Responses of Angiogenic Regulators to Resistance Exercise Under Systemic Hypoxia

Kon, Michihiro; Ikeda, Toshihide; Homma, Toshiyuki; Suzuki, Yasuhiro

doi:10.1519/jsc.0000000000002695

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…Based on the effects of hypoxia-induced increases in metabolic stress, anabolic hormones, cytokines, and/or cellular swelling, among others 4 , 6 , 9 , 11 , 12 , RTH conceivably could promote greater improvements in muscle size and strength than the same training regimen carried out in normoxia (RTN) 11 , 13 , 14 . Conceivably, these improvements could therefore be achieved under hypoxic conditions in a shorter time period compared to training under normoxic conditions 5 , 15 .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of resistance training in hypoxia on muscle hypertrophy and strength development: a systematic review with meta-analysis

Benavente

Schöenfeld

Padial

et al. 2023

Sci Rep

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A systematic review and meta-analysis was conducted to determine the effects of resistance training under hypoxic conditions (RTH) on muscle hypertrophy and strength development. Searches of PubMed-Medline, Web of Science, Sport Discus and the Cochrane Library were conducted comparing the effect of RTH versus normoxia (RTN) on muscle hypertrophy (cross sectional area (CSA), lean mass and muscle thickness) and strength development [1-repetition maximum (1RM)]. An overall meta-analysis and subanalyses of training load (low, moderate or high), inter-set rest interval (short, moderate or long) and severity of hypoxia (moderate or high) were conducted to explore the effects on RTH outcomes. Seventeen studies met inclusion criteria. The overall analyses showed similar improvements in CSA (SMD [CIs] = 0.17 [− 0.07; 0.42]) and 1RM (SMD = 0.13 [0.0; 0.27]) between RTH and RTN. Subanalyses indicated a medium effect on CSA for longer inter-set rest intervals and a small effect for moderate hypoxia and moderate loads favoring RTH. Moreover, a moderate effect for longer inter-set rest intervals and a trivial effect for severe hypoxia and moderate loads favoring RTH was found on 1RM. Evidence suggests that RTH employed with moderate loads (60–80% 1RM) and longer inter-set rest intervals (≥ 120 s) enhances muscle hypertrophy and strength compared to normoxia. The use of moderate hypoxia (14.3–16% FiO2) seems to be somewhat beneficial to hypertrophy but not strength. Further research is required with greater standardization of protocols to draw stronger conclusions on the topic.

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Section: Introductionmentioning

confidence: 99%

Efficacy of resistance training in hypoxia on muscle hypertrophy and strength development: a systematic review with meta-analysis

Benavente

Schöenfeld

Padial

et al. 2023

Sci Rep

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“…VEGF can regulate the proliferation of vascular endothelial cells and maintain the stability of cardiovascular function under hypoxia. In addition, it can compensate for anoxic myocardial tissue by establishing new collateral circulation35 . However, under conditions of long-term hypoxia, the vascular endothelial function becomes unbalanced.…”

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confidence: 99%

Effect of mandibular advancement device treatment on HIF-1α, EPO and VEGF in the myocardium of obstructive sleep apnea–hypopnea syndrome rabbits

Zhu

Kang

Zhang

et al. 2020

Sci Rep

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All methods in this study were performed in accordance with the medical ethics committee in Hospital of Stomatology, Hebei Medical University. Animal use and care was in accordance with the guidelines of the medical ethics committee for the housing and care of animals bred, supplied and used for scientific purposes. All experiments were performed in accordance with relevant guidelines and regulations. The work was approved by the medical ethics committee in Hospital of Stomatology, Hebei Medical University (Certificate No. [2017]016). Animal model development. Every effort was made to minimize animal pain and suffering. A total of 18 male 6-month-old New Zealand white rabbits (initial weight, 3-3.5 kg) were randomly divided into three groups: the OSHAS, MAD, and control groups, with 6 rabbits in each group. All of the animals were housed under normal laboratory conditions. Food and water were available ad libitum. The animal models were developed in the same way as in our previous studies 12,13. Briefly, OSAHS was induced via injection of gel into the submucous muscular layer in the centre of the soft palate 1.5 cm away from the junction of the soft and hard palate (Fig. 1). No gel was injected in the control group. Animals in these two groups were later confirmed to have OSAHS by clinical signs, CBCT scanning and polysomnography (PSG).

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Repeated sprint training under hypoxia improves aerobic performance and repeated sprint ability by enhancing muscle deoxygenation and markers of angiogenesis in rugby sevens

2022

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Responses of Angiogenic Regulators to Resistance Exercise Under Systemic Hypoxia

Cited by 5 publications

References 28 publications

Efficacy of resistance training in hypoxia on muscle hypertrophy and strength development: a systematic review with meta-analysis

Efficacy of resistance training in hypoxia on muscle hypertrophy and strength development: a systematic review with meta-analysis

Effect of mandibular advancement device treatment on HIF-1α, EPO and VEGF in the myocardium of obstructive sleep apnea–hypopnea syndrome rabbits

Repeated sprint training under hypoxia improves aerobic performance and repeated sprint ability by enhancing muscle deoxygenation and markers of angiogenesis in rugby sevens

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