The activity of Artemisia spp. and their constituents against Trypanosomiasis

Naß, Janine; Efferth, Thomas

doi:10.1016/j.phymed.2018.06.002

Cited by 57 publications

(27 citation statements)

References 35 publications

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“…They demonstrated high efficiency against a variety of cancer cells, with minor side effects to normal cells in cancer patients [40,41]. The investigation of the biological activity of Artemisia species and their constituents is required to explore the full potential of diverse Artemisia species and their chemical ingredients against cancer, malaria, and infections [42]. Artemisinin can also exert beneficial effects in treatment of the wide-spectrum diseases such as obesity, diabetes, and aging-related disorders [43].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Artemisinin Contents in Selected Artemisia Species from Tajikistan (Central Asia)

et al. 2019

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Background: Central Asia is the center of origin and diversification of the Artemisia genus. The genus Artemisia is known to possess a rich phytochemical diversity. Artemisinin is the shining example of a phytochemical isolated from Artemisia annua, which is widely used in the treatment of malaria. There is great interest in the discovery of alternative sources of artemisinin in other Artemisia species. Methods: The hexane extracts of Artemisia plants were prepared with ultrasound-assisted extraction procedures. Silica gel was used as an adsorbent for the purification of Artemisia annua extract. High-performance liquid chromatography with ultraviolet detection was performed for the quantification of underivatized artemisinin from hexane extracts of plants. Results: Artemisinin was found in seven Artemisia species collected from Tajikistan. Content of artemisinin ranged between 0.07% and 0.45% based on dry mass of Artemisia species samples. Conclusions: The artemisinin contents were observed in seven Artemisia species. A. vachanica was found to be a novel plant source of artemisinin. Purification of A. annua hexane extract using silica gel as adsorbent resulted in enrichment of artemisinin.

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Section: Introductionmentioning

confidence: 99%

Assessment of Artemisinin Contents in Selected Artemisia Species from Tajikistan (Central Asia)

et al. 2019

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“…Indeed, artesunate exerts superior antimalarial effects in clinical application and is characterized by an excellent safety profile [60]. Furthermore, in recent years, several additional activities beyond anti-malarial activity have been observed [22,61]. In this respect, pre-clinical studies on artesunate have demonstrated anti-tumor activity against many different cancers including colon caancer [29], lung adenocarcinoma [31], pancreatic cancer [33], breast cancer [62] and different hematological malignancies [30,32,63].…”

Section: Discussionmentioning

confidence: 99%

Artesunate Affects T Antigen Expression and Survival of Virus-Positive Merkel Cell Carcinoma

Sarma

Willmes

Angerer

et al. 2020

Cancers

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Merkel cell carcinoma (MCC) is a rare and highly aggressive skin cancer with frequent viral etiology. Indeed, in about 80% of cases, there is an association with Merkel cell polyomavirus (MCPyV); the expression of viral T antigens is crucial for growth of virus-positive tumor cells. Since artesunate-a drug used to treat malaria-has been reported to possess additional anti-tumor as well as anti-viral activity, we sought to evaluate pre-clinically the effect of artesunate on MCC. We found that artesunate repressed growth and survival of MCPyV-positive MCC cells in vitro. This effect was accompanied by reduced large T antigen (LT) expression. Notably, however, it was even more efficient than shRNA-mediated downregulation of LT expression. Interestingly, in one MCC cell line (WaGa), T antigen knockdown rendered cells less sensitive to artesunate, while for two other MCC cell lines, we could not substantiate such a relation. Mechanistically, artesunate predominantly induces ferroptosis in MCPyV-positive MCC cells since known ferroptosis-inhibitors like DFO, BAF-A1, Fer-1 and β-mercaptoethanol reduced artesunate-induced death. Finally, application of artesunate in xenotransplanted mice demonstrated that growth of established MCC tumors can be significantly suppressed in vivo. In conclusion, our results revealed a highly anti-proliferative effect of the approved and generally well-tolerated anti-malaria compound artesunate on MCPyV-positive MCC cells, suggesting its potential usage for MCC therapy.Cancers 2020, 12, 919 2 of 15 cells [6], and subsequent studies confirmed that approximately 80% of all MCC cases are associated with MCPyV [7]. Importantly, the integration patterns suggest that clonal expansion of the tumor cells occurs after MCPyV integration sustaining the assumption that viral proteins are causal for tumorigenesis [6,8,9]. Moreover, in MCPyV-positive MCC cells, expression of the viral oncoproteins small and Large T-antigen (sT and LT) can be detected, and these proteins are essential for growth of the tumor cells [10,11] qualifying them as potential therapeutic targets.The five-year overall survival rate for patients with MCC is only about 40%, although the relative survival rate (compared to an age-and sex-matched population) is 54% [12]. Primary MCCs are excised by surgery, and adjuvant radiotherapy of the primary tumor location and the lymph node region is recommended [13]. Until recently, the metastatic disease was treated preferentially with various, not-standardized chemotherapeutic regimens, all of which could not improve survival of the patients significantly [14]. Recently, however, antibodies targeting the immune suppressive protein programmed cell death protein 1 (PD-1) or its ligand PD-L1 have demonstrated high response rates of 56 in first-line and 32% in second-line treatment, respectively for patients with stage IV disease [15,16]. Indeed, the PD-L1 targeting antibody Avelumab was the first treatment for metastatic MCC approved both in the US and European Union [17]. Importantly, data avail...

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“…The genus Artemisia is composed by plants used for different ethnomedicinal practices (Bora and Sharma, 2011; Olennikov et al, 2018) and some Artemisia -derived compounds are promising anti-protozoa agents (Emami et al, 2012). In addition, a recent review showed the application of Artemisia plants and their constituents against Trypanosomiasis (Naß and Efferth, 2018). Since several papers evaluated the leishmanicidal effects of the Artemisia genus, in this section we reviewed studies where in vivo assays were employed along with the identification of the active(s) compound(s).…”

Section: Compounds Isolated From Artemisia Plants Are Active Against mentioning

confidence: 99%

“…and T. cruzi (Sülsen et al, 2008; Beer et al, 2016; García et al, 2017; Kimani et al, 2017; Laurella et al, 2017). Indeed, Asteraceae plants play important ethnopharmacological role worldwide making them attractive candidates for drug development (Ali et al, 2017; Carvalho et al, 2018; Fattori et al, 2018; Naß and Efferth, 2018).…”

Section: Introductionmentioning

confidence: 99%

Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease

et al. 2019

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Leishmaniasis and Chagas disease cause great impact on social and economic aspects of people living in developing countries. The treatments for these diseases are based on the same regimen for over 40 years, thus, there is an urgent need for the development of new drugs. In this scenario, Asteraceae plants (a family widely used in folk medicine worldwide) are emerging as an interesting source for new trypanocidal and leishmanicidal compounds. Herein, we provide a non-exhaustive review about the activity of plant-derived products from Asteraceae with inhibitory action toward Leishmania spp. and T. cruzi . Special attention was given to those studies aiming the isolation (or identification) of the bioactive compounds. Ferulic acid, rosmarinic acid, and ursolic acid ( Baccharis uncinella DC.) were efficient to treat experimental leishmaniasis; while deoxymikanolide ( Mikania micrantha ) and (+)-15-hydroxy-labd-7-en-17-al ( Aristeguietia glutinosa Lam.) showed in vivo anti- T. cruzi action. It is also important to highlight that several plant-derived products (compounds, essential oils) from Artemisia plants have shown high inhibitory potential against Leishmania spp., such as artemisinin and its derivatives. In summary, these compounds may help the development of new effective agents against these neglected diseases.

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The activity of Artemisia spp. and their constituents against Trypanosomiasis

Cited by 57 publications

References 35 publications

Assessment of Artemisinin Contents in Selected Artemisia Species from Tajikistan (Central Asia)

Assessment of Artemisinin Contents in Selected Artemisia Species from Tajikistan (Central Asia)

Artesunate Affects T Antigen Expression and Survival of Virus-Positive Merkel Cell Carcinoma

Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease

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