Brevican “nets” voltage-gated calcium channels at the hair cell ribbon synapse

Abstract

During hearing in mammals, “sensorineural” inner hair cells convert sound wave-generated mechanical input into electrical activity, resulting in glutamate release onto type I spiral ganglion neurons (SGNs) at specialized synapses known as “ribbon synapses”. New findings published here in BMC Biology by Sonntag and colleagues indicate a role for the proteoglycan Brevican in forming perineurounal net (PNN) baskets at these synapses and controlling the spatial distribution of presynaptic voltage-gated calcium channels that regulate glutamate release. These findings may provide insight into the mechanism by which individual ribbon synapses within a single hair cell can function in an independent manner to facilitate hearing within a broad dynamic range.

Association Study of CACNA1E Gene Polymorphisms and Sudden Sensorineural Hearing Loss

“…이와 같이 청력과 VGCC와의 연관성을 알아보기 위해 많 은 연구들이 진행되었다. [13][14][15][16][17][18][19][20][21] 내이와 청각 경로 발현에 관여 하는 VGCC 복합체는 주로 Cav1.3 L-형과 Cav2.3 R-형이 관 여한다. 14,15) 그중 Cav1.…”