The relationship between quality of life, cognition, and thyroid status in Graves’ disease

Riguetto, Cínthia Minatel; Moura, Arnaldo Vieira; Tambascia, Marcos Antônio; Zantut-Wittmann, Denise Engelbrecht

doi:10.1007/s12020-018-1733-y

Cited by 35 publications

(39 citation statements)

References 30 publications

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“…Several clinical evidences have demonstrated that the patients with hyperthyroidism have affective and cognitive impairments such as irritability, anxiety, inability to concentrate, forgetfulness and so on. [4][5][6][7] The patients with hyperthyroidism have higher scores of anxiety and depression than healthy control using various self-rating scales and other-rating scales. [8][9][10][11] Our previous data have revealed that the patients with hyperthyroidism experience impairments of the attention networks.…”

Section: Introductionmentioning

confidence: 99%

<p>Reversible Affective Symptoms and Attention Executive Control Network Impairment Following Thyroid Function Normalization in Hyperthyroidism</p>

Yuan

Zhang

Luan

et al. 2019

NDT

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Introduction: Affective symptoms and attention impairments are found in patients with hyperthyroidism. Our previous data have revealed that the patients with hyperthyroidism experience impairments of the attention networks, but it remains unclear whether these disorders persist after the treatment of hyperthyroidism. Methods: Twenty healthy controls and 25 hyperthyroid patients were recruited and performed the attention network test (ANT) which can simultaneously examine the alertness, orientation and execution control components of the participants. The effect of treatment on affective symptom and attention networks impairments were examined in the patient group after 1-year anti-thyroid medication and reaching euthyroidism for at least 3 months. Results: Anxiety and depression scores of patients with hyperthyroidism were significantly higher than those of the healthy control group. The patients with hyperthyroidism had impairments of the alerting and executive control networks. Meanwhile, the score of HAMA correlated significantly with thyroid hormone and TSH levels, and there was a negative significant correlation between the score of HAMD and TSH level in all subjects. There was a positive correlation between the value of the executive control network and thyroid hormones' levels in all subjects and in the hyperthyroidism group. Anxiety and depression symptoms were improved with methimazole treatment after euthyroidism was reached. The value of the executive control network no longer differed from that of healthy controls, but deficits in the alerting network of hyperthyroidism still persisted after treatment. Conclusion: The patients with hyperthyroidism existed affective symptoms and attention networks impairments. Affective symptoms and attention executive control network impairment were improved following thyroid function normalization in hyperthyroidism.

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Section: Introductionmentioning

confidence: 99%

<p>Reversible Affective Symptoms and Attention Executive Control Network Impairment Following Thyroid Function Normalization in Hyperthyroidism</p>

Yuan

Zhang

Luan

et al. 2019

NDT

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“…They concluded that usual clinical assessment seems to be unrelated to the negative impact on quality of life [3]. Regarding well-being among Graves' disease patients with or without ophthalmopathy assessed by HRQoL, GO-QOL and Mini-Mental State Examination, Riguetto CM et al found that the presence of ophthalmopathy was a factor related to poor quality of life [21].…”

Section: Discussionmentioning

confidence: 99%

Development and psychometric properties of the Thai Graves’ ophthalmopathy quality of life (GO-QOL) questionnaire

Lumyongsatien

Keeratidamkerngsakul

Pornpanich

et al. 2019

J Patient Rep Outcomes

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Purpose: To develop and assess the psychometric properties of the Thai version of the Graves' Ophthalmopathy Quality of Life (GO-QOL) questionnaire. Background: Graves' ophthalmopathy (GO) is a chronic condition that causes negative self-image and impaired visual function. These conditions impact quality of life (QOL) but are rarely documented. Graves' Ophthalmopathy Quality of Life Questionnaire (GO-QOL) has good validity, reliability and responsiveness. In this study we developed a Thai GO-QOL questionnaire by translating the questionnaire from English to the Thai language and evaluated its reliability and validity. Patients and methods: Forward and backward translations were performed independently by four translators with extensive experience in both English and Thai. Seventy patients at the thyroid clinic responded to the Thai translated version upon their first visit and again 2-3 weeks afterwards. Validity was assessed by the content validity index (CVI) and correlation with relevant clinical parameters. Reliability was evaluated by Cronbach's alpha, the intraclass correlation coefficient, and the Bland-Altman plot. Results: The Thai GO-QOL version showed high CVI (0.97) and a moderate negative correlation of the functional QOL score with disease severity (r = − 0.49), the clinical activity score (r = − 0.31), and exposure parameter (r = − 0.32). It showed good reliability with a high intraclass correlation coefficient (0.92) and high Cronbach' s coefficient (0.86). Conclusion: The Thai GO-QOL has good validity and reliability. It can be used to evaluate the quality of life of Graves' ophthalmopathy patients as a consequence of their disease in thyroid treatment programs.

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“…In a recent study of patients with hyperthyroidism, male sex and the absence of ophthalmopathy were associated with better quality of life. 33…”

Section: Thyroid Eye Diseasementioning

confidence: 99%

Eye Conditions in Women

Wishna

Hurtig

Templeton

2020

Gender and the Genome

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Changes in vision can have significant impact on health and quality of life. Differences between women and men have been identified in the incidence of several eye conditions. Some of these differences are a result of the greater longevity of women. However, the eye, like other organs, is susceptible to the impacts of inflammation and sex steroids. Conditions, such as thyroid eye disease, optic neuritis, and dry eye disease are related to autoimmune or inflammatory conditions and are, thus, more common among women. Idiopathic intracranial hypertension occurs disproportionately in women of childbearing age; the etiology of this condition appears to be related to both inflammatory and sex hormone fluctuations.

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The relationship between quality of life, cognition, and thyroid status in Graves’ disease

Abstract: An impairment in QoL among patients with active GD was evidenced, even in those receiving thionamides and in euthyroidism. Ophthalmopathy was a factor associated with a poor QoL and no clear evidence of cognitive impairment was demonstrated.

Cited by 35 publications

References 30 publications

<p>Reversible Affective Symptoms and Attention Executive Control Network Impairment Following Thyroid Function Normalization in Hyperthyroidism</p>

<p>Reversible Affective Symptoms and Attention Executive Control Network Impairment Following Thyroid Function Normalization in Hyperthyroidism</p>

Development and psychometric properties of the Thai Graves’ ophthalmopathy quality of life (GO-QOL) questionnaire

Eye Conditions in Women

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