Thiosulfate promotes hair growth in mouse model

Abstract

The present study describes the hair growth-promoting effects of sodium thiosulfate (STS), a widely used compound, in mice. STS accelerated hair growth in the "telogen model", suggesting that it stimulates telogen hair follicles to reenter the anagen phase of hair growth. In the same model, STS potentiated hair growth in an additive manner with minoxidil (MXD), a drug used for the treatment of androgenic alopecia. Furthermore, in the "anagen model", STS promoted hair growth, probably by promoting hair follicle proliferation. Since STS elevated the skin surface temperature, its hair growth-promoting activity may be partly due to vasorelaxation, similar to MXD. In addition, STS is known to generate a gaseous mediator, HS, which has vasorelaxation and anti-inflammatory/anti-oxidative stress activities. Therefore, STS and/or provisionally its metabolite, HS, may aid the hair growth process. Collectively, these results suggest that salts of thiosulfate may represent a novel and beneficial remedy for hair loss.

Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology

“…Then, we examined hair follicles as a source of biomarker genes ( n = 166 for control and n = 149 for schizophrenia) (Maekawa et al , ). The MPST was the only substantially expressed transcript among the three genes for H 2 S synthesis in this mini‐organ (Figs H and EV3) (Maekawa et al , ), and MPST mRNA expression was increased in subjects with schizophrenia (Fig I, ). None of the confounding factors, such as age at examination, BMI (body mass index), anti‐psychotic drug dose, age of onset of schizophrenia, duration of the illness, and smoking, were significantly correlated with MPST mRNA expression in scalp hair follicles ().…”

Hair Growth Promoting Effect of Dicerocaryum senecioides Phytochemicals

“…us any positive hair growth on denuded mice is less attributed to the natural mice hair growth cycle but the treatment which triggers a transformation into the anagen, which is the active hair growth phase. A er the rst treatment, no mice were not subjected to the second treatment because the second hair growth in mice is not synchronized as not all hairs will be in the same phase of growth [12]. Physiological processes such as pregnancy and lactation were prevented during the experimental period by keeping the male and female mice in separate cages.…”

“…It is paramount, however, for a researcher to understand hair growth cycle patterns of rodents before selection. Synchronized hair growth in rodents is only when the rodents are young, therea er numerous hair cycle patterns come into play, each with a different regeneration rhythm [12,13]. us it will be difficult to have all the hair follicles in the same growth phase at any time a er the completion of the first hair growth cycle.…”

Hydrogen sulfide: Recent progress and perspectives for the treatment of dermatological diseases

“…Androgenic alopecia is a chronic, progressive condition affecting millions of individuals worldwide. Sodium thiosulfate (STS), known to generate H 2 S, accelerates hair growth in the “telogen model” of mice, suggesting that H 2 S stimulates telogen hair follicles to reenter the anagen phase of hair growth [62] . H 2 S may represent a novel and beneficial remedy for hair loss in androgenic alopecia.…”