Epithelial membrane protein 2: a novel biomarker for circulating tumor cell recovery in breast cancer

Chen, Q.; Yao, Lanlin; Burner, Danielle; Minev, Boris; Lu, Lingeng; Wang, M.; Ma, Wenxue

doi:10.1007/s12094-018-1941-1

Cited by 13 publications

(6 citation statements)

References 33 publications

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“…Also, the anti-EMP2 monoclonal antibody captured over 80% of the total MDA-MB231 cells. EMP2 might be a more efficient biomarker for capturing CTC in breast cancer blood samples and is worthy of further assessments in clinical trials [ 100 ].…”

Section: Biological Functions Of the Pmp22 Protein Familymentioning

confidence: 99%

Unraveling the structures, functions and mechanisms of epithelial membrane protein family in human cancers

et al. 2022

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Peripheral myelin protein 22 (PMP22) and epithelial membrane proteins (EMP-1, -2, and -3) belong to a small hydrophobic membrane protein subfamily, with four transmembrane structures. PMP22 and EMPs are widely expressed in various tissues and play important roles in cell growth, differentiation, programmed cell death, and metastasis. PMP22 presents its highest expression in the peripheral nerve and participates in normal physiological and pathological processes of the peripheral nervous system. The progress of molecular genetics has shown that the genetic changes of the PMP22 gene, including duplication, deletion, and point mutation, are behind various hereditary peripheral neuropathies. EMPs have different expression patterns in diverse tissues and are closely related to the risk of malignant tumor progression. In this review, we focus on the four members in this protein family which are related to disease pathogenesis and discuss gene mutations and post-translational modification of them. Further research into the interactions between structural alterations and function of PMP22 and EMPs will help understand their normal physiological function and role in diseases and might contribute to developing novel therapeutic tools.

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Section: Biological Functions Of the Pmp22 Protein Familymentioning

confidence: 99%

Unraveling the structures, functions and mechanisms of epithelial membrane protein family in human cancers

et al. 2022

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“…In addition, the functions and potential mechanism of EMP2 are varied in different type of cancers. Recently, Chen et al reported that EMP2 is highly expressed in circulating breast cancer cells 38. And the elevated EMP2 expression is associated with poor prognosis of glioma patients 39.…”

Section: Discussionmentioning

confidence: 99%

EMP2 acts as a suppressor of melanoma and is negatively regulated by mTOR-mediated autophagy

Wang

Zhang³

et al. 2019

J. Cancer

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Cutaneous melanoma is one of the most common malignant skin tumors and advanced melanoma is usually associated with a poor prognosis. In the current study, we demonstrated the tumor suppressing role of epithelial membrane protein-2 (EMP2) by inducing apoptosis in a A375 human melanoma cell line. Mechanistically, the low expression of EMP2 in melanoma is partially due to autophagic protein degradation mediated by the mTOR pathway. These results suggest there is regulation of autophagy as well as EMP2 levels might be an interesting novel targeted therapeutic strategy for melanoma. Although the further investigation is needed to deeply understand the regulatory mechanisms of EMP2 in melanoma progression and metastasis, our results clarify the functions and mechanisms of autophagy in melanoma, and shed new light on novel targeted therapeutics for melanoma.

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“…The level of EMP2 protein is positively associated with cancer progression, which is supported by findings that EMP2 is expressed in 67% of lymph node metastases and is linked with lymphovascular invasion [90]. Recently, EMP2 protein seems to have been identified as a novel biomarker to effectively capture circulating tumor cells (CTCs) in blood samples from patients with breast cancer [93]. In addition, CTCs are more effectively detected in the samples from the pulmonary vein than the peripheral vein, even in the early stage of the cancer [94].…”

Section: Involvement Of Emps In Cancer Metastasismentioning

confidence: 97%

The Pivotal Roles of the Epithelial Membrane Protein Family in Cancer Invasiveness and Metastasis

Amin

Shimizu

Ogita

2019

Cancers

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The members of the family of epithelial membrane proteins (EMPs), EMP1, EMP2, and EMP3, possess four putative transmembrane domain structures and are composed of approximately 160 amino acid residues. EMPs are encoded by the growth arrest-specific 3 (GAS3)/peripheral myelin protein 22 kDa (PMP22) gene family. The GAS3/PMP22 family members play roles in cell migration, growth, and differentiation. Evidence indicates an association of these molecules with cancer progression and metastasis. Each EMP has pro- and anti-metastatic functions that are likely involved in the complex mechanisms of cancer progression. We have recently demonstrated that the upregulation of EMP1 expression facilitates cancer cell migration and invasion through the activation of a small GTPase, Rac1. The inoculation of prostate cancer cells overexpressing EMP1 into nude mice leads to metastasis to the lymph nodes and lungs, indicating that EMP1 contributes to metastasis. Pro-metastatic properties of EMP2 and EMP3 have also been proposed. Thus, targeting EMPs may provide new insights into their clinical utility. Here, we highlight the important aspects of EMPs in cancer biology, particularly invasiveness and metastasis, and describe recent therapeutic approaches.

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Epithelial membrane protein 2: a novel biomarker for circulating tumor cell recovery in breast cancer

Abstract: EMP2 is superior to EpCAM for capturing both MCF7 and MDA-MB-231 cells. Additionally, EMP2 is a novel biomarker and capable of capturing breast cancer cells in patient blood samples.

Cited by 13 publications

References 33 publications

Unraveling the structures, functions and mechanisms of epithelial membrane protein family in human cancers

Unraveling the structures, functions and mechanisms of epithelial membrane protein family in human cancers

EMP2 acts as a suppressor of melanoma and is negatively regulated by mTOR-mediated autophagy

The Pivotal Roles of the Epithelial Membrane Protein Family in Cancer Invasiveness and Metastasis

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