In-Site Monocyte Implantation in Bone Grafting for Maxillary Atrophy Reconstruction

Deo, Vito Del; Fico, Antonio; Marini, Corrado P.; Senese, Salvatore; Gasparini, Giulio

doi:10.1097/id.0000000000000813

Cited by 2 publications

(3 citation statements)

References 33 publications

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“…Nevertheless, the underlying mechanism is not fully understood due to its complex biochemical factors. The appropriate amount of mononuclear macrophages is very important for bone remodeling and regeneration, which should not be overactivated, while their activity should not be completely inhibited either . The Nap-Alen/HAP composite hydrogel constructed in this study met these requirements and inhibited the osteolytic differentiation and proliferation of overactivated BMDMs.…”

Section: Results and Discussionmentioning

confidence: 85%

“…The appropriate amount of mononuclear macrophages is very important for bone remodeling and regeneration, which should not be overactivated, while their activity should not be completely inhibited either. 37 The Nap-Alen/HAP composite hydrogel constructed in this study met these requirements and inhibited the osteolytic differentiation and proliferation of overactivated BMDMs. However, the two hydrogel groups still included some mature osteoclasts, some active BMDMs, and a moderate degree of osteoclastic differentiation, which meant that the creation of osteoclasts was not entirely inhibited and the necessary local bone remodeling was preserved.…”

Section: Nap Alen/hap Inhibits the Biological Function Of Bmdmsmentioning

confidence: 71%

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Bisphosphonate-Modified Functional Supramolecular Hydrogel Promotes Periodontal Bone Regeneration by Osteoclast Inhibition

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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Regeneration of periodontal tissue remains a challenge. Under periodontitis, osteoclasts are overactivated and bone loss occurs. We incorporated sodium alendronate (Alen), a medication commonly used to treat osteoporosis, into a supramolecular hydrogel system in order to create a novel biomaterial that would promote periodontal bone regeneration by inhibiting osteoclast overactivation. The Nap-Gly-Phe-Phe (NapGFF) peptide chain was modified to synthesize the functional Nap-Alen gelator. Afterward, the Nap-Alen/HAP supramolecular hydrogel composite with a suitable hydroxyapatite (HAP) ratio was constructed, which has outstanding mechanical properties and 3D structure. In addition to its good biocompatibility, it can inhibit the proliferation of bone marrow-derived macrophages (BMDMs) and differentiation of osteoclasts. Due to the simultaneous introduction of porous HAP, the hydrogel with a nanofiber structure was formed into a 3D mesh-like sparse porous composite hydrogel. While enhancing the mechanical properties of the gel, the porous structure facilitated the attachment and migration of bone regeneration-related cells. Therefore, it can effectively promote the regeneration of periodontal bone. In the future, by modifying the biophysical properties and loading stem cells or cytokines, this supramolecular hydrogel composite constructed in this study may provide a new strategy for tissue regeneration engineering and provide a preliminary experimental basis for relevant clinical translational studies.

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Section: Results and Discussionmentioning

confidence: 85%

Section: Nap Alen/hap Inhibits the Biological Function Of Bmdmsmentioning

confidence: 71%

Bisphosphonate-Modified Functional Supramolecular Hydrogel Promotes Periodontal Bone Regeneration by Osteoclast Inhibition

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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“…Therefore, researchers have proposed a method to combine other repair materials or related factors, including complex bone morphogenetic protein, autologous bone marrow, and growth factors, which have become a hot spot in the research of heterogeneous bone. On the premise of avoiding immune rejection, it strengthens the ability of bone induction and promotes bone healing (Del Deo et al, 2018;Li et al, 2018). With the development of related research and technology, compound xenotransplantation will receive more and more attention.…”

Section: Xenogeneic Bonementioning

confidence: 99%

Recent Trends in the Development of Bone Regenerative Biomaterials

Tang

Liu

et al. 2021

Front. Cell Dev. Biol.

114

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The goal of a biomaterial is to support the bone tissue regeneration process at the defect site and eventually degrade in situ and get replaced with the newly generated bone tissue. Biomaterials that enhance bone regeneration have a wealth of potential clinical applications from the treatment of non-union fractures to spinal fusion. The use of bone regenerative biomaterials from bioceramics and polymeric components to support bone cell and tissue growth is a longstanding area of interest. Recently, various forms of bone repair materials such as hydrogel, nanofiber scaffolds, and 3D printing composite scaffolds are emerging. Current challenges include the engineering of biomaterials that can match both the mechanical and biological context of bone tissue matrix and support the vascularization of large tissue constructs. Biomaterials with new levels of biofunctionality that attempt to recreate nanoscale topographical, biofactor, and gene delivery cues from the extracellular environment are emerging as interesting candidate bone regenerative biomaterials. This review has been sculptured around a case-by-case basis of current research that is being undertaken in the field of bone regeneration engineering. We will highlight the current progress in the development of physicochemical properties and applications of bone defect repair materials and their perspectives in bone regeneration.

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In-Site Monocyte Implantation in Bone Grafting for Maxillary Atrophy Reconstruction

Cited by 2 publications

References 33 publications

Bisphosphonate-Modified Functional Supramolecular Hydrogel Promotes Periodontal Bone Regeneration by Osteoclast Inhibition

Bisphosphonate-Modified Functional Supramolecular Hydrogel Promotes Periodontal Bone Regeneration by Osteoclast Inhibition

Recent Trends in the Development of Bone Regenerative Biomaterials

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