The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle

Canciglieri, Paulo Henrique; Kuga, Gabriel Keine; Muñoz, Vitor Rosetto; Gaspar, Rafael Calais; Rocha, Aristides Almeida; Breda, Leonardo; Anaruma, Chadi Pellegrini; Minuzzi, Luciéle Guerra; Silva, Adelino Sánchez Ramos da; Cintra, Dennys Esper; Moura, Leandro Pereira de; Ropelle, Eduardo Rochete; Pauli, José Rodrigo

doi:10.1016/j.lfs.2018.09.006

Cited by 8 publications

(6 citation statements)

References 21 publications

(37 reference statements)

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“…However, our findings do agree with those of Masoro and colleagues [32] who uncovered age-related differences of circadian blood glucose in aging F344 rats while others found no changes when only sampling blood at single time points during the light phase [33] , [34] , [35] . The present and published data are also aligned with impaired glucose tolerance of male F344 rats at 26–27 months of age [36] , [37] .…”

Section: Discussionsupporting

confidence: 83%

Daily fluctuations in blood glucose with normal aging are inversely related to hippocampal synaptic mitochondrial proteins

Braunstein,

Horovitz,

Hampton

et al. 2024

Aging Brain

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Section: Discussionsupporting

confidence: 83%

Daily fluctuations in blood glucose with normal aging are inversely related to hippocampal synaptic mitochondrial proteins

Braunstein,

Horovitz,

Hampton

et al. 2024

Aging Brain

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“…Matos et al (2010) demonstrated that acute exercise reverses TRIB3 expression and insulin signaling restoration in muscle. Canciglieri et al (2018), however, reported that TRIB3 content was not altered after short-duration physical exercise with a 10 • inclination. In the current study, the increase in TRIB3 was dampened and AKT phosphorylation was increased after 8 weeks of downhill running training and dietary fat regulation.…”

Section: Discussionmentioning

confidence: 91%

Modulation of TRIB3 and Macrophage Phenotype to Attenuate Insulin Resistance After Downhill Running in Mice

et al. 2021

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Eccentric exercise training accompanied by a low-fat diet can prevent insulin resistance (IR) and is currently an effective method for the treatment of IR induced by high-fat diet (HFD)-associated obesity. However, the molecular mechanisms underlying this improvement of IR in adipose tissue are still not completely clear. In this study, 5–6-week-old male mice were randomly divided into a standard control diet (SCD) group (SC, n = 12) and a HFD group (HF, n = 72). After 12 weeks, 12 mice in each group were randomly sacrificed. The remaining mice in the HF group were randomly submitted to one of the following experimental protocols for 8 weeks: obesity-HFD-sedentary (OHF-Sed, n = 14), obesity-HFD-exercise (OHF-Ex, n = 16), obesity-SCD-sedentary (OSC-Sed, n = 14), and obesity-SCD-exercise (OSC-Ex, n = 16). All obese mice in the exercise group were subjected to downhill running. Half of the mice in each group received an insulin injection (0.75 U/kg) before sample collection. Epididymal fat was removed and weighed. Adipocyte size and inflammatory cell infiltration were observed by H&E staining. Both basal and insulin-stimulated GLUT4 fluorescence and protein contents were detected by immunofluorescence and Western blot. Levels of IL-1β and IL-10 were detected by ELISA. Protein contents of iNOS, Arg-1, TRIB3, p-AKT, and AKT were determined by Western blot. CD86 and CD206 fluorescence were determined by immunofluorescence. The results showed that a HFD for 12 weeks induced IR accompanied by adipose tissue macrophages M1 polarization (increased iNOS protein content and CD86 fluorescence) and TRIB3-AKT activation. Downhill running accompanied by a low-fat diet attenuated IR (p < 0.01), reduced inflammation levels (increased IL-10 protein content and decreased IL-1β protein content), inhibited adipose tissue macrophages M1 polarization (decreased iNOS protein content and CD86 fluorescence) and promoted M2 polarization (increased Arg-1 protein content and CD206 fluorescence), and suppressed TRIB3-AKT signaling. We concluded that downhill running accompanied by dietary fat regulation attenuates HFD-related IR in mice, which may be associated with reduced TRIB3-AKT signaling and activated M2 macrophages in adipose tissue.

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“…The adaptor protein APPL2 (leucine zipper motif isoform 2) is able to interfere with the AdipoR (adiponectin receptors 1 and 2)-APPL1 interaction involved in the adiponectin pathway [144]. Studies on murine models revealed that exercise might have beneficial effects on insulin sensitivity by diminishing the content of APPL2 in the skeletal muscles of older Fischer 344 rats [145]. Furthermore, research indicates that regular exercise may reduce the impact of aging-related insulin sensitivity in humans [146].…”

Section: Age-related Hormonal Changes and Physical Activitymentioning

confidence: 99%

Inactivity and Skeletal Muscle Metabolism: A Vicious Cycle in Old Age

Rezuş

Burlui

Cardoneanu

et al. 2020

IJMS

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Aging is an inevitable and gradually progressive process affecting all organs and systems. The musculoskeletal system makes no exception, elderly exhibit an increased risk of sarcopenia (low muscle mass),dynapenia (declining muscle strength), and subsequent disability. Whereas in recent years the subject of skeletal muscle metabolic decline in the elderly has been gathering interest amongst researchers, as well as medical professionals, there are many challenges yet to be solved in order to counteract the effects of aging on muscle function efficiently. Noteworthy, it has been shown that aging individuals exhibit a decline in skeletal muscle metabolism, a phenomenon which may be linked to a number of predisposing (risk) factors such as telomere attrition, epigenetic changes, mitochondrial dysfunction, sedentary behavior (leading to body composition alterations), age-related low-grade systemic inflammation (inflammaging), hormonal imbalance, as well as a hypoproteic diet (unable to counterbalance the repercussions of the age-related increase in skeletal muscle catabolism). The present review aims to discuss the relationship between old age and muscle wasting in an effort to highlight the modifications in skeletal muscle metabolism associated with aging and physical activity.

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The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle

Cited by 8 publications

References 21 publications

Daily fluctuations in blood glucose with normal aging are inversely related to hippocampal synaptic mitochondrial proteins

Daily fluctuations in blood glucose with normal aging are inversely related to hippocampal synaptic mitochondrial proteins

Modulation of TRIB3 and Macrophage Phenotype to Attenuate Insulin Resistance After Downhill Running in Mice

Inactivity and Skeletal Muscle Metabolism: A Vicious Cycle in Old Age

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