Glycolic acid cream for treatment of molluscum contagiosum

Dave, Dharmendra; Abdelmaksoud, Ayman

doi:10.1111/dth.12630

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…There are scarce data in the literature about the use of GA in the treatment of MC. A study conducted by Dave and Abdelmaksoud 7 had treated nine patients (seven males and two females), with Fitzpatrick type III skin type, aged between 3 and 24 years with GA cream at two concentrations: 6% and 12%. On the other hand, in our study, 60 patients were treated with 20% GA applied weekly.…”

Section: Discussionmentioning

confidence: 99%

A randomized control trial of 20% glycolic acid versus 30% salicylic acid in the management of molluscum contagiosum

Nai

Ghiya

Mohta

et al. 2022

J Cutan Aesthet Surg

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Section: Discussionmentioning

confidence: 99%

A randomized control trial of 20% glycolic acid versus 30% salicylic acid in the management of molluscum contagiosum

Nai

Ghiya

Mohta

et al. 2022

J Cutan Aesthet Surg

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“…Molluscum contagiosum (MC) is a common, benign viral skin infection in children, characterized by a dome-shaped, round, and pinkish papula, caused by a Pox virus family. [1][2][3] This skin disease is usually self-limiting, hence awaiting spontaneous resolution should be considered. Current treatment options include physical elimination through curettage or cryotherapy, topical medications with salicylic acid (SAL), lactic acid (LAC), tretinoin, cantharidin, podophyllotoxin, imiquimod, hydrogen peroxide or potassium hydroxide (KOH), and systemic treatment with cimetidine.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Side Effects of Topical Applications of Two Different Solutions in the Treatment of Molluscum Contagiosum in a City in Africa: An Open, Randomized, Comparative Clinical Trial

Öztürk

2019

J Pediatr Infect Dis

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Molluscum contagiosum (MC) is one of the most common viral infections in African children. However, there is no work investigating the treatment of MC in dark skinned children in Africa. In this study, we aimed to compare efficacy and side effects of topical application of 10% potassium hydroxide (KOH) and 16.7% salicylic acid (SAL) and lactic acid (LAC) combination in the treatment of MC in Sudan, Africa. This is a prospective, randomized, and comparative study. The inclusion criterion was the presence of at least 10 lesions. The exclusion criteria were the use of any topical MC treatment during the last 2 weeks, immunosuppression, periorbital and perioral involvement, the history of hypersensitivity to any kind of keratolytics, and the presence of concomitant bacterial skin infections. The main efficacy outcome was the complete remission or partial remission. Three visits were performed: baseline visit (diagnosis, randomization, and therapy initiation), visit 1 for follow-up (at 15–30 days after initiation of therapy and for study end), and visit 2 for postclearing assessment (at 60th day after the initiation of therapy). Chi-squared (χ2) test was used. All patients (n = 101) participating completed the 60 days of follow-up period. Post 60 days of treatment, the rates of complete resolution in 55 patients treated with 10% KOH solution and 47 patients treated with 16.7% SAL + LAC combination solution were 87.0 and 85.1% (p > 0.05), respectively. The rates of partial resolution in the group treated with KOH solution and in patients treated with SAL + LAC combination solution were 12.9% and 14.8% (p > 0.05), respectively. Major side effects in KOH group were burning sensation or stinging during application (48.1%, p = 0.0009) and hypopigmentation (38.8%, p = 0.007) while it was desquamation (23.4%, p > 0.05) in the SAL + LAC combination group. Results indicate both 10% KOH solution and SAL + LAC combination solution showed good efficacy in the treatment of MC in African children. Neither 10% KOH nor the SAL + LAC combination solution was found superior to other in the treatment, while the latter was noted to have fewer side effects. Permanent hypopigmentation is an important and undesired side effect of 10% KOH treatment.

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“…Molluscum Contagiosum is caused by a Pox virus family, affecting mainly children with prevalence in immunocompetent children of approximately 7% and human immunodeficiency virus (HIV) positive adult patients up to 18% [1].…”

Section: Introductionmentioning

confidence: 99%

Efficacy Of 10% Potassium Hydroxide Solution Versus 10% Salicylic Acid Ointment in Treatment of Molluscum Contagiosum - the Low - Cost Dermatologic Therapy in Vietnam

Huu¹,

Quang²,

Van³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND:Molluscum contagiosum is a common viral disease primarily affecting children.AIM:The objective is to compare the efficacy of 10% potassium hydroxide (KOH) solution versus 10% salicylic pomade in the treatment of molluscum contagiosum.METHODS:Clinical trials on 70 patients were randomised into 2 groups: 39 patients treated with 10% KOH solution and 31 patients treated with 10% salicylic pomade. The evaluation was based on the complete clearance of lesions, side effects and complications of the drug.RESULTS:The clearance of all lesions after 2, 4, 6, 8 weeks of treatment in both groups were 7.7%; 23.1%; 53.8%; 79.5% and 0%; 3.2%, 9.7% 22.6%, respectively (p < 0.05). Side effects were seen in both groups include burning (76.9% versus 19.4%; p < 0.05); redness (59% versus 14%; p < 0.01); desquamation (12.8% versus 19.3%; p < 0.05).CONCLUSION:The efficacy of KOH solution in the treatment of MC was better than that of salicylic pomade and both products are safe, effective, and easy to apply at home.

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Glycolic acid cream for treatment of molluscum contagiosum

Cited by 5 publications

References 4 publications

A randomized control trial of 20% glycolic acid versus 30% salicylic acid in the management of molluscum contagiosum

A randomized control trial of 20% glycolic acid versus 30% salicylic acid in the management of molluscum contagiosum

Efficacy and Side Effects of Topical Applications of Two Different Solutions in the Treatment of Molluscum Contagiosum in a City in Africa: An Open, Randomized, Comparative Clinical Trial

Efficacy Of 10% Potassium Hydroxide Solution Versus 10% Salicylic Acid Ointment in Treatment of Molluscum Contagiosum - the Low - Cost Dermatologic Therapy in Vietnam

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