A Universal Influenza Virus Vaccine Candidate Tested in a Pig Vaccination-Infection Model in the Presence of Maternal Antibodies

Sunwoo, Sun Young; Schotsaert, Michael; Morozov, Igor; Davis, Anne Sally; Li, Yuhao; Lee, Jinhwa; McDowell, Chester; Meade, Philip; Nachbagauer, Raffael; García‐Sastre, Adolfo; Ma, Wenjun; Krammer, Florian; Richt, Jüergen A.

doi:10.3390/vaccines6030064

Cited by 14 publications

(18 citation statements)

References 68 publications

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“…VAERD could be reversed when the NA was matched in the vaccine and challenge strain (57) or dampened when M2 protein was administered in conjunction with the respective WIV (58) suggesting that there is an interplay between antibodies targeting different components of the virus. However, the etiology of VAERD remains controversial as a recent paper showed that induction of VAERD by immunization with an adjuvanted H1N2 vaccine, followed by challenge with pandemic H1N1, did not correlate with the presence of anti-stalk antibodies (59).…”

Section: Antibody Mediated Protection Against Swiav Infectionmentioning

confidence: 99%

T and B Cell Immune Responses to Influenza Viruses in Pigs

et al. 2019

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Influenza viruses are an ongoing threat to humans and are endemic in pigs, causing considerable economic losses to farmers. Pigs are also a source of new viruses potentially capable of initiating human pandemics. Many tools including monoclonal antibodies, recombinant cytokines and chemokines, gene probes, tetramers, and inbred pigs allow refined analysis of immune responses against influenza. Recent advances in understanding of the pig innate system indicate that it shares many features with that of humans, although there is a larger gamma delta component. The fine specificity and mechanisms of cross-protective T cell immunity have yet to be fully defined, although it is clear that the local immune response is important. The repertoire of pig antibody response to influenza has not been thoroughly explored. Here we review current understanding of adaptive immune responses against influenza in pigs and the use of the pig as a model to study human disease.

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Section: Antibody Mediated Protection Against Swiav Infectionmentioning

confidence: 99%

T and B Cell Immune Responses to Influenza Viruses in Pigs

et al. 2019

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“…At the same time, many experiments redirecting the immune response to the conserved part of HA by modulation of the immunization protocols were described (Hai et al, 2012;Krammer and Palese, 2014;Sunwoo et al, 2018). Multiple immunizations with chi-meric molecules composed of the stem of one HA subtype and a globular part of different subtypes redirected the antibody response to the repeatedly presented conserved HA2-stem.…”

Section: Strategies Of the Development Of New Ha2-based Anti-influenzmentioning

confidence: 99%

“…Currently, two types of influenza vaccines containing IAV of H1 and H3 subtypes and one or two influenza B virus antigens are approved in human medicine. These are live attenuated vaccines, permitted only in USA and Russia, or inactivated vaccines Sunwoo et al, 2018). The most commonly used inactivated vaccines are split virus vaccines and subunit vaccines containing purified surface glycoproteins of virus (Stropkovská et al, 2010;Soema et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Universal anti-influenza vaccines based on viral HA2 and M2e antigens

Kostolanský¹,

Tomčíková²,

Briestenská³

et al. 2020

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Aquatic birds are the main reservoir of influenza A viruses (IAVs). These viruses can infect humans repeatedly and cause acute respiratory disease with potential of spread in the form of epidemics. In addition, avian influenza viruses that overcome the interspecies barrier and adapt to humans can cause a worldwide pandemic with severe consequences to human health. Therefore, scientists are focused on the development of a "universal" vaccine with a broad protective efficacy, i.e. against different subtypes of influenza A viruses and not only against the currently co-circulating human epidemic strains. Nowadays, several new vaccine design strategies have been described. Most of them utilize the conserved stem part of influenza surface glycoprotein hemagglutinin (HA) or the ectodomain of M2 (M2e) protein with proton-channel activity. A comparison of the effectivity of novel vaccines and their protective mechanisms against influenza infection is discussed in this review and should be considered for the construction of the most effective broadly protective vaccine with minimal side effects. This is the essential goal in influenza virus research today, especially when the infection with new human coronavirus SARS-CoV-2 can interfere with the course of influenza virus infection.

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“…In addition to antibodies, other bioactive molecules are found in breast milk, including cytokines and human milk oligosaccharides (HMOs) that have been shown to inhibit viral entry into cells [189][190][191]. Furthermore, cells are transferred to the infant via breastfeeding, which could play a role in shaping the neonatal and infant microbiome [192].…”

Section: A Key Role For Maternal Vaccination In Protecting Young Infamentioning

confidence: 99%

The Importance of Vaccinating Children and Pregnant Women against Influenza Virus Infection

Misra

Nayak

2019

Pathogens

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Influenza virus infection is responsible for significant morbidity and mortality in the pediatric and pregnant women populations, with deaths frequently caused by severe influenza-associated lower respiratory tract infection and acute respiratory distress syndrome (ARDS). An appropriate immune response requires controlling the viral infection through activation of antiviral defenses, which involves cells of the lung and immune system. High levels of viral infection or high levels of inflammation in the lower airways can contribute to ARDS. Pregnant women and young children, especially those born prematurely, may develop serious complications if infected with influenza virus. Vaccination against influenza will lead to lower infection rates and fewer complications, even if the vaccine is poorly matched to circulating viral strains, with maternal vaccination offering infants protection via antibody transmission through the placenta and breast milk. Despite the health benefits of the influenza vaccine, vaccination rates around the world remain well below targets. Trust in the use of vaccines among the public must be restored in order to increase vaccination rates and decrease the public health burden of influenza.

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A Universal Influenza Virus Vaccine Candidate Tested in a Pig Vaccination-Infection Model in the Presence of Maternal Antibodies

Cited by 14 publications

References 68 publications

T and B Cell Immune Responses to Influenza Viruses in Pigs

T and B Cell Immune Responses to Influenza Viruses in Pigs

Universal anti-influenza vaccines based on viral HA2 and M2e antigens

The Importance of Vaccinating Children and Pregnant Women against Influenza Virus Infection

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