Combination of magnetic resonance imaging and targeted contrast agent for the diagnosis of myocardial infarction

Jiang-jun, Qin; Zhou, Shuai; Li, Zhiwei; Chen, Yinan; Qin, Qian; Ai, Tao

doi:10.3892/etm.2018.6600

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…38 • Chitosan/SPIO-enclosed albumin nanoparticles. 39 • Improving the resolution of fluorescence imaging.…”

Section: Global Contrast Enhancementmentioning

confidence: 99%

“…38 Chitosan/Fe 3 O 4 -enclosed albumin nanoparticles provide higher signal intensity in the infarcted myocardium, which may allow detection of a similar pathological hallmark following stroke. 39 Blood-brain barrier integrity is an important consideration in stroke, both from the point of view of drug delivery (see later sections) and as an element of the risk of hemorrhagic transformation after thrombolysis. BBB integrity can be assessed noninvasively using MRI after intravenous administration of contrast agents such as Gadolinium-diethylene triamine penta-acetic acid (Gd-DTPA, one of the most commonly used non-nanotech contrast agents).…”

Section: Nanoparticles In Stroke Imaging and Diagnosticsmentioning

confidence: 99%

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Applications of Nanotechnology in the Diagnosis and Therapy of Stroke

Landowski

Niego

Sutherland

et al. 2019

Semin Thromb Hemost

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Stroke is a leading cause of death and disability worldwide. The classification of stroke subtypes is difficult but critical for the prediction of clinical course and patient management, and limited treatment options are available. There is an urgent need for improvements in both diagnosis and therapy. Strokes have rapidly evolving phases of damage involving unique compartments of the brain, which imposes severe limitations for current diagnostic and treatment procedures. The rapid development of nanotechnology in other areas of modern medicine has ignited a widespread interest in its potential for the field of stroke. An important feature of nanoparticles is the relative ease in which their structures and surface chemistries can be modified for specific and potentially multiple, simultaneous purposes. Nanoparticles can be synthesized to carry and deliver therapeutics to specific cellular or subcellular compartments; they can be engineered to provide enhanced contrast for imaging based on the detection of changes in the blood flow; or possess ligand-specific chemistries which can facilitate diagnosis and monitor the treatment response. More specifically for a stroke, nanoparticles can be engineered to release their payload in response to the distinct extracellular processes occurring around the clot and in the ischemic penumbra, as well as aid in the detection of pathological hallmarks present at various stages of stroke progression. These capacities allow targeted release of disease-modifying agents in the affected brain tissue, increasing treatment efficacy, and limiting unwanted side effects. While nanospheres, liposomes, and mesoporous nanostructures all emerge as future prospects for stroke treatment and diagnosis, much of this potential is yet to be clinically realized. This review outlines aspects of nanotechnology identified as having potential to revolutionize the field of stroke.

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“…38 • Chitosan/SPIO-enclosed albumin nanoparticles. 39 • Improving the resolution of fluorescence imaging.…”

Section: Global Contrast Enhancementmentioning

confidence: 99%

Section: Nanoparticles In Stroke Imaging and Diagnosticsmentioning

confidence: 99%

Applications of Nanotechnology in the Diagnosis and Therapy of Stroke

Landowski

Niego

Sutherland

et al. 2019

Semin Thromb Hemost

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5-Azacytidine incorporated chitosan/collagen/gold nanoparticle matrix preparation and characterization with potential to repair myocardial infarction

Nikitha Shalom,

Narayan,

Sangamithra

et al. 2023

emergent mater.

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Cell type-targeting nanoparticles in treating central nervous system diseases: Challenges and hopes

Guo,

2023

Nanotechnology Reviews

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Effective and safe pharmacotherapies for central nervous system (CNS) disorders remain a major obstacle to human health worldwide. Nanotechnology offers promise in addressing this challenge by enabling the transport of large molecules across the blood–brain barrier (BBB) and the delivery of multiple drugs. Numerous studies have demonstrated the efficacy of nanodrugs in animal models of various CNS disorders, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, stroke, lysosomal storage disease, and gliomas. Nanoparticles (NPs), tailor-made to enhance drug enrichment locally and promote extended drug release, can prevent neuronal death, decrease neurotoxicity, and inhibit tumor growth. In addition to drug delivery, gene therapy using nanotechnology has emerged as a potentially curative option for neurodegenerative diseases. In this review, we summarize how NPs have successfully crossed the BBB and specifically targeted different cells in various CNS disease models over the past decade. Although nanotechnology holds great promise, several drawbacks and challenges must be addressed before its effective implementation in the treatment of CNS diseases.

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Combination of magnetic resonance imaging and targeted contrast agent for the diagnosis of myocardial infarction

Cited by 3 publications

References 30 publications

Applications of Nanotechnology in the Diagnosis and Therapy of Stroke

Applications of Nanotechnology in the Diagnosis and Therapy of Stroke

5-Azacytidine incorporated chitosan/collagen/gold nanoparticle matrix preparation and characterization with potential to repair myocardial infarction

Cell type-targeting nanoparticles in treating central nervous system diseases: Challenges and hopes

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