O2-3-Aminopropyl diazeniumdiolates suppress the progression of highly metastatic triple-negative breast cancer by inhibition of microvesicle formation via nitric oxide-based epigenetic regulation

Kang, Fenghua; Zhu, Jiayi; Wu, Jianbing; Lv, Tian; Xiang, Hua; Tian, Jide; Zhang, Yihua; Huang, Zhangjian

doi:10.1039/c8sc00167g

Cited by 22 publications

(12 citation statements)

References 26 publications

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“…An additional study found that knockdown of Rab22a inhibits Bc metastasis in vivo (15). Kang et al (16) designed and synthesized O(2)-3-Aminopropyl diazeniumdiolates 3a-f, which prevents the growth and metastasis of triple negative Bc in vivo as well as in vitro by MHc-I impairing microvesicle formation by altering the expression of miR-203/Rab22a in a nitric oxide-dependent manner.…”

Section: Rab22a Is a Novel Prognostic Marker For Cell Progression In mentioning

confidence: 99%

“…Although much of the research indicates that the Rab22a gene can function as an oncogene in several cancer models and indicates its potential therapy target (15,16), whether Rab22a may be developed as a novel prognostic biomarker in Bc is not well understood. The current study applied immunohistochemistry (IHc) staining and analyzed the association between Rab22a expression and clinicopathological features, as well as OS status.…”

Section: Rab22a Is a Novel Prognostic Marker For Cell Progression In mentioning

confidence: 99%

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Rab22a is a novel prognostic marker for cell progression in breast cancer

Shen

Jiang

et al. 2020

Int J Mol Med

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Breast cancer (Bc) is the most common female malignant tumor worldwide. The mechanism of tumorigenesis is still unclear. Ras-related proteins in brain (Rab)22a belongs to the Ras superfamily, which may act as an oncogene and participate in carcinogenesis. The present study aims to identify whether Rab22a could be a novel biomarker of prognosis and determine the effects of Rab22a on Bc cell progression. A total 258 BC and 56 para-tumor or non-tumor formalin fixed paraffin embedded tissues were stained through immunohistochemistry. The association between Rab22a expression and clinicopathological features, as well as overall survival status were analyzed. The expression level of Rab22a in breast cell lines were detected using reverse transcription-quantitative PcR and western blotting. SK-BR-3 cells were infected with Rab22a short hairpin RNA lenti-virus and the ability of cell proliferation, migration and invasion were measured. Gene Set Enrichment Analysis (GSEA) was employed to analyze the pathways involved in the Rab22a mRNA high level group. Rab22a was found to be overexpressed in BC tissues and upregulated in BC cells. High expression of Rab22a was related to a poor prognosis of patients with Bc. Knockdown of Rab22a decreased the proliferation, migration and invasion ability of Bc cells. GSEA indicated that certain pathways, including mammalian target of rapamycin complex 1 and protein secretion were upregulated, while pathways, such as hypoxia and KRas were downregulated in the Rab22a high level group. Rab22a is of prognostic value for Bc and necessary for Bc cell proliferation.

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Section: Rab22a Is a Novel Prognostic Marker For Cell Progression In mentioning

confidence: 99%

Section: Rab22a Is a Novel Prognostic Marker For Cell Progression In mentioning

confidence: 99%

Rab22a is a novel prognostic marker for cell progression in breast cancer

Shen

Jiang

et al. 2020

Int J Mol Med

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“…As a result, this horizontal transfer triggered the development of therapy-resistant metastases in BC ( Sansone et al, 2017a ). Furthermore, a recent study revealed that O 2 -3-Aminopropyl diazeniumdiolates 3a–f was created to markedly suppress the metastatic ability of TNBC by attenuating microvesicles formation in an NO-dependent manner ( Kang et al, 2018 ). Welte et al (2016) highlighted that the mTOR pathway promoted G-Colony-stimulating factors expression in preclinical models of BC which further resulted in immunosuppressive tumor microenvironment.…”

Section: The Effects Of Exosomes In the Breast Cancer Tumor Microenvironmentmentioning

confidence: 99%

The Advancing Roles of Exosomes in Breast Cancer

Wang

Sun

Huang

et al. 2021

Front. Cell Dev. Biol.

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Breast cancer (BC) develops from breast tissue and is the most common aggressive malignant tumor in women worldwide. Although advanced treatment strategies have been applied and reduced current mortality rates, BC control remains unsatisfactory. It is essential to elucidate the underlying molecular mechanisms to assist clinical options. Exosomes are a type of extracellular vesicles and mediate cellular communications by delivering various biomolecules (oncogenes, oncomiRs, proteins, and even pharmacological compounds). These bioactive molecules can be transferred to change the transcriptome of target cells and influence tumor-related signaling pathways. Extensive studies have implicated exosomes in BC biology, including therapeutic resistance and the surrounding microenvironment. This review focuses on discussing the functions of exosomes in tumor treatment resistance, invasion and metastasis of BC. Moreover, we will also summarize multiple interactions between exosomes and the BC tumor microenvironment. Finally, we propose promising clinical applications of exosomes in BC.

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“…The NO donor, CAP-NO, inhibited the basal and cytokine-stimulated adhesion of human colorectal cancer cells HT-29 to endothelial cells by inhibiting the expression of adhesion proteins ELAM-1, ICAM-1, and particularly VCAM-1 (Lu et al, 2014). NO donors inhibits the adhesion of MDA-MB231 cells to HUVEC stimulated by IL-1β and the transmigration of breast cancer cells across the lung microvascular endothelium (Kang et al, 2018;Stojak et al, 2018). This effect was mediated by a decrease in ICAM-1 expression.…”

Section: No and Tumor Cell Adhesionmentioning

confidence: 99%