[Erratum] Tanshinone�IIA and Astragaloside�IV promote the angiogenesis of mesenchymal stem cell‑derived endothelial cell‑like cells via upregulation of Cx37, Cx40 and Cx43

Li, Zhe; Zhang, Sha; Cao, Liang; Li, Wei; Ye, Yuchen; Shi, Zixuan; Wang, Zongren; Sun, Liguo; Wang, Jia‐Wei; Jia, Lintao; Wang, Wen

doi:10.3892/etm.2018.6428

Cited by 17 publications

(14 citation statements)

References 39 publications

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“…AS IV also inhibits proliferation and migration of human dermal vascular smooth muscle cells, stimulated by PDGF-BB secreted during vascular injury, through inhibition of p38 MAPK signaling (Chen et al, 2014). It has also been reported that AS IV and Tan IIA promote tubular structure formation of BMSC-derived endothelial cell cells, similar to that of blood vessels, via the expression of connexins and cell connection (Li et al, 2018b).…”

Section: Astragaloside IVmentioning

confidence: 88%

Recruitment of Mesenchymal Stem Cells to Damaged Sites by Plant-Derived Components

Maeda

2020

Front. Cell Dev. Biol.

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Mesenchymal stem cells (MSCs) are capable of differentiating into a limited number of diverse cells and secrete regenerative factors that contribute to the repair of damaged tissue. In response to signals emitted by tissue damage, MSCs migrate from the bone marrow and area surrounding blood vessels within tissues into the circulating blood, and accumulate at the site of damage. Hence, MSC transplantation therapy is beginning to be applied to the treatment of various intractable human diseases. Recent medicinal plants studies have shown that plant-derived components can activate cell functions. For example, several plant-derived components activate cell signaling pathways, such as phosphatidylinositol 3-kinase and mitogen-activated protein kinase (MAPK), enhance expression of the CXCL12/CXCR4 axis, stimulate extracellular matrix remodeling, and consequently, promote cell migration of MSCs. Moreover, plant-derived components have been shown to promote recruitment of MSCs to damaged tissues and enhance healing in disease models, potentially advancing their therapeutic use. This article provides a comprehensive review of several plant-derived components that activate MSC migration and homing to damaged sites to promote tissue repair.

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Section: Astragaloside IVmentioning

confidence: 88%

Recruitment of Mesenchymal Stem Cells to Damaged Sites by Plant-Derived Components

Maeda

2020

Front. Cell Dev. Biol.

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“…The animal model of intracerebral hemorrhagic brain edema has been widely used to study the etiology and pathology of brain edema in humans (14)(15)(16). Brain edema after cerebral hemorrhage could cause extensive edema (11)(12)(13), and preventing the occurrence or aggravation of brain edema is an important factor to reduce the mortality and disability rates of cerebral hemorrhage (17). The previous animal models were unable to fully reflect the clinical and pathophysiological manifestations of cerebral hemorrhage brain edema (18)(19)(20); therefore, it was very important to establish a compound animal model of cerebral hemorrhage brain edema.…”

Section: Discussionmentioning

confidence: 99%

Establishment of composite experimental animal model of brain edema after cerebral hemorrhagic

Zhao

Zhang²

2021

Ann Palliat Med

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Background: The aim of our study was to explore the establishment of an animal model of compound cerebral edema and assist the study of brain edema. Methods: Sprague Dawley (SD) rats were randomly divided into 6 groups: Group A (IV collagenase + heparin autologous blood + non-heparin autologous blood), Group B (heparin autologous blood), Group C (IV collagenase), Group D (non-heparin autologous blood), Group E (control), Group F (sham); groups A, B, C, and D were modeled, group E received no treatment, and group F was injected with normal saline. The Longa/Bederson scales were used to test limb symmetry and score neurological deficits. The composition of brain tissue were measured by potassium (K +), sodium (Na +), and calcium (Ca 2+). The glial cells were also subjected to primary culture and identification. The flow cytometry technique (FCM) and terminal uridine nick-end labeling (TUNEL) test were used to detect for the apoptosis of glial cells. Cell counting Kit-8 (CCK-8) and 5-ethynyl-2'-deoxyuridine (EdU) assays were used to observe the proliferation of glial cells; quantitative real-time polymerase chain reaction (qPCR) and western blot measured glial cell matrix metalloproteinase 9 (MMP-9) hole channel protein 4 messenger (m)RNA, and protein expression. The scratch and transwell tests were used to study the glial cell migration and invasion. Results: Among all groups, according to the results of the Longa/Bederson scores of neurologic impairment, brain tissue water content, and electrolyte K + , Na + , Ca 2+ , group A showed the most significance (P<0.05). Group A showed the highest rate of apoptosis (32.27±3.33), least proliferation (5.33±1.14), and migration and invasion ability were the weakest (85.35±8.11; 8.08±1.96). The mRNA (9.31±0.84; 15.69±1.77) and protein (4.25±0.27; 4.34±0.33) of MMP-9 and aquaporin-4 (AQP4) were the most significant in group A (P<0.05). Inter-group comparison of groups B, C, and D and between groups E and F yielded no significant differences (P>0.05). Conclusions: By using the obvious signs of brain edema, we were able to establish a composite experimental animal model for the study of brain edema after cerebral hemorrhage, to provide a reliable experimental basis for the study of brain edema.

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“…A large number of studies have revealed that whether stem cells develop into cardiomyocytes [59,60] and vascular endothelial cells [61][62][63] or differentiate into neurons [64][65][66] and osteoblasts [67,68], the Shh signaling pathway plays an important role. Astragaloside IV promoted mesenchymal stem cells into neuronal cells [69], endothelial cells [22], and cardiomyocytes [70]. e angiogenesis and cardiomyocyte survival induced by astragaloside IV in rats with acute Evidence-Based Complementary and Alternative Medicine myocardial infarction attributed to upregulation of the gene expression of Shh pathway and their activity of receptors and signal transducers [71].…”

Section: Shh/gli1mentioning

confidence: 99%

“…Our previous studies have found that bavachalcone, an isopentenyl chalcone from Psoralea corylifolia Linn., promoted the differentiation of EPCs and neovascularization in vivo [19]. In a series of cell-based experiments, Tang and his colleagues observed that ginkgolide B, icariin, tanshinone IIA, astragaloside IV, ginsenoside Rg1, and salidroside exert angiogenic endothelial differentiation effects of human bone marrow-derived EPCs [20][21][22][23][24]. A study reported that salvianolic acid A could augment EPC numbers and promote EPC migration, adhesion, and the vasculogenesis capacity in myocardial ischemia-reperfusion (I/R) rat model [25].…”

Section: Endothelial Cell and Cardiomyocyte Differentiationmentioning

confidence: 99%

Effect of Active Ingredients of Chinese Herbal Medicine on the Rejuvenation of Healthy Aging: Focus on Stem Cells

Wang

Ling

2020

Evidence-Based Complementary and Alternative Medicine

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Stem cells (SCs) are special types of cells with the ability of self-renewal and multidirectional differentiation. As the organism ages, the ability to maintain homeostasis and regeneration deteriorates and the number and activity of stem cells decline. Theoretically, the restoration of stem cells might reverse aging. However, due to their own aging, donor-derived immune rejection, and difficulties in stem cell differentiation control, a series of problems need to be solved to realize the potential for clinical application of stem cells. Chinese herbal medicine is a nature drug library which is suitable for the long-term treatment of aging-related diseases. Modern pharmacological studies have revealed that many active ingredients of Chinese herbal medicines with the effect of promoting stem cells growth and differentiation mainly belong to “reinforcing herbs.” In recent years, exploration of natural active ingredients from Chinese herbal medicines for delaying aging, improving the stem cell microenvironment, and promoting the proliferation and differentiation of endogenous stem cells has attracted substantial attention. This article will focus on active ingredients from Chinese herbs-mediated differentiation of stem cells into particular cell type, like neural cells, endothelial cells, cardiomyocytes, and osteoblasts. We will also discuss the effects of these small molecules on Wnt, Sonic Hedgehog, Notch, eNOS-cGMP, and MAP kinase signal transduction pathways, as well as reveal the role of estrogen receptor α and PPAR γ on selectively promoting or inhibiting stem cells differentiation. This review will provide new insights into the health aging strategies of active ingredients in Chinese herbal medicine in regenerative medicine.

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[Erratum] Tanshinone�IIA and Astragaloside�IV promote the angiogenesis of mesenchymal stem cell‑derived endothelial cell‑like cells via upregulation of Cx37, Cx40 and Cx43

Cited by 17 publications

References 39 publications

Recruitment of Mesenchymal Stem Cells to Damaged Sites by Plant-Derived Components

Recruitment of Mesenchymal Stem Cells to Damaged Sites by Plant-Derived Components

Establishment of composite experimental animal model of brain edema after cerebral hemorrhagic

Effect of Active Ingredients of Chinese Herbal Medicine on the Rejuvenation of Healthy Aging: Focus on Stem Cells

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