MIR4532 gene variant rs60432575 influences the expression of KCNJ11 and the sulfonylureas-stimulated insulin secretion

Chen, Zhangren; He, Fazhong; Liu, Mou-Ze; Hu, Jin-Lei; Xu, Heng; Zhou, Hong‐Hao; Zhang, Wei

doi:10.1007/s12020-018-1754-6

Cited by 4 publications

(1 citation statement)

References 33 publications

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“… 90 A study found that expression of KCNJ11 was influenced by rs60432575 G > A of MIR4532 , hence causing reduction in sulfonylureas-mediated insulin secretion. 91 …”

Section: Role Of Epigeneticsmentioning

confidence: 99%

Determinants in Tailoring Antidiabetic Therapies: A Personalized Approach

Rizvi¹,

Al-Abbas²,

Verma³

et al. 2022

Glob Med Genet

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Diabetes has become a pandemic as the number of diabetic people continues to rise globally. Being a heterogeneous disease, it has different manifestations and associated complications in different individuals like diabetic nephropathy, neuropathy, retinopathy, and others. With the advent of science and technology, this era desperately requires increasing the pace of embracing precision medicine and tailoring of drug treatment based on the genetic composition of individuals. It has been previously established that response to antidiabetic drugs, like biguanides, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide 1 (GLP-1) agonists, and others, depending on variations in their transporter genes, metabolizing genes, genes involved in their action, etc. Responsiveness of these drugs also relies on epigenetic factors, including histone modifications, miRNAs, and DNA methylation, as well as environmental factors and the lifestyle of an individual. For precision medicine to make its way into clinical procedures and come into execution, all these factors must be reckoned with. This review provides an insight into several factors oscillating around the idea of precision medicine in type-2 diabetes mellitus.

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“… 90 A study found that expression of KCNJ11 was influenced by rs60432575 G > A of MIR4532 , hence causing reduction in sulfonylureas-mediated insulin secretion. 91 …”

Section: Role Of Epigeneticsmentioning

confidence: 99%