Hyperoside protects the blood-brain barrier from neurotoxicity of amyloid beta 1–42

Liu, Chenyang; Bai, Kuan Jen; Liu, Xiaohui; Li-mi, Zhang; Yu, Guran

doi:10.4103/1673-5374.239445

Cited by 25 publications

(5 citation statements)

References 34 publications

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“…The condensation of chromatin and cytoplasmic content of affected neurons makes them appear smaller than the surrounding cells with a small darkly stained pyknotic nucleus with acidophilic cytoplasm. These results are in accordance with previous studies (Zhao et al 2016 ; Liu et al 2018 ; Su et al 2020 ).…”

Section: Discussionsupporting

confidence: 94%

Pentoxifylline as Add-On Treatment to Donepezil in Copper Sulphate-Induced Alzheimer’s Disease-Like Neurodegeneration in Rats

Elseweidy,

Mahrous,

Ali

et al. 2023

Neurotox Res

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Alzheimer’s disease (AD), the most common neurodegenerative disorder, is characterized by behavioral, cognitive, and progressive memory impairments. Extensive neuronal loss, extracellular accumulation of insoluble senile amyloid-β (Aβ) plaques, and intracellular neurofibrillary tangles (NFTs) are the major pathological features. The present study aimed to investigate the therapeutic effect of donepezil (DON) and pentoxifylline (PTX) in combination to combat the neurodegenerative disorders (experimental AD) induced by CuSO4 intake in experimental rats. Thirty adult male Wistar rats (140–160 g) were used in this study. AD was first induced in rats by CuSO4 supplement to drinking water (10 mg/L) for 14 weeks. The AD group received no further treatment. Oral treatment with DON (10 mg/kg/day), PTX (100 mg/kg/day), or DON + PTX for the other three groups was started from the 10th week of CuSO4 intake for 4 weeks. Cortex markers like acetylcholine (ACh), acetylcholinesterase (AChE), total antioxidant capacity (TAC), and malondialdehyde (MDA) and hippocampus markers like β-amyloid precursor protein cleaving enzyme 1 (BACE1), phosphorylated Tau (p-tau), Clusterin (CLU), tumor necrosis factor-α (TNF-α), caspase-9 (CAS-9), Bax, and Bcl-2 were measured. The histopathology studies were done by using hematoxylin and eosin and Congo red stains as well as immunohistochemistry for neurofilament. CuSO4 induced adverse histological and biochemical changes. The histological injury in the hippocampus was inhibited following the administration of the DON and PTX. The brain tissue levels of AChE, MDA, BACE1, p-tau, CLU, CAS-9, Bax, and TNF-α were significantly increased, while brain tissue levels of ACh, TAC, and Bcl-2 were significantly decreased in CuSO4-treated rats as compared with the untreated control group. The effects induced by either DON or PTX on most studied parameters were comparable. Combined treatment of DON and PTX induced remarkable results compared with their individual use. However, more clinical and preclinical studies are still required to further confirm and prove the long-term efficacy of such combination.

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Section: Discussionsupporting

confidence: 94%

Pentoxifylline as Add-On Treatment to Donepezil in Copper Sulphate-Induced Alzheimer’s Disease-Like Neurodegeneration in Rats

Elseweidy,

Mahrous,

Ali

et al. 2023

Neurotox Res

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“…These can act on post-translational modification and degradation of TJ proteins via 3 major processes: cytotoxic effects such as Aβ-induced Ca 2 + -calcineurin signaling; inflammation involving a spectrum of mediators including MMP (matrix metalloproteinase) that degrade both extracellular matrix and TJs, cytokines (eg, IL-1β, IL-6, TNF-α, IL-12, IL-23), chemokines (eg, CCL2, CCL4, CCL3, CCL7, CXCL10), complement components (eg, C1q, C3), and adhesion molecules (eg, ICAM, P-selectin, E-selectin) that drive intrinsic signaling in BECs and in concert drive leukocyte (eg, GM-CSF [granulocyte-macrophage colony-stimulating factor]), microglial and perivascular macrophage (eg, colony stimulating factor) migration and activation into perivascular space; as well as mitochondrial impairment and increased reactive oxygen species (eg, NADPH [nicotinamide adenine dinucleotide phosphate] oxidase-2) that contribute to the endothelial Aβ toxicity and BEC inflammatory responses involved in TJ remodeling. 16,45,46 Altered TJ protein expression in Aβ-affected BECs can also occur at the transcriptional level through downregulation of transcriptional factor KLF2 (Kruppel-like factor 2) and serum response factor/myocardin related transcription factor A (SRF-MRTF-A) activity. Reduced TJ protein expression creates a "defective and vulnerable" brain endothelial barrier.…”

Section: Bbb In Ad Ad-vasculopathy and Inherited Forms Of Caamentioning

confidence: 99%

Blood-Brain Barrier Dysfunction in Normal Aging and Neurodegeneration: Mechanisms, Impact, and Treatments

Andjelkovic

Situ

Citalán-Madrid

et al. 2023

Stroke

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Cerebral endothelial cells and their linking tight junctions form a unique, dynamic and multi-functional interface, the blood-brain barrier (BBB). The endothelium is regulated by perivascular cells and components forming the neurovascular unit. This review examines BBB and neurovascular unit changes in normal aging and in neurodegenerative disorders, particularly focusing on Alzheimer disease, cerebral amyloid angiopathy and vascular dementia. Increasing evidence indicates BBB dysfunction contributes to neurodegeneration. Mechanisms underlying BBB dysfunction are outlined (endothelium and neurovascular unit mediated) as is the BBB as a therapeutic target including increasing the uptake of systemically delivered therapeutics across the BBB, enhancing clearance of potential neurotoxic compounds via the BBB, and preventing BBB dysfunction. Finally, a need for novel biomarkers of BBB dysfunction is addressed.

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“…(Yeongsil): RT 6.55 min, 465.10 m/z, hyperoside; RT 6.65 min, 479.08 m/z, Miquelianin; RT 7.86 min, 611.16 m/z, multinoside A; and RT 10.23 min, 653.17 m/z, multinoside A acetate. Hyperoside protects BBB [33,34], and multinoside A and multinoside A acetate require biological research. In particular, Miquelianin was previously reported as being able to pass the BBB [35,36].…”

Section: Discussionmentioning

confidence: 99%

A Combination of Rosa Multiflora and Zizyphus Jujuba Enhance Sleep Quality in Anesthesia-Induced Mice

Eom

Lee

et al. 2022

IJMS

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Sleep is an essential component of quality of life. The majority of people experience sleep problems that impact their quality of life. Melatonin is currently a representative sleep aid. However, it is classified as a prescription drug in most countries, and consumers cannot purchase it to improve their sleep. This sleep induction experiment in mice aimed to identify a natural combination product (NCP) that can create synergistic sleep-promoting effects. Based on the mechanism of action of sleep, we investigated whether phenomenological indicators of sleep quality change according to the intake of NCP. The sleep onset and sleep time of the mice that consumed the NCP found by this study were improved compared to the existing sleep aids. The mean melatonin level in the blood increased by 197% compared to the control. To our knowledge, this is the first study to demonstrate that Rosa multiflora Thunb. (Yeongsil) can promote sleep similarly to Zizyphus jujuba Miller (Sanjoin). The results indicate a preclinical study of NCPs containing Rosa multiflora Thunb and Zizyphus jujuba Miller developed by us showed significant differences in sleep incubation and duration depending on melatonin concentrations. Our results also suggest that increased melatonin concentrations in the blood are likely to improve sleep quality, especially regarding incubation periods.

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Hyperoside protects the blood-brain barrier from neurotoxicity of amyloid beta 1–42

Cited by 25 publications

References 34 publications

Pentoxifylline as Add-On Treatment to Donepezil in Copper Sulphate-Induced Alzheimer’s Disease-Like Neurodegeneration in Rats

Pentoxifylline as Add-On Treatment to Donepezil in Copper Sulphate-Induced Alzheimer’s Disease-Like Neurodegeneration in Rats

Blood-Brain Barrier Dysfunction in Normal Aging and Neurodegeneration: Mechanisms, Impact, and Treatments

A Combination of Rosa Multiflora and Zizyphus Jujuba Enhance Sleep Quality in Anesthesia-Induced Mice

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