Prenatal maternal psychopathology and stress and offspring HPA axis function at 6 years

Molenaar, Nina M.; Tiemeier, Henning; Rossum, Elisabeth F.C. van; Hillegers, Manon H. J.; Bockting, Claudi; Hoogendijk, Witte J.G.; Akker, E.L. van den; Berg, Mijke P. Lambregtse–van den; Marroun, Hanan El

doi:10.1016/j.psyneuen.2018.09.003

Cited by 47 publications

(32 citation statements)

References 63 publications

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“…25,26 Maternal HPA axis functioning and its influence on the foetus Altered HPA axis activity in mothers who suffer from severe psychiatric disorders can influence the foetus through intrauterine programming of the HPA axis. 19,27 There is some evidence that these early alterations in HPA axis functioning contribute to vulnerability to psychiatric disease in offspring later in life, 28 by early fine-tuning of the HPA axis set point.…”

Section: Hpa Axis and Psychiatric Disordersmentioning

confidence: 99%

An exploratory study of perinatal hair cortisol concentrations in mother–infant dyads with severe psychiatric disorders versus healthy controls

et al. 2021

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Background Maternal psychopathology during pregnancy is associated with negative outcomes in offspring. Increased placental transfer of maternal cortisol may contribute to mediate this association. Hair cortisol concentrations (HCCs) appear to be a good biomarker of long-term prenatal stress exposure. Little is known about the associations between severe maternal psychopathology and perinatal infant HCCs. Aims We assessed HCCs in the perinatal period in mother–infant dyads with and without severe psychiatric disorders. Method We examined group differences in HCCs of mother–infant dyads (n = 18) subjected to severe maternal psychiatric disorders versus healthy control dyads (n = 27). We assessed the correlation of HCCs between mother and infant within both groups, and the association between current maternal symptoms and HCCs in patient dyads. Results Median (interquartile range) and distribution of HCC differed in patients compared with control mothers (U = 468.5, P = 0.03). HCCs in infants of patients did not differ from control infants (U = 250.0, P = 0.67). Subsequently, we found that HCCs within healthy control dyads were correlated (n = 27, r 0.55 (0.14), P = 0.003), but were not within patient dyads (n = 18, r 0.082 (0.13), P = 0.746). HCCs in infants of patients showed a positive correlation with maternal symptoms (n = 16, r = 0.63 (0.06), P = 0.008). Conclusions These preliminary findings suggest that infant HCC reflect perinatal stress exposure. In infants, these early differences could influence lifetime hypothalamic–pituitary–adrenal axis functioning, which might be associated with increased susceptibility to later disease.

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Section: Hpa Axis and Psychiatric Disordersmentioning

confidence: 99%

An exploratory study of perinatal hair cortisol concentrations in mother–infant dyads with severe psychiatric disorders versus healthy controls

et al. 2021

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“…A similar sex-dependent association between prenatal maternal cortisol and newborn telomere length has also been reported recently (Enlow et al, 2019). Studies of self-reported maternal prenatal stress have also shown sex-specific associations, for example, in a publication from the Generation R cohort (n = 2546) mothers’ prenatal stress assessed as life events and long-standing difficulties predicted increased hair cortisol levels at age 5 years in girls but not boys (Molenaar et al, 2019). In a study with both self-reported and objective stress measurement, following mothers pregnant during the Iowa floods (n = 94), maternal prenatal stress was associated with increased cortisol reactivity in girls but not boys at age 2.5 years (Ping et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Sex-dependent associations between maternal prenatal cortisol and child callous-unemotional traits: Findings from the Wirral Child Health and Development Study

Wright

Pickles

Braithwaite

et al. 2019

Psychoneuroendocrinology

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“…The detailed processes are as follows (see, e.g., Molenaar et al, 2019;Bock et al, 2015). When pregnant mothers experience unexpected adverse events or a stressful environment, the hypothalamus (the H of HPA) in the brain area release excessively a type of hormone called corticotropin-releasing hormone (CRH).…”

Section: Stress and Cognitive Deficiencymentioning

confidence: 99%

“…There are also other mediation pathways to explain the association, but the one with HPA axis is commonly accepted.2 Various biological literature tries to find biomarkers to quantify the activity of the HPA axis and the prenatal stress, such as hair cortisone levels (see, e.g.,Molenaar et al, 2019) and dehydroepiandrosterone (DHEA) and dehydroepiandrosteronesulfate (DHEAS) (see, e.g.,Schmelter et al, 2019).…”

mentioning

confidence: 99%

Early Life Adversities and Well-being Later in Life: Evidence from China

Wang¹

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Once I was 23 years old, I fell in love with Econometrics and had a dream to become an econometrician/economist. Then I made a decision to start my training at the University of Groningen. Most of the time, the training was enjoyable because I could feel that I was making progress everyday. Nevertheless, it was also a tough journey. I had once doubted my goal I was pursuing and the meaning of my life. Luckily, when I felt low, there were many people cheering me up and encouraging me to move on. First of all, I want to express my great gratitude to my supervisors Rob Alessie and Viola Angelini. We have had a lot of formal meetings and lunch talks about my curriculum studies, research projects, job seeking, and so on. They are very knowledgeable in both theoretical and empirical economics. I have gained a lot of research experience under their supervision. They always encourage me to think outside the box, ask critical questions to develop my data and economic intuition, and guide me to be a good economist. They are also wonderful people personally. They both care about my work-life balance and help me relax when I experience stressful moments. When I visited the job market, they provided a lot of support and encouragement. Rob inspires me with his insights into many economic and Lastly, I want to thank my family, who always stand by me throughout this journey. Especially, I want to thank my girlfriend Ya for her company. It is my greatest luck to be your boyfriend. We had a lot of wonderful memories together in the past several years, and I am looking forward to having more with you in the future. Last but not least, my gratitude goes to my mother, Rongmei Li, who is the best person in my world and the best reason I live in this world. Her altruistic and dedicated investment in my human capital is the major determinant of all the achievements I have made.

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Prenatal maternal psychopathology and stress and offspring HPA axis function at 6 years

Cited by 47 publications

References 63 publications

An exploratory study of perinatal hair cortisol concentrations in mother–infant dyads with severe psychiatric disorders versus healthy controls

An exploratory study of perinatal hair cortisol concentrations in mother–infant dyads with severe psychiatric disorders versus healthy controls

Sex-dependent associations between maternal prenatal cortisol and child callous-unemotional traits: Findings from the Wirral Child Health and Development Study

Early Life Adversities and Well-being Later in Life: Evidence from China

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