Effect of A Very Low-Calorie Ketogenic Diet on Food and Alcohol Cravings, Physical and Sexual Activity, Sleep Disturbances, and Quality of Life in Obese Patients

Abstract

Psychological well-being and hunger and food control are two relevant factors involved in the success of weight-loss therapy in treating obesity. Thus, this study aims to evaluate food and alcohol cravings, physical and sexual activity, sleep, and life quality (QoL) in obese patients following a very low-calorie ketogenic (VLCK) diet, as well as the role of weight lost and ketosis on these parameters. A battery of psychological test was performed in twenty obese patients (12 females, 47.2 ± 10.2 year and BMI of 35.5 ± 4.4) through the course of a 4-month VLCK diet on four subsequent visits: baseline, maximum ketosis, reduced ketosis, and endpoint. Each subject acted as their own control. Relevantly, the dietary-induced changes in body composition (7.7 units of BMI lost, 18 kg of fat mass (1.2 kg of visceral fat mass)) were associated with a statistically significant improvement in food craving scores, physical activity, sleepiness, and female sexual function. Overall, these results also translated in a notable enhancement in QoL of the treated obese patients. Therefore, the rapid and sustained weight and fat mass (FM) loss induced by the VLCK diet is associated with good food control and improvements in the psychological well-being parameters in obese subjects, which could contribute to the long-term success of this therapy.

Prevalência de comportamentos de risco para transtornos alimentares e uso de dieta “low-carb” em estudantes universitários

“…Os desejos intensos por comida e pensamentos por comida são comuns durante os períodos de dietas 35 . Porém, recentemente foi demonstrado que a LC promoveu redução dos desejos intensos por comida no tratamento de obesidade durante quatro meses 17 , entretanto nossos resultados indicam que a prática não supervisionada está associada com alterações no comportamento alimentar.…”

“…A LC consiste, em termos gerais, em uma baixa proporção de carboidratos, que pode variar de 30 a 130 g de carboidratos por dia, em alguns casos sem restrições de calorias, gordura e proteínas 15 . Porém, alguns estudos a modificaram utilizando diversas abordagens, como visto na LC mediterrânea 16 e na very LC diet/ketogenic 17 . No Brasil, foi proposta recentemente a quantidade de 80 g de carboidratos ao dia sem restrições lipídica e proteica.…”

Keto microbiota: A powerful contributor to host disease recovery

“…KD have shown to affect both, microbiota and several hormones levels [13,62]. Although to date, results about importance of gender on ketotherapeutic effects are controversial [63][64][65], due to the interplay between diet-microbiotahormones, the sex and hormonal status of an individual may influence on the efficacy of keto treatments. Reinforcing this, KD has become as a promising treatment in those diseases where sex hormones profile is altered such as ovarian or endometrial cancer [51], obesity [65] or polycystic ovarian syndrome [51].…”

Research Trend Analysis of Questionnaires for Evaluation of Weight Loss Effect on Health-Related Quality of Life

“…정신적 건강(mental health) 항목의 경우 체중 감량 후 변화하지 않았다고 보고한 연구와 14,17) , 증가 하였다고 보고한 연구가 있었다 19) . [22][23][24] . 또한, 감소된 체중이 클수 록 IWQOL-Lite 점수가 증가하였는데 22,23) , 특히 Kolotkin [37][38][39] .…”

“…No subscale EQ-5D (+) 20,29,32,34,35) NR Obesity-specific IWQOL-Lite (+) [22][23][24]29,[31][32][33][34] Physical function 22,23,32,34) , self-esteem 22,31,32,34) , sexuallife 22,23,32,34) , publicdistress 22,23,32,34) , work I get discouraged when I try to lose weight…”