Effect modification of CPY2E1 and GSTZ1 genetic polymorphisms on associations between prenatal disinfection by-products exposure and birth outcomes

Zhou, Bin; Pan, Yang; Gong, Yajie; Zeng, Qiang; Lu, Wen-Qing; Miao, Xiaoping

doi:10.1016/j.envpol.2018.09.083

Cited by 15 publications

(6 citation statements)

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“…However, it is a protective factor for bladder cancer in Asian populations [ 45 ] and patients with lung cancer or drug-related liver damage [ 25 , 35 ]. A study reported that the T allele is related to lower birth weight of newborns whose maternal disinfection by-products are exposed during gestation [ 34 ]. In this study, we demonstrated that the T allele of the C-1054T SNP is a genetic risk factor for GDM in the Chinese population.…”

Section: Discussionmentioning

confidence: 99%

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CYP2E1 C-1054T and 96-bp I/D genetic variations and risk of gestational diabetes mellitus in chinese women: a case-control study

Liu

et al. 2023

BMC Pregnancy Childbirth

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Background Cytochrome P450 2E1 (CYP2E1) plays a key role in the metabolism of xenobiotic and endogenous low-molecular-weight compounds. This study aimed to determine if the genetic variations of 96-bp insertion/deletion (I/D) and C-1054T (rs2031920) in CYP2E1 were associated with the risk of gestational diabetes mellitus (GDM). Methods CYP2E1 polymorphisms were genotyped in a case-control study of 1,134 women with uncomplicated pregnancies and 723 women with GDM. The effects of genotype on the clinical, metabolic, and oxidative stress indices were assessed. Results The CYP2E1 C-1054T variant was associated with an increased risk of GDM based on the genotype, recessive, dominant, and allele genetic models (P < 0.05). The TT + CT genotype remained a significant predictive factor for GDM risk after correcting for maternal age and pre-pregnancy body mass index (OR = 1.277, 95% CI: 1.042–1.563, P = 0.018). Moreover, fasting insulin concentrations and homeostatic model assessment of insulin resistance were significantly higher in GDM patients carrying the T allele than in those with the CC genotype (P < 0.05). Furthermore, the combined genotype II + ID/TT + CT of the 96-bp I/D and C-1054T polymorphisms further increased the risk of GDM when the combined genotype DD/CC was set as the reference category (OR = 1.676, 95% CI: 1.182–2.376, P = 0.004). Conclusions The T allele of the C-1054T polymorphism and its combination with the I allele of the 96-bp I/D variation in CYP2E1 are associated with an increased risk of GDM in the Chinese population. The − 1054T allele may be associated with more serious insulin resistance in patients.

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Section: Discussionmentioning

confidence: 99%

“…There is almost a complete link disequilibrium between the 96-bp I/D and C-1054T variations (D′ = 0.94) [ 32 ]. Notably, these two polymorphisms are associated with the occurrence of some cancers [ 31 – 33 ], adverse birth outcomes [ 34 ], polycystic ovary syndrome (PCOS) [ 27 ], and drug-induced liver injury [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

CYP2E1 C-1054T and 96-bp I/D genetic variations and risk of gestational diabetes mellitus in chinese women: a case-control study

Liu

et al. 2023

BMC Pregnancy Childbirth

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“…On the other hand, the THMs are highly volatile and therefore ingestion, inhalation, and dermal exposure could be equally important routes of exposure (Backer et al 2000;Xu et al 2002), indicating that nonconsumers of tap water are also exposed to the THMs. Some studies have tried to reduce the misclassification by collecting information on water consumption and on showering/bathing habits (Danileviciute et al 2012;Grazuleviciene et al 2013), and others measured the blood concentrations of THMs (Smith et al 2016;Zhou et al 2018). However, because THMs are easily absorbed and have a short half-life, the blood concentrations fluctuate, with high peaks of the most volatile CBPs seen shortly after showering, complicating the use of biomarkers of exposure (Backer et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Exposure to Drinking Water Chlorination by-Products and Fetal Growth and Prematurity: A Nationwide Register-Based Prospective Study

Säve‐Söderbergh

Toljander

Donat‐Vargas

et al. 2020

Environ Health Perspect

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BACKGROUND: Chlorination is globally used to produce of safe drinking water. Chlorination by-products are easily formed, and there are indications that these are associated with adverse reproductive outcomes. OBJECTIVES: We conducted a nationwide register-based prospective study to assess whether gestational exposure to the four most common chlorination by-products [total trihalomethanes (TTHMs)] via tap water was associated with risk of small for gestational age (SGA), preterm delivery, and very preterm delivery. To date, this is one of the largest studies assessing drinking water TTHM-associated adverse reproductive outcomes. METHODS: We included all singleton births 2005-2015 (live and stillbirths) of mothers residing in Swedish localities having >10,000 inhabitants, ≤2 operating waterworks, adequate information on chlorination treatment, and a sufficient number of routine TTHM measurements in tap water. Individual maternal second and third trimester exposure was obtained by linking TTHM measurements to residential history, categorized into no chlorination, <5, 5-15, and >15 lg TTHM/L. Outcomes and covariates were obtained via the linkage to Swedish health and administrative registers. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression using inverse probability weighting. We stratified the analyses by chlorination treatment (chloramine, hypochlorite). RESULTS: Based on approximately 500,000 births, we observed a TTHM dose-dependent association with increased risk of SGA, confined to treatment with hypochlorite, corresponding to a multivariable-adjusted OR = 1.20 (95% CI: 1.08, 1.33) comparing drinking water TTHM >15 lg to the unexposed. Similar results were obtained when, instead of unexposed, the lowest exposure category (<5 lg=L TTHM) was used as reference. No clear associations were observed for preterm delivery and very preterm delivery. DISCUSSION: Chlorination by-products exposure via drinking water was associated with increased risk of SGA in areas with hypochlorite treatment.

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“…The study designs varied across the selected studies, as they included case-control studies [ 19 – 39 ], birth cohort studies [ 40 – 71 ], nested case-control studies [ 72 – 77 ], cross-sectional studies [ 78 – 83 ], collaborations of birth cohort studies [ 84 – 86 ], and a case study [ 87 ]. The types of environmental and lifestyle-related chemicals assessed were diverse.…”

Section: Gene-environment Interaction Studiesmentioning

confidence: 99%

“…Three studies examined the biomarker levels related to maternal smoking including cotinine levels [ 47 , 49 , 51 ]. Thirty-eight other studies observed the outcomes of chemical exposure during pregnancy (also see Supplementary Tables 1 to 5 ), including exposure to particulate matter (PM) of 2.5 microns or less in diameter (PM 2.5 ) [ 65 ], PM of 10 microns or less in diameter (PM 10 ) [ 66 ], household air pollution (HAP) [ 67 ], air quality index (AQI) [ 77 ], benzo(a)pyrene [ 43 ], nitrogen oxides (NO x ) [ 57 – 59 ], acrylamides [ 45 ], caffeine [ 28 , 63 ], metals [ 42 , 48 , 53 , 54 , 75 , 81 ], soluble mica [ 35 ], pesticides [ 22 , 32 , 44 ], perfluorinated compounds [ 52 ], dioxins [ 41 , 50 ], disinfection by-products [ 21 , 26 , 29 , 69 , 71 , 72 , 76 ], parabens [ 64 ], phenols [ 55 ], alcohol [ 19 , 24 ], floriculture work [ 30 ], phthalates [ 37 ], and folates [ 81 ]. This present study especially focuses on exposure to smoking during pregnancy.…”

Section: Gene-environment Interaction Studiesmentioning

confidence: 99%

Gene-environment interactions related to maternal exposure to environmental and lifestyle-related chemicals during pregnancy and the resulting adverse fetal growth: a review

Kobayashi

Sata

Kishi

2022

Environ Health Prev Med

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Background There are only limited numbers of reviews on the association of maternal-child genetic polymorphisms and environmental and lifestyle-related chemical exposure during pregnancy with adverse fetal growth. Thus, this article aims to review: (1) the effect of associations between the above highlighted factors on adverse fetal growth and (2) recent birth cohort studies regarding environmental health risks. Methods Based on a search of the PubMed database through August 2021, 68 epidemiological studies on gene-environment interactions, focusing on the association between environmental and lifestyle-related chemical exposure and adverse fetal growth was identified. Moreover, we also reviewed recent worldwide birth cohort studies regarding environmental health risks. Results Thirty studies examined gene-smoking associations with adverse fetal growth. Sixteen maternal genes significantly modified the association between maternal smoking and adverse fetal growth. Two genes significantly related with this association were detected in infants. Moreover, the maternal genes that significantly interacted with maternal smoking during pregnancy were cytochrome P450 1A1 ( CYP1A1 ), X-ray repair cross-complementing protein 3 ( XRCC3 ), interleukin 6 ( IL6 ), interleukin 1 beta ( IL1B ), human leukocyte antigen (HLA) DQ alpha 1 ( HLA-DQA1 ), HLA DQ beta 1 ( HLA-DQB1 ), and nicotinic acetylcholine receptor. Fetal genes that had significant interactions with maternal smoking during pregnancy were glutathione S-transferase theta 1 ( GSTT1 ) and fat mass and obesity-associated protein ( FTO ). Thirty-eight studies examined the association between chemical exposures and adverse fetal growth. In 62 of the 68 epidemiological studies (91.2%), a significant association was found with adverse fetal growth. Across the studies, there was a wide variation in the analytical methods used, especially with respect to the genetic polymorphisms of interest, environmental and lifestyle-related chemicals examined, and the study design used to estimate the gene-environment interactions. It was also found that a consistently increasing number of European and worldwide large-scale birth cohort studies on environmental health risks have been conducted since approximately 1996. Conclusion There is some evidence to suggest the importance of gene-environment interactions on adverse fetal growth. The current knowledge on gene-environment interactions will help guide future studies on the combined effects of maternal-child genetic polymorphisms and exposure to environmental and lifestyle-related chemicals during pregnancy. Supplementary information The online version contains supplementary material available ...

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Effect modification of CPY2E1 and GSTZ1 genetic polymorphisms on associations between prenatal disinfection by-products exposure and birth outcomes

Cited by 15 publications

References 46 publications

CYP2E1 C-1054T and 96-bp I/D genetic variations and risk of gestational diabetes mellitus in chinese women: a case-control study

CYP2E1 C-1054T and 96-bp I/D genetic variations and risk of gestational diabetes mellitus in chinese women: a case-control study

Exposure to Drinking Water Chlorination by-Products and Fetal Growth and Prematurity: A Nationwide Register-Based Prospective Study

Gene-environment interactions related to maternal exposure to environmental and lifestyle-related chemicals during pregnancy and the resulting adverse fetal growth: a review

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