“…MSCs have the potential to differentiate in vivo and in vitro into myofibroblasts, adipocytes, chondrogenic, and osteogenic cells (Agley et al, 2013; Contreras et al, 2019c; Oishi et al, 2013; Uezumi et al, 2014b; Uezumi et al, 2011; Wosczyna et al, 2012). These PDGFRα + MSCs are found in most tissues, including bone marrow, heart, kidney, muscle, nerves, liver, lung, and skin in which they play crucial roles (Carr et al, 2019; Lemos and Duffield, 2018; Lynch and Watt, 2018; Rognoni et al, 2018). Despite their required normal activity during muscle regeneration (Joe et al, 2010; Heredia et al, 2013; Mathew et al, 2011; Fiore et al, 2016; Wosczyna et al, 2019), we and others have reported dysregulated behavior of these precursor cells in models of acute and chronic muscle damage, muscular dystrophy (MD), neurodegenerative diseases, and aging (Acuña et al, 2014; Contreras et al, 2016; Contreras et al, 2019c; González et al, 2017; Kopinke et al, 2017; Madaro et al, 2018; Mahmoudi et al, 2019; Lemos et al, 2015; Lukjanenko et al, 2019; Uezumi et al, 2014a).…”