Hashimoto’s Thyroiditis: An Intriguing Correlation

Deligiorgi¹,

Trafalis²

2019

Knowledges on Thyroid Cancer

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Illustrating the ancient link connecting inflammation with cancer, the correlation of papillary thyroid carcinoma (PTC) with Hashimoto's thyroiditis (HT) has long been pursued as intersection of autoimmunity-induced chronic inflammation and tumor-induced immunity. The dramatic rise of the incidence of PTC οver the last decades-the main culprit for "thyroid cancer (TC) epidemic"-parallels the increasing incidence of HT, potentially reflecting a pathogenetic link that could be harnessed in diagnostics and therapeutics. Prompted by this perspective, in the present chapter, we dissect the hitherto elusive interrelationship of PTC with HT, focusing on four issues: firstly, an unresolved conundrum is whether PTC emerges due to or notwithstanding immune response or mirrors the "tumor defense-induced autoimmunity." Secondly, the interrelationship of HT with PTC may be merely epiphenomenon of selection bias inherent in thyroidectomy series. Thirdly, the impact of HT on coexistent PTC is equivocal-host protective versus tumor protective. Fourthly, translating serum concentrations of thyroid autoantibodies and thyroidstimulating hormone (TSH) into predictive and prognostic PTC biomarkers dichotomizes, till now, the researchers. In the era of precision medicine, illuminating whether HT precipitates PTC or vice versa is awaited with anticipation in order to refine the preventive and therapeutic policy counteracting "TC epidemic."

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Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study

Cited by 16 publications

References 23 publications

Hashimoto’s thyroiditis is not a risk factor for thyroid cancer

Hashimoto’s thyroiditis is not a risk factor for thyroid cancer

Papillary thyroid carcinoma in children with Hashimoto’s thyroiditis – a review of the literature between 2000 and 2020

Papillary Thyroid Carcinoma Intertwined with Hashimoto’s Thyroiditis: An Intriguing Correlation

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