Endoscopic small-capacity forceps increase the pathological diagnosis of gastric indefinite neoplasia

Background and Aim Gastrointestinal endoscopy and biopsy‐based pathological findings are needed to diagnose early gastric cancer. However, the information of biopsy specimen is limited because of the topical procedure; therefore, pathology doctors sometimes diagnose as gastric indefinite for dysplasia (GIN). Methods We compared the accuracy of physician‐performed endoscopy (trainee, n = 3; specialists, n = 3), artificial intelligence (AI)‐based endoscopy, and/or molecular markers (DNA methylation: BARHL2, MINT31, TET1, miR‐148a, miR‐124a‐3, NKX6‐1; mutations: TP53; and microsatellite instability) in diagnosing GIN lesions. We enrolled 24,388 patients who underwent endoscopy, and 71 patients were diagnosed with GIN lesions. Thirty‐two cases of endoscopic submucosal dissection (ESD) in 71 GIN lesions and 32 endoscopically resected tissues were assessed by endoscopists, AI, and molecular markers to identify benign or malignant lesions. Results The board‐certified endoscopic physicians group showed the highest accuracy in the receiver operative characteristic curve (area under the curve [AUC]: 0.931), followed by a combination of AI and miR148a DNA methylation (AUC: 0.825), and finally trainee endoscopists (AUC: 0.588). Conclusion AI with miR148s DNA methylation‐based diagnosis is a potential modality for diagnosing GIN.

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Combination of artificial intelligence‐based endoscopy and miR148a methylation for gastric indefinite dysplasia diagnosis

Watanabe

Oikawa

Agawa

et al. 2021

Clinical Laboratory Analysis

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Endoscopic small-capacity forceps increase the pathological diagnosis of gastric indefinite neoplasia

Abstract: Because the SmF use may increase the rate of GIN diagnosis, the use of SmF with a standard-caliber endoscope should be avoided.

Cited by 1 publication

References 10 publications

Combination of artificial intelligence‐based endoscopy and miR148a methylation for gastric indefinite dysplasia diagnosis

Combination of artificial intelligence‐based endoscopy and miR148a methylation for gastric indefinite dysplasia diagnosis

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