Treatment of trauma related anger in operation enduring freedom, operation Iraqi freedom, and operation New Dawn veterans: Rationale and study protocol

Shea, M. Tracie; Lambert, Jennifer; Reddy, Madhavi K.; Presseau, Candice; Sevin, Elizabeth; Stout, Robert L.

doi:10.1016/j.conctc.2018.08.011

Cited by 4 publications

(4 citation statements)

References 33 publications

(34 reference statements)

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“…Anger and aggression problems are frequently reported in veterans after military deployment (Elbogen et al 2013;Reijnen et al 2015;Shea et al 2018). In a sample of 1090 USA military veterans, 9% endorsed engaging in severe violence and 26% in other physical aggression in the previous year of the study (Elbogen et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Regions of white matter abnormalities in the arcuate fasciculus in veterans with anger and aggression problems

et al. 2019

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Aggression after military deployment is a common occurrence in veterans. Neurobiological research has shown that aggression is associated with a dysfunction in a network connecting brain regions implicated in threat processing and emotion regulation. However, aggression may also be related to deficits in networks underlying communication and social cognition. The uncinate and arcuate fasciculi are integral to these networks, thus studying potential abnormalities in these white matter connections can further our understanding of anger and aggression problems in military veterans. Here, we use diffusion tensor imaging tractography to investigate white matter microstructural properties of the uncinate fasciculus and the arcuate fasciculus in veterans with and without anger and aggression problems. A control tract, the parahippocampal cingulum was also included in the analyses. More specifically, fractional anisotropy (FA) estimates are derived along the trajectory from all fiber pathways and compared between both groups. No between-group FA differences are observed for the uncinate fasciculus and the cingulum, however parts of the arcuate fasciculus show a significantly lower FA in the group of veterans with aggression and anger problems. Our data suggest that abnormalities in arcuate fasciculus white matter connectivity that are related to self-regulation may play an important role in the etiology of anger and aggression in military veterans.

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Section: Introductionmentioning

confidence: 99%

Regions of white matter abnormalities in the arcuate fasciculus in veterans with anger and aggression problems

et al. 2019

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“…For instance, anger signals a dominant status in social settings (Tiedens, 2001), and is often reported by elite athletes during competitive sporting events, where it facilitates optimal athletic performance (Lane, Beedie, Jones, Uphill, & Devonport, 2012;Maxwell & Visek, 2009;Robazza, Bertollo, & Bortoli, 2006;Uphill & Jones, 2007;Woodman et al, 2009). Combat veterans often report anger on the battlefield as a positive, protective force facilitating their personal survival (Adler, Brossart, & Toblin, 2017;Adler, Wright, Bliese, Eckford, & Hoge, 2008;Shea et al, 2018). For women in situations of domestic abuse, anger motivates decisions and ability to leave their abusers, a step typically accompanied by increased risk of personal harm (Choi, Belyea, Phillips, Insel, & Min, 2009).…”

Section: A Neurobehavioral Model Of Agentic Angermentioning

confidence: 99%

Anger, agency, risk and action: A neurobehavioral model with proof-of-concept in healthy young adults

White¹

2022

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Anger can engender action by individuals and groups. It is thus important to understand anger behavioral phenotypes and their underlying neural substrates. Here we introduce a novel neurobehavioral construct that we term agentic anger, a state that motivates action to achieve risky goals, and test predictions of the model in two proof-of-concept studies. In study 1 we used the Incentive Balloon Analogue Risk Task to evaluate subjective states of: a) negative activation (NA) to assess agentic anger in response to frustrative non-reward, and b) positive activation (PA) to assess exuberance to achieved reward in 39 healthy young adult volunteers. Task-induced NA correlated with task-induced PA (r=0.56, p<.001), risk-taking on the task (r=0.27 to 0.36, p≤.05, .01) and trait Social Potency (SP, r=0.34 to 0.35, p<.05), a measure of reward sensitivity on the Multidimensional Personality Questionnaire Brief-Form. Study 2 evaluated within-subject functional MRI response to incentives in 10 males receiving 20 mg d-amphetamine or placebo (total 20 scans), providing data on ventral striatal reactivity to stepped incentives during catecholamine activation. Trait SP (r=+.60, p=.03) and task-induced PA (r=+.72, p=.02) strongly predicted amphetamine-facilitated BOLD response in the right nucleus accumbens, a region involved in action selection. Task-induced NA exhibited large effects with trait SP (r=0.51; d=1.2) and induced PA (r=0.68; d=1.9), replicating Study 1. These findings inform the phenomenology and neurobiology of agentic anger, a state that facilitates voluntary approach toward rewards that entail risk. Neural mechanisms of anger, exuberance and risk-taking in healthy individuals are discussed, with implications for action, decision-making, social justice and behavior change.

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“…For instance, anger signals a dominant status in social settings ( Tiedens, 2001 ), and is reported by elite athletes during competitive sporting events, where it facilitates optimal athletic performance ( Robazza et al, 2006 ; Uphill and Jones, 2007 ; Maxwell and Visek, 2009 ; Woodman et al, 2009 ; Lane et al, 2012 ). Combat veterans report anger on the battlefield as a protective, positive force that facilitates their personal survival ( Adler et al, 2008 , 2017 ; Shea et al, 2018 ). For women in situations of domestic abuse, anger motivates decisions and ability to leave their abusers, a step typically accompanied by an increased risk of personal harm ( Choi et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Anger, agency, risk and action: a neurobehavioral model with proof-of-concept in healthy young adults

et al. 2023

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IntroductionAnger can engender action by individuals and groups. It is thus important to understand anger’s behavioral phenotypes and their underlying neural substrates. Here, we introduce a construct we term agentic anger, a negatively valenced internal state that motivates action to achieve risky goals. We evaluate our neurobehavioral model via testable hypotheses in two proof-of-concept studies.Study 1 MethodsStudy 1 used the Incentive Balloon Analogue Risk Task in a within-subjects, repeated measures design in 39 healthy volunteers to evaluate: (a) impact of blockade of reward on agentic anger, assessed by self-reports of negative activation (NA), (b) impact of achievement of reward on exuberance, assessed by self-reports of positive activation (PA), (c) the interrelationship of these valenced states, and (d) their relationship with personality.Study 1 ResultsTask-induced NA was positively correlated with task-induced PA, risk-taking on the task and trait Social Potency (SP), a measure of trait agency and reward sensitivity on the Multidimensional Personality Questionnaire Brief-Form.Study 2 MethodsStudy 2 assessed functional MRI response to stakes for risk-taking in healthy volunteers receiving 20 mg d-amphetamine in a double-blinded, placebo-controlled crossover design (N = 10 males), providing preliminary information on ventral striatal response to risky rewards during catecholamine activation.Study 2 ResultsTrait SP and task-induced PA were strongly positively related to catecholamine-facilitated BOLD response in the right nucleus accumbens, a brain region where DA prediction error signal shapes action value and selection. Participants’ task-induced NA was strongly positively related with trait SP and task-induced PA, replicating the findings of Study 1.DiscussionTogether these results inform the phenomenology and neurobiology of agentic anger, which recruits incentive motivational circuitry and motivates personal action in response to goals that entail risk (defined as exposure to uncertainty, obstacles, potential harm, loss and/or financial, emotional, bodily, or moral peril). Neural mechanisms of agency, anger, exuberance, and risk-taking are discussed, with implications for personal and group action, decision-making, social justice, and behavior change.

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Treatment of trauma related anger in operation enduring freedom, operation Iraqi freedom, and operation New Dawn veterans: Rationale and study protocol

Cited by 4 publications

References 33 publications

Regions of white matter abnormalities in the arcuate fasciculus in veterans with anger and aggression problems

Regions of white matter abnormalities in the arcuate fasciculus in veterans with anger and aggression problems

Anger, agency, risk and action: A neurobehavioral model with proof-of-concept in healthy young adults

Anger, agency, risk and action: a neurobehavioral model with proof-of-concept in healthy young adults

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