Is Peripheral Oxygen Saturation a Reliable Predictor of Upper Airways Air-Flow Limitation?

Mozzillo, Nicola; Laora, Andrea Di; Barbetta, Carlo; Groppo, Elisabetta; Tugnoli, V.; Sette, Elisabetta; Astolfi, Luca; Beswick, William F.; Borin, Michela; Ciorba, Andrea; Pelucchi, Stefano; Stomeo, Francesco; Contoli, Marco

doi:10.1016/j.jemermed.2018.07.007

Cited by 4 publications

(7 citation statements)

References 23 publications

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“…Mild respiratory impairment was induced for approximately 7 min. Recent research has highlighted that moderate breathlessness (modified Borg scale score exceeding 3) affected SpO2 [36] and oxy-haemoglobin concentration [37]. Moreover, the potential implications of moderate-to-severe dyspnoea on blood oxygen level-dependent (BOLD) contrast, a core element of fMRI [38], highlight the significance of understanding its influence.…”

Section: Unique Point Of Our Resistive Loadmentioning

confidence: 99%

“…The modified Borg scale is a 12-point scoring system with ratings ranging from 0 to 10 with verbal anchors that are more convenient for interindividual comparisons and correlate well with physiological parameters during exercise testing [54,55]. The modified Borg scale is widely used to evaluate dyspnoea intensity in healthy and cardiopulmonary populations [36] and acute bronchospasms, such as obstructive pulmonary disease (COPD) and asthma [54]. A strong correlation has been reported between the intensity of breathlessness as described by the modified Borg scale and the amount of work performed during exercise [56,57].…”

Section: Correlation With Clinical Score (Modified Borg Scale)mentioning

confidence: 99%

See 1 more Smart Citation

Altered Functional Connectivity during Mild Transient Respiratory Impairment Induced by a Resistive Load

Yorita,

Kawayama,

Inoue

et al. 2024

Preprint

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Background: Previous neuroimaging studies have identified brain regions related to respiratory motor control and perception. However, little is known about the resting-state functional connectivity (FC) associated with respiratory impairment. We aimed to determine the FC involved in mild respiratory impairment without changing the saturation of percutaneous oxygen. Methods: We obtained resting-state functional magnetic resonance imaging data from 36 healthy volunteers during normal respiration and mild respiratory impairment induced by resistive load (effort breathing). ROI-to-ROI and seed-to-voxel analyses were performed using Statistical Parametric Mapping 12 and the CONN toolbox. Results: Compared to normal respiration, effort breathing activated FCs within and between the sensory perceptive area of respiration (the postcentral gyrus, anterior insular cortex (AInsula), and anterior cingulate cortex) and visual cortex (the visual occipital, occipital pole (OP), and occipital fusiform gyrus). Graph theoretical analysis showed strong centrality in the visual cortex. A significant positive correlation was observed between the dyspnoea score (modified Borg scale) and FC between the left AInsula and right OP. Conclusions: These results suggested that the FCs within the respiratory sensory area via the network hub may be neural mechanisms underlying effort breathing and modified Borg scale scores.

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Section: Unique Point Of Our Resistive Loadmentioning

confidence: 99%

Section: Correlation With Clinical Score (Modified Borg Scale)mentioning

confidence: 99%

Altered Functional Connectivity during Mild Transient Respiratory Impairment Induced by a Resistive Load

Yorita,

Kawayama,

Inoue

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Mild respiratory impairment was induced for approximately 7 min. Recent research has highlighted that moderate breathlessness (modified Borg scale score exceeding 3) affected SpO 2 [37] and oxy-haemoglobin concentration [38]. Furthermore, the potential impact of moderate-to-severe dyspnoea on blood oxygen level-dependent (BOLD) contrast, a core element of fMRI [39], highlights the significance of understanding its influence.…”

Section: Unique Point Of Our Resistive Loadmentioning

confidence: 99%

“…The modified Borg scale is a 12-point scoring system with ratings ranging from 0 to 10 with verbal anchors that are more convenient for comparisons between individuals and correlate well with physiological parameters during exercise testing [58,59]. The modified Borg scale is widely used to assess the intensity of dyspnoea in healthy and cardiopulmonary populations [37] and acute bronchospasms, such as COPD and asthma [58]. It has been reported that there is a strong correlation between the intensity of breathlessness, as described by the modified Borg scale, and the amount of work performed during exercise [60].…”

Section: Correlation With Clinical Score (Modified Borg Scale)mentioning

confidence: 99%

Altered Functional Connectivity during Mild Transient Respiratory Impairment Induced by a Resistive Load

Yorita,

Kawayama,

Inoue

et al. 2024

JCM

View full text Add to dashboard Cite

Background: Previous neuroimaging studies have identified brain regions related to respiratory motor control and perception. However, little is known about the resting-state functional connectivity (FC) associated with respiratory impairment. We aimed to determine the FC involved in mild respiratory impairment without altering transcutaneous oxygen saturation. Methods: We obtained resting-state functional magnetic resonance imaging data from 36 healthy volunteers during normal respiration and mild respiratory impairment induced by resistive load (effort breathing). ROI-to-ROI and seed-to-voxel analyses were performed using Statistical Parametric Mapping 12 and the CONN toolbox. Results: Compared to normal respiration, effort breathing activated FCs within and between the sensory perceptual area (postcentral gyrus, anterior insular cortex (AInsula), and anterior cingulate cortex) and visual cortex (the visual occipital, occipital pole (OP), and occipital fusiform gyrus). Graph theoretical analysis showed strong centrality in the visual cortex. A significant positive correlation was observed between the dyspnoea score (modified Borg scale) and FC between the left AInsula and right OP. Conclusions: These results suggested that the FCs within the respiratory sensory area via the network hub may be neural mechanisms underlying effort breathing and modified Borg scale scores. These findings may provide new insights into the visual networks that contribute to mild respiratory impairments.

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“…For the next critical outcome of time to identification of CPA, 2 clinical trials 185,191 (very low quality of evidence, downgraded for very serious indirectness and serious inconsistency), 6 observational studies [192][193][194][195][196][197] (very low quality of evidence, downgraded for very serious indirectness and serious inconsistency), and 5 experimental studies [198][199][200][201][202] (very low quality of evidence, downgraded for very serious indirectness) were identified that addressed the PICO question.…”

Section: Consensus On Sciencementioning

confidence: 99%

2024 RECOVER Guidelines: Monitoring. Evidence and knowledge gap analysis with treatment recommendations for small animal CPR

Brainard,

Lane,

Burkitt‐Creedon

et al. 2024

J Vet Emergen Crit Care

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ObjectiveTo systematically review evidence on and devise treatment recommendations for patient monitoring before, during, and following CPR in dogs and cats, and to identify critical knowledge gaps.DesignStandardized, systematic evaluation of literature pertinent to peri‐CPR monitoring following Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology. Prioritized questions were each reviewed by Evidence Evaluators, and findings were reconciled by Monitoring Domain Chairs and Reassessment Campaign on Veterinary Resuscitation (RECOVER) Co‐Chairs to arrive at treatment recommendations commensurate to quality of evidence, risk:benefit relationship, and clinical feasibility. This process was implemented using an Evidence Profile Worksheet for each question that included an introduction, consensus on science, treatment recommendations, justification for these recommendations, and important knowledge gaps. A draft of these worksheets was distributed to veterinary professionals for comment for 4 weeks prior to finalization.SettingTransdisciplinary, international collaboration in university, specialty, and emergency practice.ResultsThirteen questions pertaining to hemodynamic, respiratory, and metabolic monitoring practices for identification of cardiopulmonary arrest, quality of CPR, and postcardiac arrest care were examined, and 24 treatment recommendations were formulated. Of these, 5 recommendations pertained to aspects of end‐tidal CO2 (ETco2) measurement. The recommendations were founded predominantly on very low quality of evidence, with some based on expert opinion.ConclusionsThe Monitoring Domain authors continue to support initiation of chest compressions without pulse palpation. We recommend multimodal monitoring of patients at risk of cardiopulmonary arrest, at risk of re‐arrest, or under general anesthesia. This report highlights the utility of ETco2 monitoring to verify correct intubation, identify return of spontaneous circulation, evaluate quality of CPR, and guide basic life support measures. Treatment recommendations further suggest intra‐arrest evaluation of electrolytes (ie, potassium and calcium), as these may inform outcome‐relevant interventions.

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Is Peripheral Oxygen Saturation a Reliable Predictor of Upper Airways Air-Flow Limitation?

Cited by 4 publications

References 23 publications

Altered Functional Connectivity during Mild Transient Respiratory Impairment Induced by a Resistive Load

Altered Functional Connectivity during Mild Transient Respiratory Impairment Induced by a Resistive Load

Altered Functional Connectivity during Mild Transient Respiratory Impairment Induced by a Resistive Load

2024 RECOVER Guidelines: Monitoring. Evidence and knowledge gap analysis with treatment recommendations for small animal CPR

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