Correlation Between the Number of Ghrelin-Secreting Cells in the Gastric Fundus and Excess Weight Loss after Sleeve Gastrectomy

Itlaybah, Abdulaziz; Elbanna, Hosam Ghazy; Emile, Sameh Hany; Thabet, Waleed; Elkashef, Wagdi; Abdelsalam, Noha; AbdelMawla, Ahmed; Elkaffas, Haitham

doi:10.1007/s11695-018-3498-z

Cited by 11 publications

(5 citation statements)

References 23 publications

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“…Lin et al 18 reported that complete resection of the gastric fundus may help in ghrelin suppression and prevent the increase in ghrelin levels after 6 months of the procedure. Another study 19 reported a strong positive correlation between plasma ghrelin levels and the total number of ghrelin-producing cells in the gastric fundus, which indicates that complete removal of the fundus would help reduce ghrelin levels in a substantial manner.…”

Section: Discussionmentioning

confidence: 97%

Fasting Ghrelin and Postprandial GLP-1 Levels in Patients With Morbid Obesity and Medical Comorbidities After Sleeve Gastrectomy and One-anastomosis Gastric Bypass: A Randomized Clinical Trial

Roushdy

Abdel-Razik

Emile

et al. 2020

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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Background: Sleeve gastrectomy (SG) and one-anastomosis gastric bypass (OAGB) are among the commonly performed bariatric procedures. This randomized study aimed to compare SG and OAGB in terms of weight loss, improvement in comorbidities, and change in serum ghrelin and glucagon-like peptide-1 (GLP-1) levels.Patients and Methods: This was a prospective randomized trial on patients with morbid obesity associated with medical comorbidities who were randomly assigned to 1 of 2 equal groups; group I underwent SG and group II underwent OAGB. Outcome measures were percent of excess weight loss (%EWL), improvement in comorbidities, change in the venous levels of fasting ghrelin and postprandial GLP-1 at 12 months after surgery, in addition to operation time and complications.Results: Forty patients (38 female) of a mean age of 33.8 years and mean body mass index of 48.6 kg/m 2 were included. Operation time in group II was significantly longer than in group I (86 vs. 52.87 min; P < 0.001). There were 6 recorded complications (1 in group I and 5 in group II, P = 0.18). The %EWL, %total weight loss, and %excess body mass index loss at 6 and 12 months postoperatively were significantly higher in group II than in group I. Both groups had similar rates of improvement in comorbidities. Group I had significantly lower ghrelin and GLP-1 levels postoperatively at 6 and 12 months, respectively, as compared with group II.Conclusions: OAGB was associated with significantly higher EWL than SG. The reduction in fasting ghrelin and postprandial GLP-1 serum levels at 12 months after SG was significantly higher than that after OAGB.

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Section: Discussionmentioning

confidence: 97%

Fasting Ghrelin and Postprandial GLP-1 Levels in Patients With Morbid Obesity and Medical Comorbidities After Sleeve Gastrectomy and One-anastomosis Gastric Bypass: A Randomized Clinical Trial

Roushdy

Abdel-Razik

Emile

et al. 2020

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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“…Furthermore, another investigation discovered a robust positive correlation between plasma Ghrelin levels and the total number of Ghrelin-producing cells in the gastric fundus. This suggests that complete resection of the gastric fundus could effectively reduce Ghrelin levels [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation analysis between the changes in plasma ghrelin level and weight loss after sleeve gastrectomy combined with fundoplication

Li,

Aili,

Aipire

et al. 2024

BMC Surg

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Background Laparoscopic sleeve gastrectomy combined with fundoplication (LSGFD) can significantly control body weight and achieve effective anti-reflux effects. The aim of this study is to investigate the correlation between the alteration in Ghrelin levels and weight loss following SGFD, and to compare Ghrelin levels, weight loss and metabolic improvements between SG and SGFD, with the objective of contributing to the existing body of knowledge on SGFD technique in the management of patients with obesity and gastroesophageal reflux disease (GERD). Methods A retrospective analysis was conducted on the clinical data of 115 obese patients who underwent bariatric surgery between March 2023 and June 2023 at the Department of Minimally Invasivew Surgery, Hernia and Abdominal Wall Surgery, People’s Hospital of Xinjiang Uygur Autonomous Region. The subjects were divided into two groups based on surgical methods: sleeve gastrectomy group (SG group, 93 cases) and sleeve gastrectomy combined with fundoplication group (SGFD group, 22 cases). Clinical data, such as ghrelin levels before and after the operation, were compared between the two groups, and the correlation between changes in ghrelin levels and weight loss effectiveness after the operation was analyzed. Results: Three months after the operation, there was no significant difference in body mass, BMI, EWL%, fasting blood glucose, triglyceride, cholesterol, and uric acid levels between the SG and SGFD groups (P > 0.05). However, the SGFD group exhibited a significant decrease in body weight, BMI, and uric acid levels compared to preoperative levels (P < 0.05), while the decrease in ghrelin levels was not statistically significant (P > 0.05). Logistic regression analysis indicated that ghrelin levels three months after the operation were influential in postoperative weight loss. Conclusion The reduction of plasma Ghrelin level in patients after SGFD is not as obvious as that in patients after SG, but it can make obese patients get the same good weight loss and metabolic improvement as patients after SG. Ghrelin level at the third month after operation is the influencing factor of postoperative weight loss.

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“…More recent work in humans has illustrated that the amount of stomach may be less important compared to the endocrine cells (ghrelin receptors) present in the stomach that is resected so histopathological studies are also necessary. 21 Traditional open partial gastrectomy is already performed in veterinary medicine for gastric necrosis associated with gastric dilatation volvulus and gastric neoplasia. [22][23][24][25] Complications encountered during these procedures include hemorrhage and leakage of gastric contents from subsequent dehiscence, but the true incidence is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…As this technique appears safe in a live animal model future work is underway to determine the specific amount of stomach that must be removed in feline patients to generate weight loss. More recent work in humans has illustrated that the amount of stomach may be less important compared to the endocrine cells (ghrelin receptors) present in the stomach that is resected so histopathological studies are also necessary 21 …”

Section: Discussionmentioning

confidence: 99%

Laparoscopic vertical sleeve gastrectomy in felines: A cadaveric feasibility study and experimental case series in two cats

et al. 2022

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ObjectiveTo evaluate the feasibility of laparoscopic vertical sleeve gastrectomy (LVSG) in feline cadavers using endoscopic stapling equipment and report clinical outcomes in two live feline subjects.Study designCadaveric study and experimental case series.AnimalsTen feline cadavers; two feline subjects.MethodsLVSG technique was refined on feline cadavers and included retraction of the liver, dissection of the stomach, assessment of proper location for gastrectomy via stapling, and leak testing. Appropriateness of gastrectomy, gastrectomy %, surgical times and complications were recorded. The procedure was performed on two live feline subjects, and they were followed for 4 months to report surgical complications.ResultsLVSG was completed in 9/10 cadavers and both live patients. Stenosis at the incisura was recorded in 2/9 cadavers. No obvious leaks were seen in the 8 cadavers that were tested or either live patient. The mean surgical time for all cadaver procedures and live patients was 110.4 and 115 minutes, respectively. Mean weight of resected cadaver stomach was 10 g and the mean % of the total stomach weight resected was 27.6%. No intra‐ or postoperative surgical complications occurred in the live subjects.ConclusionLVSG technique appears feasible and safe for use in live patients.Clinical relevance: This LVSG technique may be safely used for partial gastric resection in cats. Further studies are necessary to determine if it is effective at reversing the effects of obesity and diabetes in this population.

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Correlation Between the Number of Ghrelin-Secreting Cells in the Gastric Fundus and Excess Weight Loss after Sleeve Gastrectomy

Abstract: There was a weak correlation between the total number of ghrelin-producing cells in the gastric fundus and plasma ghrelin levels with EWL after LSG.

Cited by 11 publications

References 23 publications

Fasting Ghrelin and Postprandial GLP-1 Levels in Patients With Morbid Obesity and Medical Comorbidities After Sleeve Gastrectomy and One-anastomosis Gastric Bypass: A Randomized Clinical Trial

Fasting Ghrelin and Postprandial GLP-1 Levels in Patients With Morbid Obesity and Medical Comorbidities After Sleeve Gastrectomy and One-anastomosis Gastric Bypass: A Randomized Clinical Trial

Correlation analysis between the changes in plasma ghrelin level and weight loss after sleeve gastrectomy combined with fundoplication

Laparoscopic vertical sleeve gastrectomy in felines: A cadaveric feasibility study and experimental case series in two cats

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