Abstract:Background: Hydrogen-oxygen mixture (H2-O2) may reduce airway resistance in patients with acute severe tracheal stenosis, yet data supporting the clinical use of H2-O2 are insufficient. Objectives: To evaluate the efficacy and safety of breathing H2-O2 in acute severe tracheal stenosis. Methods: Thirty-five consecutive patients with severe acute tracheal stenosis were recruited in this prospective self-control study. Air, H2-O2… Show more
“…Previous researches have demonstrated 67% H 2 and 33% O 2 mixture gas strikingly decreased ROS induced by ischemia-reperfusion in the brain [34, 50], liver [51], and heart [52] in animal models. Clinical studies have reported 67% H 2 and 33% O 2 mixture reduced the inspiratory effort in patients with acute severe tracheal stenosis [53] and restored the exhausted supply of CD8+ T cells in patients with advanced colorectal cancer [54]. Our results showed 67% H 2 and 33% O 2 mixture gas increased T-SOD and GSH activity and decreased MDA content against the elevated ROS level induced by CIH.…”
Obstructive sleep apnea (OSA) can cause intermittent changes in blood oxygen saturation, resulting in the generation of many reactive oxygen species (ROS). To discover new antioxidants and clarify the endoplasmic reticulum (ER) stress involved in cardiac injury in OSA, we established a chronic intermittent hypoxia (CIH) rat model with a fraction of inspired O2 (FiO2) ranging from 21% to 9%, 20 times/h for 8 h/day, and the rats were treated with H2-O2 mixture (67% hydrogen and 33% oxygen) for 2 h/day for 35 days. Our results showed that H2-O2 mixture remarkably improved cardiac dysfunction and myocardial fibrosis. We found that H2-O2 mixture inhalation declined ER stress-induced apoptosis via three major response pathways: PERK-eIF2α-ATF4, IRE 1-XBP1, and ATF 6. Furthermore, we revealed that H2-O2 mixture blocked c-Jun N-terminal kinase- (JNK-) MAPK activation, increased the ratio of Bcl-2/Bax, and inhibited caspase 3 cleavage to protect against CIH-induced cardiac apoptosis. In addition, H2-O2 mixture considerably decreased ROS levels via upregulating superoxide dismutase (SOD) and glutathione (GSH) as well as downregulating NADPH oxidase (NOX 2) expression in the hearts of CIH rats. All the results demonstrated that H2-O2 mixture significantly reduced ER stress and apoptosis and that H2 might be an efficient antioxidant against the oxidative stress injury induced by CIH.
“…Previous researches have demonstrated 67% H 2 and 33% O 2 mixture gas strikingly decreased ROS induced by ischemia-reperfusion in the brain [34, 50], liver [51], and heart [52] in animal models. Clinical studies have reported 67% H 2 and 33% O 2 mixture reduced the inspiratory effort in patients with acute severe tracheal stenosis [53] and restored the exhausted supply of CD8+ T cells in patients with advanced colorectal cancer [54]. Our results showed 67% H 2 and 33% O 2 mixture gas increased T-SOD and GSH activity and decreased MDA content against the elevated ROS level induced by CIH.…”
Obstructive sleep apnea (OSA) can cause intermittent changes in blood oxygen saturation, resulting in the generation of many reactive oxygen species (ROS). To discover new antioxidants and clarify the endoplasmic reticulum (ER) stress involved in cardiac injury in OSA, we established a chronic intermittent hypoxia (CIH) rat model with a fraction of inspired O2 (FiO2) ranging from 21% to 9%, 20 times/h for 8 h/day, and the rats were treated with H2-O2 mixture (67% hydrogen and 33% oxygen) for 2 h/day for 35 days. Our results showed that H2-O2 mixture remarkably improved cardiac dysfunction and myocardial fibrosis. We found that H2-O2 mixture inhalation declined ER stress-induced apoptosis via three major response pathways: PERK-eIF2α-ATF4, IRE 1-XBP1, and ATF 6. Furthermore, we revealed that H2-O2 mixture blocked c-Jun N-terminal kinase- (JNK-) MAPK activation, increased the ratio of Bcl-2/Bax, and inhibited caspase 3 cleavage to protect against CIH-induced cardiac apoptosis. In addition, H2-O2 mixture considerably decreased ROS levels via upregulating superoxide dismutase (SOD) and glutathione (GSH) as well as downregulating NADPH oxidase (NOX 2) expression in the hearts of CIH rats. All the results demonstrated that H2-O2 mixture significantly reduced ER stress and apoptosis and that H2 might be an efficient antioxidant against the oxidative stress injury induced by CIH.
“…Furthermore, breathing H 2 -O 2 might reduce the inspiratory effort in patients with acute severe tracheal stenosis and can be used safely for this purpose (Zhou et al, 2019). Although H 2 gas is flammable, concentrations < 4%, together with oxygen at room temperature, are incombustible.…”
Section: Safety Of Hydrogenmentioning
confidence: 99%
“…Clinical research has shown that hydrogen dissolved in irrigation solution reduces corneal endothelial damage during phacoemulsification ( Igarashi et al, 2019 ). Furthermore, breathing H 2 -O 2 might reduce the inspiratory effort in patients with acute severe tracheal stenosis and can be used safely for this purpose ( Zhou et al, 2019 ). Although H 2 gas is flammable, concentrations < 4%, together with oxygen at room temperature, are incombustible.…”
Hydrogen has been shown to have antioxidant, anti-inflammatory, hormone-regulating, and apoptosis-resistance properties, among others. Based on a review of the research, the use of hydrogen might reduce the destructive cytokine storm and lung injury caused by SARS-CoV-2 during COVID-19 (Corona Virus Disease 2019) in the early stage, stimulating ropy sputum drainage, and ultimately reducing the incidence of severe disease. Molecular hydrogen treatment has the potential to become a new adjuvant therapy for COVID-19, but its efficacy and safety require large clinical trials and further confirmation.
“…Patients with COVID-19 have been characterized by increasingly laborious breathing as a result of greater airway resistance. Due to smaller molecular weight, helium-oxygen mixed gas has been applied to ameliorate dyspnea in patients with respiratory failure [102] and chronic obstructive pulmonary disease [103] . However, due to the low cost-effectiveness ratio, helium–oxygen mixed gas has not been extensively adopted in clinical practice.…”
Section: Advances In Clinical Managementmentioning
Coronavirus disease 2019 (COVID-19)—the third in a series of coronavirus infections—has caused a global public health event in the 21st century, resulting in substantial global morbidity and mortality. Building on its legacy of managing severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), China has played a key role in the scientific community by revealing the viral transmission routes and clinical characteristics of COVID-19 and developing novel therapeutic interventions and vaccines. Despite these rapid scientific and technological advances, uncertainties remain in tracing the original sources of infection, determining the routes of transmission and pathogenesis, and addressing the lack of targeted clinical management of COVID-19. Here, we summarize the major COVID-19 research advances in China in order to provide useful information for global pandemic control.
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